The Latest Podcasts in the Microbe.TV Network

TWiV 981: Tastes like chikungunyaFebruary 5, 2023TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to playDownload TWiV 979 (75 MB .mp3, 124 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf)•Register for ASV 2023•MicrobeTV Discord Server•NSABB proposed oversight framework (pdf)•Stricter US guidelines for research (Nature)•Information on NSABB (NIH)•Consumption of viruses by protists (PNAS)•Letters read on TWiV 981•Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues.Kathy – Measles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al.Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo)Alan – Mt. Washington Observatory webcamVincent – Ask the Experts Listener Picks Roberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiP 213: One deadly snail with Jessie Stone, MDFebruary 4, 2023Jessie Stone joins TWiP to solve the case of the Boy With a Swollen Belly, and discusses Soft Power Health, a clinic that she founded in Uganda to provide healthcare for people in need. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Jessie Stone Click arrow to playDownload TWiP #213 (49 MB .mp3, 81 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode •Soft Power Health•Letters read on TWiP 213 Become a patron of TWiP Case Study for TWiP 213 A 49 y.o. German male is seen with significant gross hematuria. He reports no travel outside Europe but does report that he visited France twice, 7 years before and 1 year before. He reports swimming in the Solenzara River in the southeastern part of the island, near a busy campsite. He might have gone into the Gravona River in western Corsica near Ajaccio, at a turtle park and near a campsite, and at the Tavignano River. The patient also reported swimming in the Restonica River. He reports never swimming in the Cavu River and using GPS data from his smartphone and camera, he reconstructed his bathing sites precisely and this history was confirmed. Exam was unremarkable. Complete blood count was unremarkable and did not show eosinophilia. This complaint triggered cystoscopy and biopsies that were sent for histological analysis. These findings triggered referral to the Tropical Medicine department at LMU Hospital Munich. Now in the next episode we will have a guest to discuss this case as well as tell us a bit about themselves. I am hoping people will tell us what they think this might be but then perhaps do a bit of research and go into a little more detail. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees [...] Read more...

TWiV 980: Clinical update with Dr. Daniel GriffinFebruary 4, 2023In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2, effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods. Click arrow to playDownload TWiV 980 (24 MB .mp3, 40 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prevalence and clinical outcomes of RSV vs influenza in adults (CID) Reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID) Assessment of COVID-19 as the underlying cause of death among children and young people (JAMA) Information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 infection (CDC) Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) Effectiveness of bivalent boosters against severe Omicron infection (NEJM) Covid vaccines and playing the long game (NEJM) Efficacy and safety of antimicrobial stewardship prospective audit and feedback in COVID-19 patients (The Lancet) Severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infection (CID) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 980 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiM 280: They forgot to divideFebruary 3, 2023TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase effector. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Right click to download TWiM #280 (36 MB .mp3, 59 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: •Magnesium modulates cell division frequency (J Bacteriol)•A. baumannii kills fungi (mBio) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv [...] Read more...

TWiV Special: One COVID vaccine for them all with Paul OffitFebruary 3, 2023Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Click arrow to playDownload TWiV Special (23 MB .mp3, 39 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA briefing document (pdf) Effectiveness of bivalent booster against severe infection (NEJM) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiEVO 86: Pulling out the stops in genetic code evolutionFebruary 2, 2023Nels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop. Hosts: Nels Elde and Vincent Racaniello Click arrow to playDownload TWiEVO 86 (55 MB .mp3, 97 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode •Join the MicrobeTV Discord server•Novel stop codon reassignment mechanisms (Nature) Science Picks Nels – Protein Synthesis: An epic on the cellular level Vincent – Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes discussed on TWiM 277 Music on TWiEVO is performed by Trampled by TurtlesSend your evolution questions and comments to twievo@microbe.tv [...] Read more...

TWiV 979: Flushing out the viroidsJanuary 29, 2023TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems. . Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to playDownload TWiV 979 (63 MB .mp3, 105 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 1:58•Register for ASV 2023 2:45•MicrobeTV Discord Server 4:53•Nick Muzyczka passes 1:31:39•Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) 10:51•Vast world of viroid-like RNAs (Cell) 29:35•Letters read on TWiV 979 1:12:54•Timestamps by Jolene. Thanks! Weekly Picks 1:30:24 Kathy – 3B new Milky Way objects, Green cometRich – Virology under the Microscope—a Call for Rational DiscourseAlan – Indie story-driven games series #3: Valiant Hearts: The Great WarVincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf Listener Picks Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article) Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 978: Clinical update with Dr. Daniel GriffinJanuary 28, 2023In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Click arrow to playDownload TWiV 978 (24 MB .mp3, 39 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) 1:35 Preprint review should form part of PhD programmes and postdoc training (Nature) 3:16 Early and increased Influenza activity among children (CDC) 4:27 COVID-19 vaccines versus pediatric hospitalization (Cell) 8:10 SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) 10:31 Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) 12:47 Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) 14:21 Effects of Dexamethasone use among patients with COVID-19 (IJID) 24:42 Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ) 26:04 Contribute to our MicrobeTV fundraiser at PWB 28:52 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 978 29:25 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

