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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson’s disease
May 24, 2022
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Click arrow to playDownload TWiN 030 (44 MB .mp3, 74 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Gut-brain alpha-synuclein transport in PD (Neuron)Gut has a mind of its own (Colbert Report)Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
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TWiV 902: Autoantibodies drive severe COVID-19
May 22, 2022
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 902 (76 MB .mp3, 127 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) 6:43Possible monkeypox in NYC (NY Times)Occupational monkeypox, Wisconsin (Emerg Inf Dis) 13:45SARS-CoV-2 in feces (Nature) 18:35IFN autoantibodies and severe COVID-19 (PNAS) 30:11Letters read on TWiV 902 1:08:44Timestamps by Jolene. Thanks! Weekly Picks 1:48:18 Dickson – How to grow food on the moonBrianne – APod May 16: Milky Way over French Alp HoodoosKathy – Covid Nationwide data visualizationRich – NIH All of Us Research ProgramVincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine? Listener Pick Lisa – E.H. Danner Museum of Telephony Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv...
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TWiM 265: Antiviral hotspots and desiccation tolerance
May 21, 2022
TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted by hydrophilins. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Right click to download TWiM #265 (41 MB .mp3, 57 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Phage and satellite antiviral systems (Cell Host Micro)Hydropilins promote desiccation tolerance (Cell Host Micro)Letters read on TWiM 265 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv...
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TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
May 21, 2022
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Click arrow to playDownload TWiV 901 (36 MB .mp3, 60 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccination (Nature) 7:01EUA for boosters in 5-11 year olds (FDA) 8:02Stages of COVID-19 (AIDS Rev) 8:40B.1.1.529 attack rate in Australia (JID) 11:13Scent dogs (BMJ) 16:11Does Omicron affect pets? (CVMBS News) 18:59Paxlovid eligibility checklist (FDA) 23:02Supratherapeutic tacrolimus with nirmatrelvir/ritonavir (Op For Inf Dis) 24:33Is longer Paxlovid needed? (Reuters) 26:01How about Veklury? (Gilead) 28:02Fluvoxamine declined (FDA) 31:14Antigen positivity after isolation (MMWR) 36:26Inflammasome activation drives COVID-19 pathology (TWiV 900, Nature) 50:40PASC and viral antigen persistence in gut (Gastroenterol) 53:11GI symptoms and fecal shedding (Med) 51:42Contribute to ASTMH fundraiser at PW 56:48Dr. Griffin’s treatment guide (pdf)Letters read on TWiV 901 57:21Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv...
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Infectious Disease Puscast #2
May 17, 2022
On the the second episode of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/27/22 – 5/11/22. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 002 (33 MB .mp3, 54 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode •Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 (MMWR)•Case Series of False-Positive HIV Test Results in Pediatric Acute Lymphoblastic Leukemia Patients Following Chimeric Antigen Receptor T-Cell Therapy: Guidance on How to Avoid and Resolve Diagnostic Dilemmas (JPIDS)•Immunological correlates of prevention of the onset of seasonal H3N2 influenza (JID)•Use of a Modified Preexposure Prophylaxis Vaccination Schedule to Prevent Human Rabies: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 (MMWR)•Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults(MMWR)•The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children (JPIDS)•Factors Potentially Contributing to the Contamination of Packaged Leafy Greens Implicated in the Outbreak of Salmonella Typhimurium During the Summer of 2021 (FDA)•Short-course intravenous antibiotics for young infants with urinary tract infection (Arch Dis Children)•Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence (Clin Inf Dis)•2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults (Clin Inf Dis)•Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa (Lancet)•Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults (JAMA)•Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management (Clin Inf Dis)•Frequency and Duration of, and Risk Factors for, Diagnostic Delays Associated with Histoplasmosis (J Fungi)•Intestinal parasitic infections and associated factors among people living with HIV attending Dessie Referral Hospital, Dessie town, North-east Ethiopia (AIDS Res Ther)•Association of zoonotic protozoan parasites with microplastics in seawater and implications for human and wildlife health (Nat Sci Rep)•Climate change increases cross-species viral transmission risk (Nature and TWiV 898) Intro music is by Ronald JenkeesSend your questions for Puscast to puscast@microbe.tv...
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TWiV 900: Burning down the mouse
May 15, 2022
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 900 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture 8:07Infected macrophages drives severe COVID-19 (Nature) 17:50Timestamps by Jolene. Thanks! Weekly Picks 1:17:45 Brianne – The Milky Way’s Black Hole Comes to LightKathy – River dolphins playing with anacondaRich – Smallpox vaccination techniques; from knives and forks to needles and pinsAlan – Vacuum Tubes: a Modern Aladdin’s LampVincent – Books by Pamela Jane Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv...
