TWiV 996: Clinical update with Dr. Daniel Griffin
TWiV 996: Clinical update with Dr. Daniel GriffinApril 1, 2023In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition. Click arrow to play Download TWiV 996 (24 MB .mp3, 40 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Antibiotics don’t reduce risk of death from viral respiratory infections (CIDRAP) ABO blood types and SARS-CoV-2 infection (Nature) Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization (Nature Medicine) Association of treatment with Nirmatrelvir and risk of post–COVID-19 (JAMA) Ventilated patients with COVID-19 had a higher chance of in-hospital death with usage of nasal cannula oxygen (IARS) High-flow nasal cannula and outcomes in COVID-19 (IARS) Severe infection and risk of cardiovascular disease (AHA) Risk factors associated with post−COVID-19 condition (JAMA) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 996 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiP 215: A mobile piece of spaghetti
TWiP 215: A mobile piece of spaghettiMarch 30, 2023TWiP solves the case of the case of the boy in Uganda with a mobile piece of spaghetti in the gallbladder, and reviews papers on female genital schistosomiasis in rural Madagascar, and a volatile sex attractant of tsetse flies. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiP #215 (49 MB .mp3, 81 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode •Female genital schistosomiasis in rural Madagascar (PLoS NTD)•A volatile sex attractant of tsetse flies (Science)•Letters read on TWiP 215 Become a patron of TWiP Case Study for TWiP 215 This case was shared with my by a former student of the Diploma in Tropical Medicine and Hygiene course I coordinate, Prof Eyal Leshem, who is the Director  of the Institute for Travel and Tropical Medicine at the Sheba Medical Center in Tel Aviv and Clinical Associate Professor at the School of Medicine at Tel Aviv University, Israel. This case is of a 24 year old male who presented to the emergency room at the end of February with a 4 day history of fever, starting three weeks after he returned from a long trip. He reports traveling in India during October of the past year. From November to early January, he stayed in Papua New Guinea, from where he traveled to Thailand, returning to Israel in early February. On admission he reports a daily fever up to 40 degrees C, which I think is 104 Fahrenheit. He also mentions an itchy rash and dry cough. We learn a bit more about this patient. In Thailand, he received a five-day course of doxycycline due to a febrile illness, which resolved after treatment. During his stay in Papua New Guinea he hiked in the jungle, was bitten by multiple insects and also report finding leeches attached to his lower legs. One insect bite on his hip took a while to heal. He also reports swimming in multiple rivers. While travelling, he did not have unprotected sexual encounters but he admits to eating street food and home made food regularly. He received pre-travel vaccines and when he was in Papua New Guinea took Atovaquone Proguanil prophylaxis daily, discontinuing therapy a week after he flew to Thailand. On physical exam he is alert and oriented, vitals normal, the examination is unremarkable except for three cropped vesicles on his penis, which the patients says are itchy. A healed insect bite on his lower hip is also noted. His white blood count and differential are normal without eosinophilia. His haemoglobin is 13 g/dl, which is borderline normal and his platelet count is lower than normal with a count of 100,000 per microlitre of blood. What is your diagnosis? What test or tests would you like to order to confirm your suspicion. We would like you to be as accurate as you can when identifying the parasite causing this man’s symptoms. What are special considerations you need to think about for treatment? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees [...] Read more...
