Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.
Immune 27: Trained immunity
- January 11, 2020
- Tagged as: enhancer, H3K4Me1, immune, immune memory, immunology, innate immunity, LPS, methylation, NK cells, sepsis
Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.