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TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
May 14, 2022
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Click arrow to playDownload TWiV 899 (34 MB .mp3, 56 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) 36:01Procalcitonin not a reliable biomarker (IDSA) 43:08Evaluation of vaccine in children 6 to 11 years (NEJM) 2:40FDA limits use of Janssen vaccine (FDA) 24:48Recall of B cell memory on vaccination location (Science Immunology) 26:22Persistence screening using sniffer dogs (Journal of Clinical Trials) 13:24Tixagevimab/Cilgavimab for treatment of hospitalized patients (Lancet) 28:13Infection detection by canine olfaction (OFID) 10:40Diagnostic utility to differentiate patients (IDSA) 43:55Prevalence of anosmia in pediatric cases (Pediatric Infectious Disease Journal) 7:22Risk assessment for public events (University of Texas COVID-19 Modeling Consortium) 17:03PAXLOVID patient eligibility screening checklist (FDA) 33:01PAXLOVID drug interactions (IDSA) 34:36Contribute to ASTMH fundraiser at PWB 48:05Dr. Griffin’s treatment guide (pdf)Letters read on TWiV 899 48:41Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv...
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TWiV 898: Immunity is skin deep
May 8, 2022
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 898 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) 2:58Smallpox vaccination increases skin bacteria (PLoS Path) 27:29The invinceable TWiV (TWiV 145) 36:29By the pricking of my thumbs… (TWiV 284) 36:43Letters read on TWiV 898 1:10:06Timestamps by Jolene. Thanks! Weekly Picks 1:27:50 Brianne – Bacteria and Me Coloring BookKathy – Smarter 3D printingRich – Big Ben Restoring the Worlds Most Famous Clock 2021Vincent – Scientific review articles as antivaccine disinformation Listener Pick Suellen – Your Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode) Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv...
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TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin
May 7, 2022
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Click arrow to playDownload TWiV 897 (29 MB .mp3, 48 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Timing of Tocilizumab Use in Hospitalized Patients (NIH) 34:28Interleukin-6 inhibitors reduce mortality (European Journal of Internal Medicine) 35:58Treatment Effect of Baricitinib on Hospitalized Patients (IDSA) 36:57Post Infection Neurological Sequelae (Res Square) 38:09Comparative Effectiveness of Pfizer and Moderna Vaccines (Nature Commun) 7:58Results from Phase 2/3 Study of Paxlovid (Pfizer) 13:45Infection Relapse Following Suppression by Paxlovid (Res Square) 19:55Update on Paxlovid Usage (FDA) 25:02Availability and Use of Treatments in Outpatients (CDC) 25:47Pre-Hospital Administration of Remdesivir (IDSA) 26:56Remdesivir and three other drugs for Hospitalized Patients (Lancet) 32:45Guidelines on Usage of Anticoagulants (Am Soc Hematol) 30:22Different Variants Hospitalization and Morality (Res Square) 3:30Contribute to FIMRIC fundraiser at PWB 40:26Dr. Griffin’s treatment guide (pdf)Letters read on TWiV 897 41:25Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv...
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TWiM 264: Antimicrobial antipsychotics
May 6, 2022
TWiM reveals that the atypical antipsychotic quetiapine promotes multiple antibiotic resistance in E. coli, and treatment with Bifidobacterium lactis probiotic benefits patients with coronary artery disease. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Right click to download TWiM #264 (48 MB .mp3, 66 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Antipsychotic promotes antimicrobial resistance (J Bact)Probiotic benefits patients with coronary artery disease (mSystems)B. lactis and Alzheimer’s in mice (Eur J Nutr)Letters read on TWiM 264 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv...
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Infectious Disease Puscast #1
May 5, 2022
On the first episode of the Infectious Disease Puscast, Daniel and Sara bring Marc Crislip’s well known Puscast back to life, and present a review of the infectious disease literature for the previous two weeks, 4/13 – 4/27/22. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 001 (33 MB .mp3, 54 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Rabies from an anteater (MMWR)Oral Tebipenem Pivoxil Hydrobromide in Complicated UTI (NEJM)Therapeutic monitoring of vancomycin for serious MRSA infections (IDSA)Time to retire Vancomycin for MRAS Endovascular Infections? (Op Forum Inf Dis)Impact of ID consultation on outcome of patients with enterococcal bacteremia (Op Forum Inf Dis)Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia (JAMA)Effect of Antimicrobial Prophylaxis Duration on Health Care-Associated Infections After Clean Orthopedic Surgery (JAMA)Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection (Op Forum Inf Dis)Vehicle Windshield Wiper Fluid as Potential Source of Sporadic Legionnaires’ Disease in Commercial Truck Drivers (EID)Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM)High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine (JID)Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d’Ivoire (J Inf Dis) Intro music is by Ronald JenkeesSend your questions for Puscast to puscast@microbe.tv...
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TWiP 205: Two for the price of one
May 3, 2022
The TWiP team solves the case of the Pregnant Ghanian Living Near a River, and reveal emodepside, a drug for treatment of onchocerciasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Click arrow to playDownload TWiP #205 (56 MB .mp3, 93 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Emodepside for onchocerciasis (PlOS NTD)Hero: Dr. Mwelecele Ntuli MalecelaLetters read on TWiP 205 Become a patron of TWiP Case Study for TWiP 205 Two women, 80s and 50s. Former had 9 children, lives in Ghanian village with large lagoon, many mosquitoes. Concerned about chronic swelling of left leg, groin area for much of her life. Walks barefoot. 50 yo with 4 children, both legs started to swell, cold, mosquito bites. With time left leg becomes hard, swollen, disfigured. Has gone to hospital for ulceration. Common problem in her village, mostly women but some men. Problems getting access to medications. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees...
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