Infectious Disease Puscast #20January 25, 2023On episode #20 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/4/23 – 1/17/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 020 (17 MB .mp3, 29 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Neuroinvasive West Nile infection in solid organ transplant recipients (TID) Clinical markers of post-Chikungunya chronic inflammatory joint disease (PLOSNTD) Cholera outbreak in Haiti (CDC) Legionella bononiensis isolated from a hotel water in Nothern Italy (MS) Contemporary pharmacotherapies for nontuberculosis mycobacterial infections (IDT) Defining the optimal duration of therapy for hospitalized patients with UTIs and Bacteremia (CID) Fidaxomicin to prevent recurrent Clostridioides difficile (JAC) Evaluating predictive value of resected proximal bone margins in Diabetic Foot Osteomyelitis(OFID) Postoperative inflammation and fever after elective aortic valve and aortic root replacement (OFID) Fungal nomenclature: managing change is the name of the game (OFID) Clinical microbiology laboratories should use nomenclature based on current taxonomy (JCM) Race and ethnicity: risk factors for fungal infections (PLOS) Mosquito net use in early childhood and survival to adulthood in Tanzania (NEJM) Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand (The Lancet) Music is by Ronald Jenkees [...] Read more...

Immune 64: A tangled web of wiresJanuary 23, 2023Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Click arrow to playDownload Immune 64 (66 MB .mp3, 110 min)Subscribe (free): Apple Podcasts, Google Podcasts. RSS, emailBecome a patron of Immune! Links for this episode MicrobeTV Discord Server Tangled web of wires (Nature) 2:07 Path to group A Streptococcus vaccines (Clin Inf Dis) 18:39 Immune end-types predictive of vaccine responses (Nat Immunol) 25:12 IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol) 35:14 Very bad B cells (Immunity) 44:11 Two epitope Streptococcus monoclonal (EMBO Mol Med) 59:33 Predictor of vaccine-induced antibody responses (Nat Immunol) 1:08:44 Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med) 1:18:25 Neutrophilic inflammation and RSV infection (Science) 1:23:24 Commensals avoiding recognition (Sci Immunol) 1:30:17 Continuous germinal center invasion and immune response diversity (Cell) 1:35:22 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen MedicalSend your immunology questions and comments to immune@microbe.tv [...] Read more...

TWiN 37: Microglia at the crossroadsJanuary 23, 2023TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Click arrow to playDownload TWiN 036 (45 MB .mp3, 75 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Microglia states and nomenclature (Nature) 4:12 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv [...] Read more...

TWiV 977: Ageing is infectiousJanuary 22, 2023TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Click arrow to playDownload TWiV 977 (63 MB .mp3, 105 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:27•Register for ASV 2023 3:10•MicrobeTV Discord Server 4:15•Persistence of SARS-CoV-2 (Nature) 6:13•Endogenous retroviruses and senescence (Cell) 29:55•Timestamps by Jolene. Thanks! Weekly Picks 1:26:32 Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s TuneAngela – World’s Longest AnimalBrianne – Green Comet to Pass By Earth for first time in 50,000 yearsAlan – Indie games series: Golf Club WastelandVincent – Bivalent Covid-19 Vaccines — A Cautionary Tale Listener Picks Lisa – The River and the Wall Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 976: Clinical update with Dr. Daniel GriffinJanuary 21, 2023In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. Click arrow to playDownload TWiV 976 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China records almost 60,000 COVID-related deaths (SCMP) 6:05 Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature) 9:46 Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA) 15:18 Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID) 19:51 Long COVID outcomes at one year after mild infection (BMJ) 24:38 Major findings, mechanisms and recommendations for Long COVID (Nature) 25:30 Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI) 27:36 Effect of using a structured pacing protocol (JMV) 30:00 Contribute to our MicrobeTV fundraiser at PWB 33:07 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 976 33:30 Don’t crush Paxlovid (pdf) 33:38 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiM 279: A road map for successful phage therapyJanuary 19, 2023TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Right click to download TWiM #279 (36 MB .mp3, 59 minutes) Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Phage therapy against M. abscessus lung infection (Cell) Encapsulation of the septal cell wall protects S. pneumoniae from host defenses (PLoS Path) Letters read on TWiM 279 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv [...] Read more...

