Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight.
Immune 71: Can parasitic worms prevent pandemics?
- September 8, 2023
- Tagged as: coronavirus, COVID-19, helminth, immune, immunology, macrophage, pandemic, roundworm, SARS-CoV-2, T cell
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.
Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler
- February 13, 2021
- Tagged as: antibody, B cells, coronavirus, COVID-19, immune, immunology, memory B cells, pandemic, SARS-CoV-2
Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2.
Immune 40: COVID-19 nuances
- December 30, 2020
- Tagged as: antibody, coronavirus, COVID-19, immune, immunity, immunology, pandemic, SARS-CoV-2, T cell, T cell exhaustion, vaccine
Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.
Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more.
Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.
Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection.
Immune 34: Coronavirus cross-reacting T cells
- August 25, 2020
- Tagged as: CD4 T cell, coronavirus, COVID-19, epitope, MHC molecule, pandemic, peptide, SARS-CoV-2, T cell, T cell epitope, T cell receptor, viral, virology, virus, viruses
Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.
