immunity | Immune

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker…

Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello, Cindy Leifer,…

Immune

Immune 84: Gender-affirming therapy and immune responses with Petter Brodin

September 24, 2024
Tagged as: gender-affirming testosterone treatment, immune responses, immunity, immunology, Keywords: immune, sex hormones, testosterone, transgender, type 1 interferon

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men). Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Guest: Petter Brodin…

Immune

Immune 83: Immune cells eating other cells

August 27, 2024
Tagged as: anaphylaxis, brain development, histamine, IgE, immune, immunity, immunology, interferon, intravital imaging, mast cell, microglia, neuron, neutrophil, neutrophil migration

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.

Immune

Immune 82: Bat antibodies are hot

July 30, 2024
Tagged as: antibody, antibody repertoire, bat, coronavirus, COVID-19, human challenge, immune, immunity, immunology, interferon, pandemic, SARS-CoV-2, temperature sensitive

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight.

Immune

Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes

May 28, 2024
Tagged as: broad spectrum antiviral, immune, immunity, immunology, infant microbiome, maternal diet, neomycin, sexual dimorphism, skin immunity

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health.

Immune

Immune 79: Spa therapy for the immune system

May 26, 2024
Tagged as: hematopoietic stem cells, immune, immunity, immunology, immunosenescence, myeloid cells

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline.

Immune

Immune 78: Tolerance and tolerating many vaccines

March 26, 2024
Tagged as: COVID vaccine, immune, immunity, immunology, infection challenge, microbiome, serotonin, synthetic glycosylated antigens, tolerance

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge.

Immune

Immune 40: COVID-19 nuances

December 30, 2020
Tagged as: antibody, coronavirus, COVID-19, immune, immunity, immunology, pandemic, SARS-CoV-2, T cell, T cell exhaustion, vaccine

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.

Immune

Immune 9: Neither mice nor lamprey lie

June 20, 2018
Tagged as: antibodies, hagfish, immune, immunity, immunoglobulins, jawed vertebrates, jawless vertebrates, lamprey, leucine rich repeat, variable lymphocyte receptor, VLR

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Tag: immunity

Immune 87: When the immune system misbehaves

Immune 86: Where did the SARS-CoV-2 antibodies go?

Immune 84: Gender-affirming therapy and immune responses with Petter Brodin

Immune 83: Immune cells eating other cells

Immune 82: Bat antibodies are hot

Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes

Immune 79: Spa therapy for the immune system

Immune 78: Tolerance and tolerating many vaccines

Immune 40: COVID-19 nuances

Immune 9: Neither mice nor lamprey lie

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