TWiV 978: Clinical update with Dr. Daniel Griffin
TWiV 978: Clinical update with Dr. Daniel GriffinJanuary 28, 2023In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Click arrow to playDownload TWiV 978 (24 MB .mp3, 39 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) 1:35 Preprint review should form part of PhD programmes and postdoc training (Nature) 3:16 Early and increased Influenza activity among children (CDC) 4:27 COVID-19 vaccines versus pediatric hospitalization (Cell) 8:10 SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) 10:31 Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) 12:47 Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) 14:21 Effects of Dexamethasone use among patients with COVID-19 (IJID) 24:42 Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ) 26:04 Contribute to our MicrobeTV fundraiser at PWB 28:52 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 978 29:25 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
Infectious Disease Puscast #20
Infectious Disease Puscast #20January 25, 2023On episode #20 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/4/23 – 1/17/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 020 (17 MB .mp3, 29 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Neuroinvasive West Nile infection in solid organ transplant recipients (TID) Clinical markers of post-Chikungunya chronic inflammatory joint disease (PLOSNTD) Cholera outbreak in Haiti (CDC) Legionella bononiensis isolated from a hotel water in Nothern Italy (MS) Contemporary pharmacotherapies for nontuberculosis mycobacterial infections (IDT) Defining the optimal duration of therapy for hospitalized patients with UTIs and Bacteremia (CID) Fidaxomicin to prevent recurrent Clostridioides difficile (JAC) Evaluating predictive value of resected proximal bone margins in Diabetic Foot Osteomyelitis(OFID) Postoperative inflammation and fever after elective aortic valve and aortic root replacement (OFID) Fungal nomenclature: managing change is the name of the game (OFID) Clinical microbiology laboratories should use nomenclature based on current taxonomy (JCM) Race and ethnicity: risk factors for fungal infections (PLOS) Mosquito net use in early childhood and survival to adulthood in Tanzania (NEJM) Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand (The Lancet) Music is by Ronald Jenkees [...] Read more...
Immune 64: A tangled web of wires
Immune 64: A tangled web of wiresJanuary 23, 2023Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Click arrow to playDownload Immune 64 (66 MB .mp3, 110 min)Subscribe (free): Apple Podcasts, Google Podcasts. RSS, emailBecome a patron of Immune! Links for this episode MicrobeTV Discord Server Tangled web of wires (Nature) 2:07 Path to group A Streptococcus vaccines (Clin Inf Dis) 18:39 Immune end-types predictive of vaccine responses (Nat Immunol) 25:12 IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol) 35:14 Very bad B cells (Immunity) 44:11 Two epitope Streptococcus monoclonal (EMBO Mol Med) 59:33 Predictor of vaccine-induced antibody responses (Nat Immunol) 1:08:44 Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med) 1:18:25 Neutrophilic inflammation and RSV infection (Science) 1:23:24 Commensals avoiding recognition (Sci Immunol) 1:30:17 Continuous germinal center invasion and immune response diversity (Cell) 1:35:22 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen MedicalSend your immunology questions and comments to immune@microbe.tv [...] Read more...
TWiV 976: Clinical update with Dr. Daniel Griffin
TWiV 976: Clinical update with Dr. Daniel GriffinJanuary 21, 2023In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. Click arrow to playDownload TWiV 976 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China records almost 60,000 COVID-related deaths (SCMP) 6:05 Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature) 9:46 Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA) 15:18 Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID) 19:51 Long COVID outcomes at one year after mild infection (BMJ) 24:38 Major findings, mechanisms and recommendations for Long COVID (Nature) 25:30 Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI) 27:36 Effect of using a structured pacing protocol (JMV) 30:00 Contribute to our MicrobeTV fundraiser at PWB 33:07 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 976 33:30 Don’t crush Paxlovid (pdf) 33:38 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiV 974: Clinical update with Dr. Daniel Griffin
TWiV 974: Clinical update with Dr. Daniel GriffinJanuary 14, 2023In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection. Click arrow to playDownload TWiV 974 (28 MB .mp3, 47 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 more widespread in animals than thought (Nat Geo) 12:34 Increasing ventilation reduces airborne transmission in schools (Frontiers) 14:31 Carbon dioxide monitoring to assess ventilation at a NID conference (CID) 15:58 Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet) 18:39 Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet) 23:49 Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ) 29:29 Contribute to our MicrobeTV fundraiser at PWB 35:28 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 974 36:31 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
Infectious Disease Puscast #19
Infectious Disease Puscast #19January 10, 2023On episode #19 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/22/22 – 1/3/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 019 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Burden of postinfectious symptoms after Acute Dengue (EID) Maribavir for CMV treatment in the real world (OFID) 24-Week all-oral regimen for Rifampin-Resistant Tuberculosis (NEJM) Beta lactam allergy association with surgical site infections (JPIDS) Effect of Macrolides on mortality in Bacteremic Pneumonia (CID) Association of repeated blood cultures with mortality in adult patients with Gram-Negative Bacilli Bacteremia (OFID) Evaluating predictive value of surgical resected proximal bone margins in Diabetic foot Osteomyelitis with clinical outcomes (OFID) Burden of serious Fungal Infections in India (OFID) Bartonella quintana transmitted by head lice (CID) Balamuthia mandrillaris Granulomatous Amoebic Encephalitis (JPIDS) Detecting Leishmania in dogs (PLOS NTD) Primer on home infusion administration methods (OFID) Biomarkers of infection or sepsis at the bedside (ICM) Implementation roadmap for establishing remote infectious disease specialist support in resource-limited settings (OFID) Perceptions and reality of antimicrobial prescribing during the transition to comfort measures (OFID) Can the future of ID escape the inertial dogma of its past? (OFID Music is by Ronald Jenkees [...] Read more...
