TWiV 994: Clinical update with Dr. Daniel Griffin
TWiV 994: Clinical update with Dr. Daniel GriffinMarch 25, 2023In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity. Click arrow to play Download TWiV 994 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode cVDPV2 detections in Burundi and the DRC (PGEI) Novel oral polio vaccine type 2 story (The Lancet) Prior COVID-19 infection associated with risk of diagnosed erectile dysfunction (IJIR) Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection (BMJ)  Protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals(The Lancet) Effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths (The Lancet) Projected COVID-19 mortality reduction from Paxlovid rollout (JAMA) SARS-CoV-2 mRNA vaccines decouple anti-viral immunity (Nature)  Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 994 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
Infectious Disease Puscast #24
Infectious Disease Puscast #24March 21, 2023On episode #24 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/1 – 3/22/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 023 (24 MB .mp3, 40 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Re-emergence of Parechovirus: 2017-2022 national trends of detection in CSF (OFID) Screening and testing for hepatitis B virus infection (CDC) Changing epidemiology of carbapenemases among carbapenem-Resistant Enterobacterales (OFID) Comparison of a short vs long-course antibiotic therapy for ventilator-associated pneumonia (eClinicalMedicine) The impact of timing of infectious disease consultation for Staphylococcus aureus bacteremia (CID) Intravenous doxycycline, azithromycin, or both for severe scrub typhus (NEJM) Cronobacter sakazakii infections in two infants linked to powdered infant formula and breast pump equipment (CDC) Piperacillin/tazobactam vs cefepime or carbapenems for cefoxitin-non-susceptible bacteraemia in immunocompromised patients (JAC) Positive impact of [18F) FDG-PET/CT on mortality in patients with Staphylococcus aureus bacteremia (CID) Association of antibody immunity with cryptococcal antigenemia and mortality in a South African cohort with advanced HIV (CID) Practical guide to antifungal susceptibility testing (JPIDS) Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) Emergence and Persistence of Candida auris in Western New York with no epidemiologic links (OFID) Music is by Ronald Jenkees [...] Read more...
TWiV 993: COVID-19 drives autoimmunity
TWiV 992: Clinical update with Dr. Daniel Griffin
TWiV 992: Clinical update with Dr. Daniel GriffinMarch 18, 2023In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) 1:06 SARS-CoV-2 exposure in Norway rats from New York City (mBio) 3:28 Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS) 6:54 Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID) 8:37 Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet)  12:28 Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) 16:05 Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA) 18:14 Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) 21:47 Contribute to our ASTMH fundraiser at PWB 21:43 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 992 24:40 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiV 991: The cancer mRNA shot
TWiV 991: The cancer mRNA shotMarch 12, 2023On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to playDownload TWiV 991 (67 MB .mp3, 112 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 2:56•MicrobeTV Discord Server•1918 influenza virus not lethal in nonhuman primates (J Virol) 10:33•mRNA vaccines control HPV-associated tumors (Sci Trans Med) 40:19•Letters read on TWiV 991 1:16:52•Timestamps by Jolene. Thanks! Weekly Picks 1:42:39 Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke EllingtonRich – Protein synthesis: an epic on the cellular levelAlan – Thomas Was AloneVincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out Listener Pick Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 990: Clinical update with Dr. Daniel Griffin
TWiV 990: Clinical update with Dr. Daniel GriffinMarch 11, 2023In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 990 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Confronting the evolution and expansion of anti-vaccine activism (The Lancet) 1:17 Effectiveness of maternal influenza vaccination in Peru (OFID) 2:14 Characteristics and predictors of persistent symptoms post-COVID-19 (BMJ) 4:11 Parental nonadherence to health policy recommendations for prevention of COVID-19 (JAMA) 6:11 Community-onset bacterial coinfection in children ill with SARS-CoV-2 infection (OFID) 7:47 Bivalent booster effectiveness against severe COVID-19 outcomes (medRxiv) 9:56 Viral kinetics of sequential SARS-CoV-2 infections (medRxiv) 10:46 Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) 13:50 Immunomodulators for severe COVID-19 in transplant patients (TID) 15:37 Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population (eClinicalMedicine) 17:00 Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection (BMJ) 18:54 One year adverse outcomes among US adults with post COVID-19 condition vs those without COVID-19 (JAMA) 19:33 Long-term gastrointestinal outcomes of COVID-19 (Nature) 21:04 Contribute to our ASTMH fundraiser at PWB 22:19 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 990 22:51 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiM 282: At-home evolution with yeast