TWiV 975: Crossing the Ts with Daniela WeiskopfJanuary 15, 2023Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Daniela Weiskopf Click arrow to playDownload TWiV 975 (58 MB .mp3, 98 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:47•Register for ASV 2023 3:36•Cross reactive T cells to SARS-CoV-2 (Science) 25:50•SARS-CoV-2 exposure history and T cell response (Cell Rep Med) 42:13•Spike T cells cross- recognize Omicron (Nature) 45:05•Ancestral SARS-CoV-2 T cells recognize Omicron (Nature)•NVX-CoV2373 induces T cell responses (J Clin Inves) 47:23•Letters read on TWiV 975 1:09:34•Timestamps by Jolene. Thanks! Weekly Picks 1:26:29 Brianne – Video of viral attachment (based on this article)Alan – Starting a series of innovative indie video games. First up: The Longing.Vincent – The Amy Papers and Calendar for live events Listener Picks Judy – Innate immune evasion strategies of SARS-CoV-2Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 974: Clinical update with Dr. Daniel GriffinJanuary 14, 2023In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection. Click arrow to playDownload TWiV 974 (28 MB .mp3, 47 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 more widespread in animals than thought (Nat Geo) 12:34 Increasing ventilation reduces airborne transmission in schools (Frontiers) 14:31 Carbon dioxide monitoring to assess ventilation at a NID conference (CID) 15:58 Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet) 18:39 Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet) 23:49 Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ) 29:29 Contribute to our MicrobeTV fundraiser at PWB 35:28 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 974 36:31 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

Infectious Disease Puscast #19January 10, 2023On episode #19 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/22/22 – 1/3/23. Hosts: Daniel Griffin and Sara Dong Click arrow to playDownload Puscast 019 (25 MB .mp3, 42 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Burden of postinfectious symptoms after Acute Dengue (EID) Maribavir for CMV treatment in the real world (OFID) 24-Week all-oral regimen for Rifampin-Resistant Tuberculosis (NEJM) Beta lactam allergy association with surgical site infections (JPIDS) Effect of Macrolides on mortality in Bacteremic Pneumonia (CID) Association of repeated blood cultures with mortality in adult patients with Gram-Negative Bacilli Bacteremia (OFID) Evaluating predictive value of surgical resected proximal bone margins in Diabetic foot Osteomyelitis with clinical outcomes (OFID) Burden of serious Fungal Infections in India (OFID) Bartonella quintana transmitted by head lice (CID) Balamuthia mandrillaris Granulomatous Amoebic Encephalitis (JPIDS) Detecting Leishmania in dogs (PLOS NTD) Primer on home infusion administration methods (OFID) Biomarkers of infection or sepsis at the bedside (ICM) Implementation roadmap for establishing remote infectious disease specialist support in resource-limited settings (OFID) Perceptions and reality of antimicrobial prescribing during the transition to comfort measures (OFID) Can the future of ID escape the inertial dogma of its past? (OFID Music is by Ronald Jenkees [...] Read more...

TWiV 973: Crouching virus, hidden triggers with Felicia GoodrumJanuary 8, 2023Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Felicia Goodrum Click arrow to playDownload TWiV 973 (57 MB .mp3, 95 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) 2:22•The loss of binary (Curr Clin Micro Rep) 10:55•Virology in Peril (mBio) 49:28•Letters read on TWiV 973 1:02:02•Timestamps by Jolene. Thanks! Weekly Picks 1:33:37 Brianne – “Leukocyte” immunology video parodyAlan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subjectVincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car) Listener Picks Karen – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of DiseaseKevin – James Hoffmann and Bald and Bankrupt Intro music is by Ronald JenkeesSend your virology questions and comments to twiv@microbe.tv [...] Read more...

TWiV 972: Clinical update with Dr. Daniel GriffinJanuary 7, 2023In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Click arrow to playDownload TWiV 972 (31 MB .mp3, 52 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) 3:07 Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) 6:56 Antibody evasion properties of BQ and XBB subvariants (Cell) 11:25 Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) 18:02 Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) 19:46 Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) 21:18 Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) 24:34 SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) 29:41 Long-term cardiovascular outcomes of COVID-19 (Nature) 33:40 Heart-disease risk soars after COVID (Nature) 34:31 Contribute to our MicrobeTV fundraiser at PWB 35:20 Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 972 36:12 Timestamps by Jolene. Thanks! Intro music is by Ronald JenkeesSend your questions for Dr. Griffin to daniel@microbe.tv [...] Read more...

TWiN 36: Unbearable neurologistsJanuary 3, 2023TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Click arrow to playDownload TWiN 036 (35 MB .mp3, 58 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Letters read on TWiN 36 3:27 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv [...] Read more...

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