TWiN 38: Bacterial immunity heals sensory neurons
TWiEVO 88: Dog days of evolution in the shadows of Chernobyl
TWiV 995: Viral origin stories
TWiV 995: Viral origin storiesMarch 26, 2023TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli Click arrow to playDownload TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 2:27•MicrobeTV Discord Server• More evidence for SARS-CoV-2 spillover (Zenodo) 7:31•Polio cases linked to nOPV2 (Science; GPEI statement) 26:12•nOPV2 on TWiV 756 30:21•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) 34:55•Stability of nOPV2 in children (npj Vaccines)•2A changes compensate for 5′-UTR disruptions (Virology) 41:01•HBV shifts from naked to enveloped (Nat Comm) 54:00•Letters read on TWiV 995 1:24:14•Timestamps by Jolene. Thanks! Weekly Picks 1:42:18 Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy HeathAngela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neuronsBrianne – Science Museums Take Stock of 1.1 Billion Objects from Around the WorldVincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York Listener Picks Gary – Tony Fauci on PBSStefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiM 283: Quorum sensing in the gut
TWiV 994: Clinical update with Dr. Daniel Griffin
TWiV 994: Clinical update with Dr. Daniel GriffinMarch 25, 2023In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity. Click arrow to play Download TWiV 994 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode cVDPV2 detections in Burundi and the DRC (PGEI) 4:53 Novel oral polio vaccine type 2 story (The Lancet) 7:00 Prior COVID-19 infection associated with risk of diagnosed erectile dysfunction (IJIR) 8:18 Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection (BMJ) 13:35 Protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals(The Lancet) 15:00 Effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths (The Lancet) 25:30 Projected COVID-19 mortality reduction from Paxlovid rollout (JAMA) SARS-CoV-2 mRNA vaccines decouple anti-viral immunity (Nature) 30:50 Contribute to our ASTMH fundraiser at PWB 36:10 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 994 36:38 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
Infectious Disease Puscast #24
Infectious Disease Puscast #24March 21, 2023On episode #24 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/1 – 3/22/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 023 (24 MB .mp3, 40 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Re-emergence of Parechovirus: 2017-2022 national trends of detection in CSF (OFID) Screening and testing for hepatitis B virus infection (CDC) Changing epidemiology of carbapenemases among carbapenem-Resistant Enterobacterales (OFID) Comparison of a short vs long-course antibiotic therapy for ventilator-associated pneumonia (eClinicalMedicine) The impact of timing of infectious disease consultation for Staphylococcus aureus bacteremia (CID) Intravenous doxycycline, azithromycin, or both for severe scrub typhus (NEJM) Cronobacter sakazakii infections in two infants linked to powdered infant formula and breast pump equipment (CDC) Piperacillin/tazobactam vs cefepime or carbapenems for cefoxitin-non-susceptible bacteraemia in immunocompromised patients (JAC) Positive impact of [18F) FDG-PET/CT on mortality in patients with Staphylococcus aureus bacteremia (CID) Association of antibody immunity with cryptococcal antigenemia and mortality in a South African cohort with advanced HIV (CID) Practical guide to antifungal susceptibility testing (JPIDS) Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) Emergence and Persistence of Candida auris in Western New York with no epidemiologic links (OFID) Music is by Ronald Jenkees [...] Read more...
TWiV 993: COVID-19 drives autoimmunity
TWiV 992: Clinical update with Dr. Daniel Griffin
TWiV 992: Clinical update with Dr. Daniel GriffinMarch 18, 2023In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment. &amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt; Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) 1:06 SARS-CoV-2 exposure in Norway rats from New York City (mBio) 3:28 Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS) 6:54 Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID) 8:37 Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet)  12:28 Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) 16:05 Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA) 18:14 Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) 21:47 Contribute to our ASTMH fundraiser at PWB 21:43 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 992 24:40 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiV 991: The cancer mRNA shot
TWiV 991: The cancer mRNA shotMarch 12, 2023On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice. &amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt; Click arrow to playDownload TWiV 991 (67 MB .mp3, 112 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 2:56•MicrobeTV Discord Server•1918 influenza virus not lethal in nonhuman primates (J Virol) 10:33•mRNA vaccines control HPV-associated tumors (Sci Trans Med) 40:19•Letters read on TWiV 991 1:16:52•Timestamps by Jolene. Thanks! Weekly Picks 1:42:39 Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke EllingtonRich – Protein synthesis: an epic on the cellular levelAlan – Thomas Was AloneVincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out Listener Pick Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 990: Clinical update with Dr. Daniel Griffin
