Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.
Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight.
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.
Immune 46: Bats don’t STING like a bee
- July 27, 2021
- Tagged as: bat, cGAS, DNA sensing, immune, immunology, interferon, STING, virus reservoir, zoonosis
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.
Immune 13: Do no harm
- October 20, 2018
- Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor
The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.
