ImmuneImmuneImmuneImmune

Tag: somatic hypermutation

  • Immune

Immune 52: B cell boot camp with Gabriel Victora

  • January 29, 2022
  • Tagged as: antibodies, B cells, germinal center, immune, immunology, lymph node, lymphoid organ, somatic hypermutation

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

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  • Immune

Immune 36: Aberrant immunity in COVID-19

  • October 21, 2020
  • Tagged as: antibody, coronavirus, COVID-19, germinal center, herd immunity, humoral immunity, immune, immune memory, immunology, pandemic, SARS-CoV-2, somatic hypermutation

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

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  • Immune

Immune 6: Potent antiviral antibodies without somatic mutation

  • March 16, 2018
  • Tagged as: antibody, B cell, epitope, F protein, IgG, IgM, immune, immune response, immunology, lymph node, respiratory syncytial virus, somatic hypermutation, V(D)J recombination, vaccine enhanced disease

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

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