From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.
Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.
Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.
Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.
Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology.
Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.