Infectious Disease Puscast #23
Infectious Disease Puscast #23March 7, 2023On episode #23 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/16 – 2/28/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 023 (24 MB .mp3, 40 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Association between cytomegalovirus infection and tuberculosis disease (JID) In-depth virological and immunological characterization of HIV-1 cure after allogeneic hematopoietic stem cell transplantation (Nature) Algorithm-based Clostridioides difficile testing as a tool for antibiotic stewardship (CMI) Clinical utility of nasal surveillance swabs in ruling-out MRSA infections in children (JPIDS) Antimicrobial for 7 or 14 days for febrile UTI in men (CID) Treatment strategy for rifampin-susceptible TB (NEJM) Current pyuria cut-offs promote inappropriate UTI diagnosis in older women (CID) Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults (CID) Hospitalizations for unspecified mycoses and implications for fungal disease burden estimates (OFID) Invasive mold infections following Hurricane Harvey (OFID) Cryptococcal meningitis and clinical outcomes in persons with HIV (CID) Rapid range shifts in African Anopheles mosquitoes over the last century (Biology Letters) Neuroangiostrongyliasis: Rat lungworm invades Europe (ASTMH) Balamuthia mandrillaris encephalitis presenting as a symptomatic focal hypodensity in an immunocompromised patient (OFID) Low rates of antibiotics prescribed during telehealth primary-care visits persisted during COVID19 (ICHE) Music is by Ronald Jenkees [...] Read more...
TWiV 989: Antibody cross-reactivity is metal
TWiV 989: Antibody cross-reactivity is metalMarch 5, 2023TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to playDownload TWiV 989 (67 MB .mp3, 112 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 2:11•MicrobeTV Discord Server•Paul Berg obituary 3:44•Spike mRNA in blood (J Path Micro Imm) 12:21•Spike mRNA in blood (Biomedicine) 27:37•Cross-protective mAbs against respiratory viruses (Nat Comm) 31:21•RSV prefusion F protein vaccine in older adults (NEJM) 1:06:31•Ad26.RSV.preF–RSV preF protein vaccine (NEJM) 1:09:16•Letters read on TWiV 989 1:17:33•Timestamps by Jolene. Thanks! Weekly Picks 1:32:08 Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet).Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal PandemicKathy – “That’s What They Say” podcast about pronunciation of “primer.”Rich – Slow motion art:  1 and 2Vincent – Grammarly Listener Pick Charles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’ Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 988: Clinical update with Dr. Daniel Griffin
TWiV 988: Clinical update with Dr. Daniel GriffinMarch 4, 2023In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.  Click arrow to play Download TWiV 988 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA) 3:07 Monoclonal antibody for the prevention of RSV in infants and children (JAMA) 8:06 Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC) 15:13 COVID-19 vaccines vs pediatric hospitalization (Cell) 17:56 Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature) 18:15 Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet) 20:21 Fatal Fulminant Cerebral Edema in children with SARS-CoV-2 Omicron BA.2 infection (JPID) 21:22 Certifying deaths due to COVID-19 (CDC) 29:02 Efficacy of first dose of COVID-19 vaccine vs no vaccination on patients with Long COVID (BMJ) 29:55 Effect of COVID-19 vaccination on long COVID (BMJ) 30:08 Contribute to our ASTMH fundraiser at PWB 30:55 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 988 31:43 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiP 214: Tropical medicine excursions with Kay Schaefer
TWiV 987: Convalescing with Casadevall
TWiV 986: Clinical update with Dr. Daniel Griffin
