The Latest Podcasts in the Microbe.TV Network

TWiV Special: One COVID vaccine for them all with Paul OffitFebruary 3, 2023Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Click arrow to playDownload TWiV Special (23 MB .mp3, 39 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA briefing document (pdf) Effectiveness of bivalent booster against severe infection (NEJM) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 979: Flushing out the viroidsJanuary 29, 2023TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems. . Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to playDownload TWiV 979 (63 MB .mp3, 105 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 1:58•Register for ASV 2023 2:45•MicrobeTV Discord Server 4:53•Nick Muzyczka passes 1:31:39•Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) 10:51•Vast world of viroid-like RNAs (Cell) 29:35•Letters read on TWiV 979 1:12:54•Timestamps by Jolene. Thanks! Weekly Picks 1:30:24 Kathy – 3B new Milky Way objects, Green cometRich – Virology under the Microscope—a Call for Rational DiscourseAlan – Indie story-driven games series #3: Valiant Hearts: The Great WarVincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf Listener Picks Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article) Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 978: Clinical update with Dr. Daniel GriffinJanuary 28, 2023In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Click arrow to playDownload TWiV 978 (24 MB .mp3, 39 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) 1:35 Preprint review should form part of PhD programmes and postdoc training (Nature) 3:16 Early and increased Influenza activity among children (CDC) 4:27 COVID-19 vaccines versus pediatric hospitalization (Cell) 8:10 SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) 10:31 Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) 12:47 Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) 14:21 Effects of Dexamethasone use among patients with COVID-19 (IJID) 24:42 Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ) 26:04 Contribute to our MicrobeTV fundraiser at PWB 28:52 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 978 29:25 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

Infectious Disease Puscast #20January 25, 2023On episode #20 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/4/23 – 1/17/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 020 (17 MB .mp3, 29 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Neuroinvasive West Nile infection in solid organ transplant recipients (TID) Clinical markers of post-Chikungunya chronic inflammatory joint disease (PLOSNTD) Cholera outbreak in Haiti (CDC) Legionella bononiensis isolated from a hotel water in Nothern Italy (MS) Contemporary pharmacotherapies for nontuberculosis mycobacterial infections (IDT) Defining the optimal duration of therapy for hospitalized patients with UTIs and Bacteremia (CID) Fidaxomicin to prevent recurrent Clostridioides difficile (JAC) Evaluating predictive value of resected proximal bone margins in Diabetic Foot Osteomyelitis(OFID) Postoperative inflammation and fever after elective aortic valve and aortic root replacement (OFID) Fungal nomenclature: managing change is the name of the game (OFID) Clinical microbiology laboratories should use nomenclature based on current taxonomy (JCM) Race and ethnicity: risk factors for fungal infections (PLOS) Mosquito net use in early childhood and survival to adulthood in Tanzania (NEJM) Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand (The Lancet) Music is by Ronald Jenkees [...] Read more...

Immune 64: A tangled web of wiresJanuary 23, 2023Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Click arrow to playDownload Immune 64 (66 MB .mp3, 110 min)Subscribe (free): Apple Podcasts, Google Podcasts. RSS, emailBecome a patron of Immune! Links for this episode MicrobeTV Discord Server Tangled web of wires (Nature) 2:07 Path to group A Streptococcus vaccines (Clin Inf Dis) 18:39 Immune end-types predictive of vaccine responses (Nat Immunol) 25:12 IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol) 35:14 Very bad B cells (Immunity) 44:11 Two epitope Streptococcus monoclonal (EMBO Mol Med) 59:33 Predictor of vaccine-induced antibody responses (Nat Immunol) 1:08:44 Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med) 1:18:25 Neutrophilic inflammation and RSV infection (Science) 1:23:24 Commensals avoiding recognition (Sci Immunol) 1:30:17 Continuous germinal center invasion and immune response diversity (Cell) 1:35:22 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen MedicalSend your immunology questions and comments to immune@microbe.tv [...] Read more...

TWiN 37: Microglia at the crossroadsJanuary 23, 2023TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Click arrow to playDownload TWiN 036 (45 MB .mp3, 75 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Microglia states and nomenclature (Nature) 4:12 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv [...] Read more...

