Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.
Immune 50: Red blood cells are immune sentinels
- November 11, 2021
- Tagged as: anemia, COVID-19, DNA, immune, immunology, innate immunity, macrophage, red blood cell, sepsis, Tlr9
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.
Immune 27: Trained immunity
- January 11, 2020
- Tagged as: enhancer, H3K4Me1, immune, immune memory, immunology, innate immunity, LPS, methylation, NK cells, sepsis
Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.
Immune 13: Do no harm
- October 20, 2018
- Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor
The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.