Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis.

Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite.

Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria.

Dickson, Daniel and Vincent solve the case of the Female with Itchy Anus, and reveal the structure of a roundworm membrane protein involved in digestion of nutrients.

Dickson, Daniel and Vincent solve the case of the Ugandan Volunteer With Morning Bites and discuss integration of HIV-1 into the Schistosome genome, with a sprinkling of COVID-19 throughout.

Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs.

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin.

The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia.

The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice.

The TWiPpers of the bite fantastic solve the case of the Indian Man Who Hiked, and discuss the effects of schistosome soluble egg antigen on infection of lymphocytes with HIV-1.

The TWiP’ers solve the case of the Sudanese Boy With Fever, and reveal antibodies that slow invasion of red blood cells potentiate other malaria-blocking antibodies

The TWiPloid organisms solve the case of the Doctor with Chronic Epigastric Pain, and reveal how levels of linoleic acid in the intestine enable the sexual cycle of Toxoplasma gondii in cats.

The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species.

The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus.

The TWiPlicates solve the case of the Child With Retinal Granuloma, and discuss an association of the complement protein collectin-11 with the pathophysiology of Chagas disease.

The Podfessors solve the case of the Teenager With Swollen Scrotum, and continue the story arc of Daniel’s favorite cells, B-1 cells, and their association with protective immune responses in human Chagas disease.

The TWiP team solve the case of the Four Year Old with Fever, Headache, and Cough, and discuss the release of extracellular vesicles from Leishmania amazonensis that manipulate the host immune response.

The TWiP legends solve the case of Surfer Sans Septum, and discuss how two symbiotic bacteria in the tsetse fly might allow colonization with Trypanosoma brucei.

The doctors of awesome solve the case of the Woman Who Visited Lebanon, and reveal that immunoglobulins protect the olfactory organ of trout against infection with the Ich parasite.

The TWiP professors solve the case of the Baby With Pericardial Effusion, and discuss whether the flagellate without a flagella, Dientamoeba fragilis, causes human illness.

The TWiPsters solve the case of the Brazilian Immigrant With Heart Problems, and describe how genome organization controls trypanosome antigenic variation.

The TWiPlets solve the case of the Electrician from Tamil Nadu with a Liver Mass, and reveal that dogs and humans share a common Chadian Guinea worm.

The TWiP triptych solve the case of the 9/11 Survivor infested with parasites, and discuss the effect of community ivermectin treatment for onchocerciasis on Loa loa infections.

The TWiP hosts solve the case of the Thai Woman With Red Bumps, and reveal that a master manipulator contacts ant brain tissue to control its behavior.

Justin joins the TWiP team to solve the case of the Gentleman with B cell Lymphoma, and consider the finding of Dracunculus species in river otters from Arkansas.

Vincent and Daniel solve the case of the Man in the City with Groin Rash, catch up on the long backlog of email, and present a new case, possibly the most complex one yet on the show.

Vincent and Daniel solve the case of the Panamanian Farmer with Three Weeks of Diarrhea, and discuss how microbes egested during bites of sand flies exacerbate the severity of leishmaniasis.

The TWiP peeps solve the case of the Panamanian Mother with Steatorrhea, and reveal new monoclonal antibodies that effectively block malarial infection.

The TWiPers solve the case of the Panamanian Man With Leg Ulcer, and describe how a crab predator preferentially feeds on parasite infected prey – even though the parasite makes them faster!

Shivang joins the TWiP triumvirate to solve the case of the New Yorker With Rash and Pins and Needles, and reveal how agrochemicals increase risk of human schistosomiasis by causing high snail density.

The TWiP-tologists solve the case of the Child in South America With Belly Pain, and reveal how B1 cell IgE blocks parasite clearance by inhibiting mast cell activation by B2 cell IgE.

The TWIPniks solve the case of the Man With Diarrhea and 100 Micron Objects In Stool, and discuss the reticulocyte receptor for Plasmodium vivax.

The Estimados Profesores of TWIP solve the case of the Man With Motile Objects, and reveal the secreted and excreted proteins of Giardia parasites.

The TWiPtomaniacs solve the case of the Boy With Visual Disturbances and Itching, and discuss identifying secreted and excreted proteins of Trichinella parasites.

The TWiPians solve the case of the Woman With Anemia, Eosinophila, and a Worm in Her Intestine, and discuss a study on the function and druggability of two malarial aspartate proteases.

The TWiPsids solve the case of the Guatemalan Positive for Rhinovirus, and reveal how to kill all African trypanosomes with a primate apolipoprotein.

The TWiP Wataalamu solve the case of the One Year Old From Kenya With Moving  Skin Lesions, and describe how to make mosquitoes refractory to Plasmodium with engineered symbiotic bacteria.

