Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.
Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Click arrow to playDownload Immune 63 (62 MB .mp3, 103 min)Subscribe (free): Apple Podcasts, Google Podcasts. RSS, emailBecome…
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Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.
Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.