Immune - Part 5

Immune

Immune 10: Immune goes viral

July 21, 2018
Tagged as: antibodies, antibody escape mutants, broadly neutralizing antibodies, HIV-1, immune, immunology, Rebecca Lynch

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Rebecca Lynch

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 9: Neither mice nor lamprey lie

June 20, 2018
Tagged as: antibodies, hagfish, immune, immunity, immunoglobulins, jawed vertebrates, jawless vertebrates, lamprey, leucine rich repeat, variable lymphocyte receptor, VLR

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Lamprey VLR response to influenza virus (eLife) 34:14
VLR-based immunity (Ann Rev Immunol)
How the Immune System Works 1:13:11
A Commotion in the Blood 1:13:35
Immune merchandise 1:05:34
Image credit 34:53
Letters read on Immune 9 51:27

Weekly Science Picks 1:20:05

Steph – Jon Yewdell on TWiV (208, 467)
Cindy – No polio in Venezuela
Vincent – Is gaming addiction a thing?

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Uncategorized

Immune 8: Staying warm with γδ T cells

May 25, 2018
Tagged as: homeostasis, IL-17A, immune, immunology, T cells, thermogenesis, γδT cells

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) 5:40
γδ17 T cells cells at epithelial barriers (Nat Rev Immunol) 23:35
Image credit
Letters read on Immune 8 59:14

Weekly Science Picks 1:10:45

Steph – Polycystic ovary syndrome and anti-Mullerian hormone
Cindy – Foldscope (Ted talk)
Vincent – Virology Lectures 2018

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 7: Contradictory complements in Alzheimer’s Disease

April 18, 2018
Tagged as: AD, Alzheimer's disease, C1q, complement, immune, immunology, MAC, mouse model, synapse, synaptic pruning

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer’s disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Complement and microglia cause synapse loss in Alzheimer’s (Science) 28:42
Superresolution structured illumination microscopy 48:31, 1:07:33
Image credit

Weekly Science Picks 1:06:50

Steph – Social Media for Social Change in Science and Structured Illumination Microscopy video
Cindy – 314 Action
Vincent – Making American great again requires acting on scientific knowledge

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 6: Potent antiviral antibodies without somatic mutation

March 16, 2018
Tagged as: antibody, B cell, epitope, F protein, IgG, IgM, immune, immune response, immunology, lymph node, respiratory syncytial virus, somatic hypermutation, V(D)J recombination, vaccine enhanced disease

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Potent anti-RSV antibodies without somatic hypermutation (Immunity) 3:38, 33:43
History of vaccine enhanced RSV disease (Clin Vacc Immunol) 9:41
Image credit
Letters read on Immune #6 61:45

Weekly Science Picks 78:56

Steph – REACTOME project (free icons)
Cindy – Gender Imbalance in Stories
Vincent – Trump, Tell Us About Your Flu Shot

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 5: Mother knows best about food allergies

February 22, 2018
Tagged as: allergic reactions, atopy, breast milk, food allergy, immune, immunology, mucosal defenses, mucosal immunology, tolerance

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Food Allergy (Nat Rev Dis Prim) 34:04
Maternal allergen sensitization (J Exp Med) 51:54
Image credit
Letters read on Immune #5 76:08

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 4: Putting the immunotherapy CAR T before the cancer

January 23, 2018
Tagged as: B cell, cancer immunotherapy, CAR T cell, checkpoint inhibitor, chimeric antigen receptor, CTLA4, immune, immunology, immunotherapy, oncology, PD-1, T cell, Tisagenlecleucel

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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- Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) 17:27
- Engineering immune cells to treat cancer (Cell) 44:05
- Engineering T cells for fungal infections (PNAS) 50:16
- CAR T cells for AIDS (PLoS Path) 51:10
- CAR T cells (NIH) 20:04, 29:46
- Transcript of this episode (html, pdf)
- Image credit

Letters read on Immune #4 1:05:59

Weekly Science Picks 1:15:15

Cindy – What’s In A Name?
Steph – Novel Targets
Vincent – Friendly Penguin

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree

December 16, 2017
Tagged as: ADE, antibody dependent enhancement, antibody therapy, bispecific antibody, dengue virus, dengvaxia, immune, immunology, monoclonal antibody, passive vaccine, Zika virus

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Model for dengue ADE (Scitable) 5:40
Dengue ADE in humans (Science) 11:56
Dengvaxia discussion (TWiV 471) 4:28
Bi-specific antibody to Zika virus (Cell) 28:23
Building Zika Virus
Transcript of this episode (html, pdf)
Letters read on Immune #3 58:09

Weekly Science Picks 71:52

Cindy – Questions answered about starving polar bear video
Steph – Deep Work by Cal Newport and Grad Student Tax
Vincent – Making art with Excel

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 2: Lymphocytes after dark

November 25, 2017
Tagged as: 24 hour clock, adaptive immunity, B cell, circadian, clock gene, immune, immunology, lymph, lymph node, lymphocyte, T cell

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph is circadian – it is dependent on the time of day.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Circadian clocks control lymphocyte trafficking (Immunity) 9:50
Lymph node image credit
Letters read on Immune #2 47:16

Weekly Science Picks 68:08

Cindy – Men ask more questions than women at a scientific conference (PLoS One)
Steph – House just voted to bankrupt graduate students
Vincent – Trump’s Legacy: Damaged Brains

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 1: Some like it hot

November 1, 2017
Tagged as: atherosclerosis, bone marrow, fever, immune, immunology, macrophage, monocytes, thermogenesis, thermoregulation, UPC1

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Leifer Lab at Cornell 00:28, 1:31
Stephanie Langel 00:51, 9:28
Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) 25:43
Fever regulates immunity (Nat Rev Immunol)
Transcript of this episode (pdf, html)
Macrophage image by Blausen Medical

Weekly Science Picks 51:13

Cindy – FDA approves second CAR T cell therapy
Steph – Gammaherpesvirus protects against asthma
Vincent – Truth Wins by Jonathan Yewdell

Music by Steve Neal. Immune logo image by Blausen Medical.

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