The triple TWiP solve the case of the Peace Corp Veteran with Eosinophilia, and discuss the genome sequence of the hyper-prevalent parasitic eukaryote Blastocystis.

The TWiPwalas solve the case of the Woman with a Worm in Her Eye, and discuss the role of nitric oxide in the resistance of rats to Schistosoma japonicum.

The TWiPtoids solve the case of the Man from India with a Neck Lump, and explore the role of a transmissible dysbiotic skin microbiome in inflammation during cutaneous leishmaniasis.

The TWiP Titans solve the case of the Man from Queens with a Blister Burster, and explain the role of inflammatory monocytes during Leishmania infection of the skin.

Dickson returns to the TWiP hosts to solve the case of the Woman from Colorado With Loose Stools, and explain how single-sex infection with female Schistosoma mansoni reduces hepatic fibrosis.

Daniel and Vincent solve the case of the Haitian Girl Who Failed To Thrive, and visit two studies that address the question of whether infection with Toxoplasma gondii alters human behavior.

Daniel and Vincent solve the case of the Woman With Anal Area Discomfort, and discuss the multiple functions of a clathrin adapter protein in formation of rhoptry and microneme secretory organelles of Toxoplasma gondii.

The TWiP-tastic peeps solve the case of the Thai Man Coughing Up Blood, and reveal potential therapies for trypanosomiasis that are inhibitors of protein import into glycosomes.

Jonathan from the podcast Arthro-Pod joins the TWiPerati to solve the case of the Peruvian Woman With Inguinal Insect Bite, and discuss warm autoimmune hemolytic anemic that develops after babesiosis.

The TWiPniks solve the case of the Man With AIDS, and explore how secretion of extracellular vesicles influences the social motility of Trypanosoma brucei.

The TWiP Masters solve the case of the Australian Wildlife Carer, and review evidence that nodding syndrome may be caused by an autoimmune reaction to the parasitic worm that causes river blindness.

The TWiPerati solve the case of the Man Who Sat in Feces, and discuss a study on how Dickson’s favorite parasite induces the formation of a collagen capsule.

The TWiPsters solve the case of the Peace Corps Volunteer with a Liver Lesion, and discuss the dependence of Leishmania survival on the gut microbiome of the sandfly.

The TWiP Trinity solve the case of the Peace Corps volunteer with diarrhea, and reveal how immunizing against a virus ameliorates exacerbated leishmaniasis.

The TWiPonderers solve the case of the Timber Worker with Severe Shaking Chills, and describe an experimental malaria vaccine comprising attenuated sporozoites produced by genetic engineering.

The prolific podcast-shedding Hosts solve the case of the Global Health Intern with a snakelike lesion on her foot, and reveal the role of a single-stranded DNA binding protein in differentiation of trypanosomes.

The TWiPanorama solve the case of the Dutch Woman with Wormy Objects in Her Stool, dissect a study on cytoadhesion of malaria infected red blood cells, and introduce Parasitology Superheroes.

The TWiPanosome docs solve the case of the Mali Man with Profuse Diarrhea, and review the presence of Trypanosoma cruzi in vectors, canids, and humans along the Texas-Mexico border.

The TWiP triumvirate solve the case of the Thai Woman with Facial Swelling, and explain how Th17 T cells protect against the intracellular parasite Trypanosoma cruzi.

Vincent and Daniel solve the case of the Family with Eosinophilia, and discuss HIV-1 infection and genome integration in the blood fluke Schistosoma mansoni.

The parasite prophets solve the case of the Thai Man with Abdominal Distention, and discuss the finding that metastatic leishmaniasis dependent on a virus can be prevented by blocking IL-17A.

The TWiPtoids solve the case of the Thai Fisherman with Chronic Diarrhea, and reveal a potential new drug for treatment of leishmaniasis, Chagas diseases, and sleeping sickness.

The TWiPlets solve the sad case of the Boy Who Went Swimming, and explain why the tomato is resistant to the plant parasite Cuscuta.

The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella.

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn’s disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.

The TWiP trio solve the case of the bug bites all in a row, and talk about a secreted Toxoplasma protein that is central to the parasite’s manipulation of host cells.

The TWiP trio visit the Bronx Zoo where Paul solves the case of the Four Year Old with Pulmonary Edema, and talks about his career as the Chief Veterinarian and Director of the Zoological Health program for the Wildlife Conservation Society.

Daniel and Vincent solve the case of the Truck Driver from India, discuss why parasites resistant to an antimalarial drug are not transmitted by mosquitoes, and introduce Paul who presents a new case study.

The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity.

Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, and discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis.