TWiV 977: Ageing is infectiousJanuary 22, 2023TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Click arrow to playDownload TWiV 977 (63 MB .mp3, 105 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:27•Register for ASV 2023 3:10•MicrobeTV Discord Server 4:15•Persistence of SARS-CoV-2 (Nature) 6:13•Endogenous retroviruses and senescence (Cell) 29:55•Timestamps by Jolene. Thanks! Weekly Picks 1:26:32 Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s TuneAngela – World’s Longest AnimalBrianne – Green Comet to Pass By Earth for first time in 50,000 yearsAlan – Indie games series: Golf Club WastelandVincent – Bivalent Covid-19 Vaccines — A Cautionary Tale Listener Picks Lisa – The River and the Wall Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 976: Clinical update with Dr. Daniel GriffinJanuary 21, 2023In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. Click arrow to playDownload TWiV 976 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China records almost 60,000 COVID-related deaths (SCMP) 6:05 Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature) 9:46 Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA) 15:18 Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID) 19:51 Long COVID outcomes at one year after mild infection (BMJ) 24:38 Major findings, mechanisms and recommendations for Long COVID (Nature) 25:30 Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI) 27:36 Effect of using a structured pacing protocol (JMV) 30:00 Contribute to our MicrobeTV fundraiser at PWB 33:07 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 976 33:30 Don’t crush Paxlovid (pdf) 33:38 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiM 279: A road map for successful phage therapyJanuary 19, 2023TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Right click to download TWiM #279 (36 MB .mp3, 59 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Phage therapy against M. abscessus lung infection (Cell) Encapsulation of the septal cell wall protects S. pneumoniae from host defenses (PLoS Path) Letters read on TWiM 279 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv [...] Read more...

TWiV 975: Crossing the Ts with Daniela WeiskopfJanuary 15, 2023Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Daniela Weiskopf Click arrow to playDownload TWiV 975 (58 MB .mp3, 98 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:47•Register for ASV 2023 3:36•Cross reactive T cells to SARS-CoV-2 (Science) 25:50•SARS-CoV-2 exposure history and T cell response (Cell Rep Med) 42:13•Spike T cells cross- recognize Omicron (Nature) 45:05•Ancestral SARS-CoV-2 T cells recognize Omicron (Nature)•NVX-CoV2373 induces T cell responses (J Clin Inves) 47:23•Letters read on TWiV 975 1:09:34•Timestamps by Jolene. Thanks! Weekly Picks 1:26:29 Brianne – Video of viral attachment (based on this article)Alan – Starting a series of innovative indie video games. First up: The Longing.Vincent – The Amy Papers and Calendar for live events Listener Picks Judy – Innate immune evasion strategies of SARS-CoV-2Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 974: Clinical update with Dr. Daniel GriffinJanuary 14, 2023In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection. Click arrow to playDownload TWiV 974 (28 MB .mp3, 47 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 more widespread in animals than thought (Nat Geo) 12:34 Increasing ventilation reduces airborne transmission in schools (Frontiers) 14:31 Carbon dioxide monitoring to assess ventilation at a NID conference (CID) 15:58 Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet) 18:39 Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet) 23:49 Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ) 29:29 Contribute to our MicrobeTV fundraiser at PWB 35:28 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 974 36:31 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

Infectious Disease Puscast #19January 10, 2023On episode #19 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/22/22 – 1/3/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 019 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Burden of postinfectious symptoms after Acute Dengue (EID) Maribavir for CMV treatment in the real world (OFID) 24-Week all-oral regimen for Rifampin-Resistant Tuberculosis (NEJM) Beta lactam allergy association with surgical site infections (JPIDS) Effect of Macrolides on mortality in Bacteremic Pneumonia (CID) Association of repeated blood cultures with mortality in adult patients with Gram-Negative Bacilli Bacteremia (OFID) Evaluating predictive value of surgical resected proximal bone margins in Diabetic foot Osteomyelitis with clinical outcomes (OFID) Burden of serious Fungal Infections in India (OFID) Bartonella quintana transmitted by head lice (CID) Balamuthia mandrillaris Granulomatous Amoebic Encephalitis (JPIDS) Detecting Leishmania in dogs (PLOS NTD) Primer on home infusion administration methods (OFID) Biomarkers of infection or sepsis at the bedside (ICM) Implementation roadmap for establishing remote infectious disease specialist support in resource-limited settings (OFID) Perceptions and reality of antimicrobial prescribing during the transition to comfort measures (OFID) Can the future of ID escape the inertial dogma of its past? (OFID Music is by Ronald Jenkees [...] Read more...

