Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.
Hosts: Nels Elde and Vincent Racaniello
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- CoV proofreading enzyme stimulates recombination (bioRxiv) 7:38
- CoV spike mutation pipeline (bioRxiv) 41:26
- Issues with CoV sequencing data (virological.org) 57:20
- Bill Hanage on selection vs bottleneck (threader.app) 1:00:24
- Image credit
- Time stamps by Jolene. Thanks!
Science Picks 1:07:44
Nels – In Memoriam: Gordon Lark
Vincent – John Oliver Discussion of Antibody Tests
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Thanks Nels and Vincent..you’re vigilance on nomenclature is appreciated..its uber important..great podcast gentlemen..
Good points! Also, it’s important to remember that rate of transmission of this virus may be more to do with the host population that a particular virus isolate ends up in, rather than due to a SNP. A virus isolate that gets into a few “senior residences” may appear to transmit much more than in other populations.