Vincent, Dickson, and Daniel solve the case about the man from El Salvador, and discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis.
Download TWiP #94 (74 MB .mp3, 102 minutes).
Links for this episode:
- Targeting filarial tyrosine kinases (J Inf Dis)
- Onchocerciasis on TWiP 24
- Filariasis on TWiP TWiP 25
- Image shows c-abl kinase bound to imatinib (red)
- Image credit
- What good are ticks?
- Letters read on TWiP 94
Case study for TWiP 94
Daniel’s patient was seen in the clinic. He is a 33 yo chinese male, from Chinatown NYC, for several months on and off has had watery diarrhea, headaches. Tried reflexology, chiropractic therapy, with no results. Has traveled quite a bit, been in Chile (was there a few months before). Came to US when young. Grew up in the US. In Chile, has had many sexual partners, >50, of both sexes, also has done many drugs. Two years ago was diagnosed with chronic HIV, CD4 count 685, on ARVs triple therapy, virus loads are well controlled. Has had syphilis, nose job, no medication allergies. Lives with family. On exam, afebrile, looks well. Symptom onset a few months after last Chile visit. Is an adventurous eater.
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