TWiV 973: Crouching virus, hidden triggers with Felicia GoodrumJanuary 8, 2023Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Felicia Goodrum Click arrow to playDownload TWiV 973 (57 MB .mp3, 95 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:22•The loss of binary (Curr Clin Micro Rep) 10:55•Virology in Peril (mBio) 49:28•Letters read on TWiV 973 1:02:02•Timestamps by Jolene. Thanks! Weekly Picks 1:33:37 Brianne – “Leukocyte” immunology video parodyAlan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subjectVincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car) Listener Picks Karen – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of DiseaseKevin – James Hoffmann and Bald and Bankrupt Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 972: Clinical update with Dr. Daniel GriffinJanuary 7, 2023In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Click arrow to playDownload TWiV 972 (31 MB .mp3, 52 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) 3:07 Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) 6:56 Antibody evasion properties of BQ and XBB subvariants (Cell) 11:25 Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) 18:02 Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) 19:46 Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) 21:18 Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) 24:34 SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) 29:41 Long-term cardiovascular outcomes of COVID-19 (Nature) 33:40 Heart-disease risk soars after COVID (Nature) 34:31 Contribute to our MicrobeTV fundraiser at PWB 35:20 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 972 36:12 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiN 36: Unbearable neurologistsJanuary 3, 2023TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Click arrow to playDownload TWiN 036 (35 MB .mp3, 58 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Letters read on TWiN 36 3:27 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv [...] Read more...

TWiV 971: Another year is viralJanuary 1, 2023In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 971 (57 MB .mp3, 95 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Our favorite 2022 virology stories:•Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) 20:20•Dickson: Interviews with Paul Offit and Andy Slavitt 27:46•Rich: TWiV 948: Breathless with David Quammen 31:39•Kathy: TWiV 915: Mouse mouth to mouse mom 33:52, 1:00:10•Brianne: Spillovers (TWiV 923 and 876) 38:42•Vincent: Giant viruses (TWiV 873, 906, 968) 41:50•Dickson: TWiV 960 – Getting Funky with Dan Wilson 48:17•Rich: TWiV 927: Merchlinsky vs monkeypox 56:50•Kathy: TWiV 958: Pass the RNA and have some venison pi 1:00:23•Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm 1:06:40•Twiverse 1:14:09•Letters read on TWiV 971 1:22:07•Timestamps by Jolene. Thanks! Weekly Picks 1:37:21 Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: DesafinadoBrianne – A Full Circle Rainbow over NorwayKathy – Frozen soap bubblesRich – It’s Turtles All the Way Down in the Fossil Record by Asher ElbeinVincent – Vincent’s Top Ten Music Listener Picks Charles – Wayne Bergeron and Vince DiMartino MacArthur Park Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 970: Clinical update with Dr. Daniel GriffinDecember 31, 2022In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up. Click arrow to playDownload TWiV 970 (31 MB .mp3, 52 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Modeling the adjustment of COVID-19 response and exit in China (Nature) 5:49 Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ) 10:02 N95 respirator failure caused by an overlying face mask (ICHE) 15:12 Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID) 16:13 Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID) 18:55 Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell) 21:21 VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM) 25:03 Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP) 28:35 Molnupiravir as early treatment for adults with COVID-19 (The Lancet) 31:25 Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv) 33:44 FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche) 35:41 Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals) 36:45 Paxlovid patient eligbiliity screening checklist (FDA) Persistent post–COVID-19 smell loss association (Science) 37:46 Epidemiology of long COVID in US adults (CID) 39:41 Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID) 40:55 Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv) 41:26 Contribute to our MicrobeTV fundraiser at PWB 44:52 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 970 45:27 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiM 278: Bacteria sing the bluesDecember 29, 2022TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Right click to download TWiM #278 (36 MB .mp3, 59 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Gut microbiota and depressive symptoms one and two (Nat Commun ) Microbiome influences depression (Phys.org) Gut bacteria and depression (Med Press) Mice behaving badly (TWiM 131) Gut microbiome in ASD (Front Cell Inf Micro) Transferring the blues (J Psych Res) Nucleotides as adjuvants to antibiotics (mBio) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv [...] Read more...

TWiV 969: Carl Zimmer on COVID-19December 28, 2022Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society. Host: Vincent Racaniello Guest: Carl Zimmer Click arrow to playDownload TWiV 969 (29 MB .mp3, 48 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

Infectious Disease Puscast #18December 27, 2022On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 018 (22 MB .mp3, 37 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Human Rabies in Texas, 2021 (CDC) Human rabies despite post-exposure prophylaxis (The Lancet) The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet) An update on eukaryotic viruses revived from ancient permafrost (bioRx) Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM) Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID) Salmonella enteritidis cardiovascular implantable electronic device infection (OFID) Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID) Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID) Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID) Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID) Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID) Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID) Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID) Factors contributing to delayed academic advancement of women in infectious diseases (OFID) Characterization of problematic alcohol use among physicians (JAMA) Alpha-gal syndrome in the ID clinic (OFID) Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet) Music is by Ronald Jenkees [...] Read more...

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