TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 925 (61 MB .mp3, 102 min)
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Weekly Picks 1:23:27

BrianneEveryone Loses on Jeopardy Eventually
Kathy – Climate spiral  followed by Carl Sagan
Rich Most Popular Desktop Browsers 1993 – 2022
Alan – I Am Promise
VincentPolio in New York

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.

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Download TWiV 924 (28 MB .mp3, 46 min)
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Intro music is by Ronald Jenkees

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From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.

Hosts: Vincent Racaniello and Brianne Barker

Guests: Vincent Munster and Raina Plowright

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Download TWiV 923 (39 MB .mp3, 65 min)
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Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses monkeypox virus infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.

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Download TWiV 922 (25 MB .mp3, 42 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Pamela Bjorkman and Andy Mehle

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Download TWiV 920 (61 MB .mp3, 102 min)
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Intro music is by Ronald Jenkees

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In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.

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Download TWiV 921 (24 MB .mp3, 41 min)
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Intro music is by Ronald Jenkees

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TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 919 (61 MB .mp3, 102 min)
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Weekly Picks 1:20:34

BrianneRedactle
KathyKirigami paper replacing plastic bubble wrap
RichFirst Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent Spotted lanternfly

Listener Picks

AnnNASA Engineer Who Made the James Webb Space Telescope Work
SonrisaAloft – the pleasures and risks of flying

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.

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Download TWiV 918 (24 MB .mp3, 41 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Paul Offit

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Download TWiV 917 (70 MB .mp3, 117 min)
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Weekly Picks 1:20:41

Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
KathySolargraphic analemmas
Rich – Windy (desktop; app)
Vincent Why monkeypox is mostly hitting men who have sex with men

Listener Picks

MarkHand Wash Dance – NHK WORLD-JAPAN

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection.

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Download TWiV 916 (22 MB .mp3, 37 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv