TWiV 664: TWiV is for the dogs
- On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. post
TWiV 663: The joy of vax
- Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. post
TWiM 225: Lag phase is no slouch
- The TWiM team explores how delivery of an enzyme into competitor cells leads to synthesis of (p)ppApp, depletion of ATP, deregulation of metabolic pathways, and cell death, and a refinement of our typical view of bacterial lag phase as a period of nonreplication. post
TWiV 662: Principals of Principles, Fifth Edition
- The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. post
TWiV 661: SWAG with Ralph Baric
- Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. post
TWiP 187: Granny's granuloma
- Dickson, Daniel and Vincent solve the case of the Middle Aged Woman with Loss of Vision in One Eye, and discuss the role of heme oxygenase in the various protozoan infections. post
TWiM 224: One hundred million year old bacteria
- The TWiM team reveals the genetic mysteries of the Dead Sea Scrolls from sequencing of DNA, and 100 million year old living bacteria recovered from marine sediments. post
TWiEVO 59: The hypothesis giving tree
- Nels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins. post
Immune 34: Coronavirus cross-reacting T cells
- Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. post
TWiM 223: The smell of soil
- The TWiMmers explore detection of SARS-CoV-2 on surfaces in an ophthalmology examination room, the ability of stressed populations of Yersinia bacteria to survive antimicrobial treatment within host tissues, and how volatile organic chemicals produced by soil microbes attract arthropods which in turn disperse bacterial spores. post
TWiEVO 58: Not all coronaviruses ACE2 the test
- Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus. post
TWiN 9: COVID-19 neurology with Genna Waldman
- Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. post
TWiP 186: Not rationing rationality
- Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis. post
TWiM 222: Biosensors in bacteria
- Mark Martin joins TWiM to describe nano-sized parasitic bacteria that inhabit humans, and the construction of whole-cell biosensors for detecting arsenic in drinking water. post
Immune 33: COVID-19 immunotypes
- Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. post
TWiN 8: Replacing lost neurons
- TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. post
TWiP 185: Latrinalia
- Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite. post
TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms
- Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain. post
TWiN 7: Stress, the good, bad and beautiful
- The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. post
TWiP 184: The hunter gets captured by the game
- Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria. post
Immune 32: Immunology of COVID-19, part four
- Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. post
TWiEVO 56: Revising the drafts of coronavirus evolution
- Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir. post
TWiN 6: Neural control of sexual behavior
- Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. post
Immune 31: Immunology of COVID-19, part three
- Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. post
Urban Agriculture 29: Gotham Greens
- Dickson travels to indoor farm Gotham Greens in Brooklyn, New York to speak with Co-founder and CEO Viraj Puri. post
Buckyball viruses
- How to build several types of virus particles using the small, powerful magnets called Buckyballs. post
Urban Agriculture 28: The Vertical Farm Institute
- Daniel joins Dickson and Vincent to talk about the Vertical Farm Institute, which provides advice and planning on the design and construction of indoor farms. post
Urban Agriculture 27: The Next Big Things
- Dickson provides an updates on progress towards establishing long-term, sustainable, local, safe food systems based on indoor farming. post
Zika in the guys
- In this episode of Virus Watch, we explore the finding that Zika virus infects the testis of mice, causing damage to the organ, reduced sperm production, and less fertility. The important question: does the same happen in humans? post
Urban Agriculture 26: Green Sense Farms
- Dickson and Vincent speak with Robert Colangelo, founding farmer and CEO of Green Sense Farms, the world's largest commercial indoor vertical farm. post
Cancer Killing Viruses
- Guest host Lynda Coughlan reviews how oncolytic viruses, which specifically kill tumor cells, are designed and how they work. post
Polio in Nigeria
- Polio returns to Nigeria after two years - but it turns out it had never gone away. post