TWiV 990: Clinical update with Dr. Daniel GriffinMarch 11, 2023In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19. &lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt; Click arrow to play Download TWiV 990 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Confronting the evolution and expansion of anti-vaccine activism (The Lancet) 1:17 Effectiveness of maternal influenza vaccination in Peru (OFID) 2:14 Characteristics and predictors of persistent symptoms post-COVID-19 (BMJ) 4:11 Parental nonadherence to health policy recommendations for prevention of COVID-19 (JAMA) 6:11 Community-onset bacterial coinfection in children ill with SARS-CoV-2 infection (OFID) 7:47 Bivalent booster effectiveness against severe COVID-19 outcomes (medRxiv) 9:56 Viral kinetics of sequential SARS-CoV-2 infections (medRxiv) 10:46 Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) 13:50 Immunomodulators for severe COVID-19 in transplant patients (TID) 15:37 Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population (eClinicalMedicine) 17:00 Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection (BMJ) 18:54 One year adverse outcomes among US adults with post COVID-19 condition vs those without COVID-19 (JAMA) 19:33 Long-term gastrointestinal outcomes of COVID-19 (Nature) 21:04 Contribute to our ASTMH fundraiser at PWB 22:19 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 990 22:51 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiM 282: At-home evolution with yeast
Infectious Disease Puscast #23
Infectious Disease Puscast #23March 7, 2023On episode #23 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/16 – 2/28/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 023 (24 MB .mp3, 40 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Association between cytomegalovirus infection and tuberculosis disease (JID) In-depth virological and immunological characterization of HIV-1 cure after allogeneic hematopoietic stem cell transplantation (Nature) Algorithm-based Clostridioides difficile testing as a tool for antibiotic stewardship (CMI) Clinical utility of nasal surveillance swabs in ruling-out MRSA infections in children (JPIDS) Antimicrobial for 7 or 14 days for febrile UTI in men (CID) Treatment strategy for rifampin-susceptible TB (NEJM) Current pyuria cut-offs promote inappropriate UTI diagnosis in older women (CID) Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults (CID) Hospitalizations for unspecified mycoses and implications for fungal disease burden estimates (OFID) Invasive mold infections following Hurricane Harvey (OFID) Cryptococcal meningitis and clinical outcomes in persons with HIV (CID) Rapid range shifts in African Anopheles mosquitoes over the last century (Biology Letters) Neuroangiostrongyliasis: Rat lungworm invades Europe (ASTMH) Balamuthia mandrillaris encephalitis presenting as a symptomatic focal hypodensity in an immunocompromised patient (OFID) Low rates of antibiotics prescribed during telehealth primary-care visits persisted during COVID19 (ICHE) Music is by Ronald Jenkees [...] Read more...
TWiV 989: Antibody cross-reactivity is metal
TWiV 989: Antibody cross-reactivity is metalMarch 5, 2023TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to playDownload TWiV 989 (67 MB .mp3, 112 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 2:11•MicrobeTV Discord Server•Paul Berg obituary 3:44•Spike mRNA in blood (J Path Micro Imm) 12:21•Spike mRNA in blood (Biomedicine) 27:37•Cross-protective mAbs against respiratory viruses (Nat Comm) 31:21•RSV prefusion F protein vaccine in older adults (NEJM) 1:06:31•Ad26.RSV.preF–RSV preF protein vaccine (NEJM) 1:09:16•Letters read on TWiV 989 1:17:33•Timestamps by Jolene. Thanks! Weekly Picks 1:32:08 Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet).Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal PandemicKathy – “That’s What They Say” podcast about pronunciation of “primer.”Rich – Slow motion art:  1 and 2Vincent – Grammarly Listener Pick Charles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’ Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 988: Clinical update with Dr. Daniel Griffin
TWiV 988: Clinical update with Dr. Daniel GriffinMarch 4, 2023In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.  Click arrow to play Download TWiV 988 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA) 3:07 Monoclonal antibody for the prevention of RSV in infants and children (JAMA) 8:06 Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC) 15:13 COVID-19 vaccines vs pediatric hospitalization (Cell) 17:56 Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature) 18:15 Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet) 20:21 Fatal Fulminant Cerebral Edema in children with SARS-CoV-2 Omicron BA.2 infection (JPID) 21:22 Certifying deaths due to COVID-19 (CDC) 29:02 Efficacy of first dose of COVID-19 vaccine vs no vaccination on patients with Long COVID (BMJ) 29:55 Effect of COVID-19 vaccination on long COVID (BMJ) 30:08 Contribute to our ASTMH fundraiser at PWB 30:55 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 988 31:43 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiP 214: Tropical medicine excursions with Kay Schaefer
TWiV 987: Convalescing with Casadevall
TWiV 986: Clinical update with Dr. Daniel Griffin
TWiV 986: Clinical update with Dr. Daniel GriffinFebruary 25, 2023In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.  Click arrow to playDownload TWiV 986 (26 MB .mp3, 43 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RSV prefusion F protein vaccine in older adults (NEJM) 1:19 Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM) 5:38 Health care vaccine mandate remains as some push for an end (AP) 8:21 Past SARS-CoV-2 infection protection against re-infection (The Lancet) 10:51 A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv) 16:26 Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv) 18:38 Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA) 21:43 Viral burden rebound in patients with COVID-19 receiving oral antivirals (The Lancet)  Serological response to vaccination in post-acute sequelae of COVID (BMC) 26:05 Sex differences in cardiovascular complications and mortality in patients with COVID-19 (BMI) 27:21 Association of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA) 28:13 Postacute sequelae of SARS-CoV-2 in university setting (CDC) 30:00 The CDC’s Long-Covid deception (WSJ) 33:52 Podcast companies, once walking on air, feel the strain of gravity (NYT) 35:34 Contribute to our ASTMH fundraiser at PWB 36:11 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 986 36:40 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiEVO 87: Nathan Clark’s revolutionary hair care advice

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