In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. post
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. post
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. post
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. post
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients. post
TWiM continues its food arc with an examination of the effect of peroxyacetic acid spray on the microbiome and sensory properties of beef, and explores asymmetry of the cell division machinery during sporulation. post
Christina returns to the TWiP trifecta to solve the case of the Beachgoer with Red Lines on Her foot, and an experimental malaria vaccine based on the junctional region of the circumsporozoite protein displayed on a virus-like particle. post
Nels and Vincent explain a new method for calculating the most recent common ancestor of SARS-CoV-2, which concludes that the ancestral virus was circulating in October/November 2019, before its first detection in China. post
TWiM reveals the microbiome of sourdough starter cultures, and discovery of a novel family of prokaryotic nanocompartments involved in the metabolism of sulfur. post
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. post
TWiM explains how Vibrio biofilms are dispersed by polyamine signals, and the induction of inappetence by respiratory virus infection which causes alteration of the gut microbiome. post
TWiM reviews aspirin modulation of Fusobacterium nucleatum, a microbe that has been associated with colorectal cancer, and Elio tells us ‘What are vaccines’, a talk he recently gave to members of his community. post
TWiP solves the case of the Long Island Man with Unilateral Eye Pain, followed by a discussion of how enteric helminth coinfection enhances host susceptibility to West Nile virus by a tuft cell-IL-4 receptor signaling axis. post
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. post
Audun returns to help solve the case of the Ecuadorean Gentleman Treated for COVID-19, followed by a discussion of the interaction of Blastocystis with the intestinal microbiota and the immune system, and of course a new clinical case from Daniel. post
Nels and Vincent review a preprint demonstrating that changes in the genomes of the SARS-CoV-2 variants B1.351 and P.1 allow the viruses to reproduce in mouse cells in culture and in laboratory mice. post
On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. post
Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators. post
Nels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern. post
Daniel joins Dickson and Vincent to talk about the Vertical Farm Institute, which provides advice and planning on the design and construction of indoor farms. post
In this episode of Virus Watch, we explore the finding that Zika virus infects the testis of mice, causing damage to the organ, reduced sperm production, and less fertility. The important question: does the same happen in humans? post
Dickson and Vincent speak with Robert Colangelo, founding farmer and CEO of Green Sense Farms, the world's largest commercial indoor vertical farm. post