TWiV 986: Clinical update with Dr. Daniel GriffinFebruary 25, 2023In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.  Click arrow to playDownload TWiV 986 (26 MB .mp3, 43 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RSV prefusion F protein vaccine in older adults (NEJM) 1:19 Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM) 5:38 Health care vaccine mandate remains as some push for an end (AP) 8:21 Past SARS-CoV-2 infection protection against re-infection (The Lancet) 10:51 A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv) 16:26 Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv) 18:38 Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA) 21:43 Viral burden rebound in patients with COVID-19 receiving oral antivirals (The Lancet)  Serological response to vaccination in post-acute sequelae of COVID (BMC) 26:05 Sex differences in cardiovascular complications and mortality in patients with COVID-19 (BMI) 27:21 Association of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA) 28:13 Postacute sequelae of SARS-CoV-2 in university setting (CDC) 30:00 The CDC’s Long-Covid deception (WSJ) 33:52 Podcast companies, once walking on air, feel the strain of gravity (NYT) 35:34 Contribute to our ASTMH fundraiser at PWB 36:11 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 986 36:40 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiEVO 87: Nathan Clark’s revolutionary hair care advice
Infectious Disease Puscast #22
Infectious Disease Puscast #22February 21, 2023On episode #22 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/2 – 2/15/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 022 (23 MB .mp3, 38 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Influence of rapid influenza diagnostic testing on clinician decision-making for patients with acute respiratory infection (CID) Outbreak of extensively drug-resistant Pseudomonas aeruginosa (CDC) Epidemiology and clinical outcomes of non-HACEK gram-negative infective endocarditis (OFID) Azithromycin to prevent sepsis or death in women planning a vaginal birth (NEJM) Clinical significance of concomitant bacteruria in patients with Staphylococcus aureus bacteremia (EJCM) Health disparities in hemodialysis associated Staph aureus bloodstream infections (CDC) Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteremia (CMI) Genome-wide analysis of transposon mobility in the human fungal pathogen Cryptococcus deneoformans (PNAS) Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia (CID) Prevalence of Ocular Complications in candidemia (CID) Rapid and spontaneous post-partum clearance of Plasmodium falciparum (JID) Adoption and utilization of social media among adult and pediatric infectious diseases divisions and fellowship programs (OFID) Canine detection of chronic wasting disease in laboratory and field settings (Prion) Music is by Ronald Jenkees [...] Read more...
Immune 65: Infection infidelities with Jonathan Kagan
TWiM 281: Microbes making jet fuel
TWiV 985: Bambi’s revenge
TWiV 985: Bambi’s revengeFebruary 19, 2023TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern.   Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Click arrow to playDownload TWiV 985 (66 MB .mp3, 109 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 1:34•MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Guinea (WHO) 4:43•Wild-type poliovirus type 3 from laboratory (Eurosurveillance) 13:47•Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS) 33:25•Letters read on TWiV 985 1:12:25•Timestamps by Jolene. Thanks! Weekly Picks 1:25:13 Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara).  Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park.Rich – The American Phage Group: Founders of Molecular Biology by William C. SummersVincent – DJ Miss Monique aka Olesia Arkusha Listener Pick Megan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...
TWiV 984: Clinical update with Dr. Daniel Griffin
TWiV 984: Clinical update with Dr. Daniel GriffinFebruary 18, 2023In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19. Click arrow to playDownload TWiV 984 (26 MB .mp3, 43 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The political polarization of COVID-19 treatments in the United States (PNAS) 1:12 Seven alternatives to evidence-based medicine (BMJ) 4:54 Malawi’s cholera death toll crosses 1,300 (CBC) 6:21 Impact of coronavirus infections on pediatric patients (JHI) 9:37 Maternal mRNA COVID-19 vaccination during pregnancy (BMJ) 11:43 Yes, masks reduce the risk of spreading COVID (TVO) 13:29 COVID-19 and airborne transmission (IDSA) 15:50 What were the reasons for resistance to recognizing airborne transmission (IJIE) 16:02 Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv) 17:11 SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv) 21:10 The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature) 24:56 Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM) 28:24 Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet) 29:34 Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet) 31:54 Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID) 33:18 Contribute to our ASTMH fundraiser at PWB 37:15 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 984 37:37 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...
TWiV 983: One flu vaccine for them all with Scott Hensley

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