The TWiP-scholars solve the case of the Housewife from Kolkata, discuss mutations in the IL17 gene associated with cerebral malaria, and hear a case presentation from guest Michael Libman.

The TWiPyzoites solve the case of the Uncommon Parasite, and discuss the role of eosinophils in promoting the growth of Trichinella in skeletal muscle.

The doctors TWiP solve the case of the Woman with White Worms, and explain the role of a secreted growth factor from a carcinogenic parasite in wound healing and angiogenesis.

The TWiP trifecta solves the case of the Woman from Bolivia with Belly Pain, and discuss a method for population modification of malaria mosquitoes using a Cas9-mediated driver gene.

The TWiP-lets reveal Balamuthia infection in the Children from Peru, and discuss resistance to pyrethroids uncovered by RNA sequencing of Anopheles mosquitoes.

The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium.

The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis.

Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for Leishmania infections.

Vincent, Dickson, and Daniel solve the case about the man from El Salvador, and discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis.

Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption.

Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study.

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study.

Vincent, Dickson, and Daniel reveal last week’s case study and introduce a new one concerning a patient who traveled to Belize.

Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene.

Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and present another mystery for your solving.

Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study.

Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study.

Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation.

Vincent, Dickson, and Daniel solve last week’s case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice.

Vincent, Dickson, and Daniel provide the solution to last week’s case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo.

Vincent and Dickson welcome new TWiP host Daniel Griffin to discuss the association of a new Mycoplasma with trichomoniasis, and to introduce a new feature to the show, a case study.

Vincent and Dickson discuss how malaria parasites induce odors in their rodent hosts that attract mosquitoes.

Vincent and Dickson discuss the exchange of messenger RNAs between a parasitic plant and its hosts.

Vincent and Dickson discuss how nibbling of human cells by Entamoeba histolytica, a process called amoebic trogocytosis, contributes to cell killing and tissue invasion.

Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive.

Vincent and Dickson review the finding that urocanic acid in the skin is a chemoattractant for the parasitic nematode Strongyloides stercoralis.

Vincent and Dickson discuss an increase in the altitude of malaria distribution in warmer years in the highlands of Colombia and Ethiopia.

Vincent and Dickson discuss the high diversity of malaria parasites in West African bats, and a vaccine against hookworm.

Vincent and Dickson discuss how infection with Toxoplasma gondii causes mice to lose their aversion to cat urine, even after the parasites have been cleared.

Vincent and Dickson update the multistate outbreak of cyclosporiasis, discuss the avian malaria parasite P. lophurae, and review protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.

Vincent and Dickson discuss Myxobolus cerebralis, the parasite that causes whirling disease of salmonids

Vincent and Dickson consider a case history of a young man with Blastocystis hominis – is it causing his disease?

Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters.

Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in Plasmodium falciparum using zinc finger nucleases.

Vincent and Dickson answer listener emails about Leishmania, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more.

Vincent and Dickson tackle the backlog of listener email, then consider the life cycle and pathogenesis of Trichomonas vaginalis, the flagellated protozoan transmitted by sexual contact.

Vincent and Dickson discuss the life cycle and pathogenesis of Dracunculus medinensis, the filarial nematode that causes dracunculiasis, or Guinea worm disease.

Vincent and Dickson review an in silico pipeline for identifying molecular mimicry candidate proteins in the genomes of parasites, and catch up on listener email.

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson have a broad-ranging conversation with Charles Knirsch of Pfizer, Inc. about how public-private partnerships can function to control and eliminate infectious diseases. Download TWiP #30 (61 MB .mp3,…

Vincent and Dickson continue their discussion of trematodes, or flukes, which have a snail as a reservoir host.

Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.

Vincent and Dickson review Wuchereria bancrofti, the nematode that causes lymphatic filariasis, also known as elephantiasis.

Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necator americanus.

Vincent and Dickson discuss the intracellular parasite Cryptosporidium, which causes diarrheal disease in most mammalian species.

Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histolytica.

Vincent and Dickson review the life cycle and pathogenesis of the flagellated protozoan parasite Giardia lamblia.

Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite Leishmania.

Vincent and Dickson continue their discussion of the obligate intracellular protozoan Toxoplasma gondii with a consideration of the clinical consequences of infection and pathogenesis.

Vincent and Dickson introduce the obligate intracellular protozoan Toxoplasma gondii, one of the most successful parasites on earth.

Vincent and Dickson move on to protozoan parasites with a discussion of the early history of malaria.

Vincent and Dick discuss the nurse cell, a unique structure formed in the host muscle by Trichinella species.

Vincent and Dick distinguish among intracellular and extracellular parasites, then discuss the history and general characteristics of Trichinella spiralis.

Vincent and Dick classify parasites according to whether or not they are transmitted by a vector, then consider the implications of long-lived parasites.