TWiV 972: Clinical update with Dr. Daniel Griffin
TWiV 972: Clinical update with Dr. Daniel GriffinJanuary 7, 2023In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Click arrow to playDownload TWiV 972 (31 MB .mp3, 52 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) 3:07 Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) 6:56 Antibody evasion properties of BQ and XBB subvariants (Cell) 11:25 Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) 18:02 Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) 19:46 Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) 21:18 Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) 24:34 SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) 29:41 Long-term cardiovascular outcomes of COVID-19 (Nature) 33:40 Heart-disease risk soars after COVID (Nature) 34:31 Contribute to our MicrobeTV fundraiser at PWB 35:20 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 972 36:12 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiV 971: Another year is viral
TWiV 971: Another year is viralJanuary 1, 2023In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 971 (57 MB .mp3, 95 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Our favorite 2022 virology stories:•Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) 20:20•Dickson: Interviews with Paul Offit and Andy Slavitt 27:46•Rich: TWiV 948: Breathless with David Quammen 31:39•Kathy: TWiV 915: Mouse mouth to mouse mom 33:52, 1:00:10•Brianne: Spillovers (TWiV 923 and 876) 38:42•Vincent: Giant viruses (TWiV 873, 906, 968) 41:50•Dickson: TWiV 960 – Getting Funky with Dan Wilson 48:17•Rich: TWiV 927: Merchlinsky vs monkeypox 56:50•Kathy: TWiV 958: Pass the RNA and have some venison pi 1:00:23•Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm 1:06:40•Twiverse 1:14:09•Letters read on TWiV 971 1:22:07•Timestamps by Jolene. Thanks! Weekly Picks 1:37:21 Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: DesafinadoBrianne – A Full Circle Rainbow over NorwayKathy – Frozen soap bubblesRich – It’s Turtles All the Way Down in the Fossil Record by Asher ElbeinVincent – Vincent’s Top Ten Music Listener Picks Charles – Wayne Bergeron and Vince DiMartino MacArthur Park Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 970: Clinical update with Dr. Daniel Griffin
TWiV 970: Clinical update with Dr. Daniel GriffinDecember 31, 2022In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up. Click arrow to playDownload TWiV 970 (31 MB .mp3, 52 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Modeling the adjustment of COVID-19 response and exit in China (Nature) 5:49 Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ) 10:02 N95 respirator failure caused by an overlying face mask (ICHE) 15:12 Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID) 16:13 Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID) 18:55 Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell) 21:21 VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM) 25:03 Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP) 28:35 Molnupiravir as early treatment for adults with COVID-19 (The Lancet) 31:25 Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv) 33:44 FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche) 35:41 Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals) 36:45 Paxlovid patient eligbiliity screening checklist (FDA) Persistent post–COVID-19 smell loss association (Science) 37:46 Epidemiology of long COVID in US adults (CID) 39:41 Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID) 40:55 Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv) 41:26 Contribute to our MicrobeTV fundraiser at PWB 44:52 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 970 45:27 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
Infectious Disease Puscast #18
Infectious Disease Puscast #18December 27, 2022On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 018 (22 MB .mp3, 37 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Human Rabies in Texas, 2021 (CDC) Human rabies despite post-exposure prophylaxis (The Lancet) The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet) An update on eukaryotic viruses revived from ancient permafrost (bioRx) Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM) Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID) Salmonella enteritidis cardiovascular implantable electronic device infection (OFID) Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID) Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID) Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID) Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID) Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID) Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID) Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID) Factors contributing to delayed academic advancement of women in infectious diseases (OFID) Characterization of problematic alcohol use among physicians (JAMA) Alpha-gal syndrome in the ID clinic (OFID) Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet) Music is by Ronald Jenkees [...] Read more...