TWiV 902: Autoantibodies drive severe COVID-19

TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:48:18

Dickson – How to grow food on the moon
Brianne – APod May 16: Milky Way over French Alp Hoodoos
Kathy – Covid Nationwide data visualization
Rich – NIH All of Us Research Program
Vincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?

Listener Pick

Lisa – E.H. Danner Museum of Telephony

Intro music is by Ronald Jenkees

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TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin

In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 900: Burning down the mouse

TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:17:45

Brianne – The Milky Way’s Black Hole Comes to Light
Kathy – River dolphins playing with anaconda
Rich – Smallpox vaccination techniques; from knives and forks to needles and pins
Alan – Vacuum Tubes: a Modern Aladdin’s Lamp
Vincent – Books by Pamela Jane

Intro music is by Ronald Jenkees

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TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin

In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 898: Immunity is skin deep

TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:27:50

Brianne – Bacteria and Me Coloring Book
Kathy – Smarter 3D printing
Rich – Big Ben Restoring the Worlds Most Famous Clock 2021
Vincent – Scientific review articles as antivaccine disinformation

Listener Pick

Suellen – Your Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)

Intro music is by Ronald Jenkees

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TWiV 897: COVID-19 clinical update #113 with Dr. Daniel Griffin

In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 896: Memory B cells, the way we were

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks 1:32:48

Dickson – Toots Thilelemans
Amy – Largest comet ever identified
Vincent – Scientific review articles as antivaccine disinformation

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin

In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 894: Dinner with the TMPRSS family

TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:25:29

Brianne – Apple AirTag
Kathy – Dental art/sculpture/mobile/chandelier
Alan – Vintage Radio and Communications Museum of Connecticut
Vincent – For the Love of Enzymes by Arthur Kornberg

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 893: Yellow fever virus escapes antibodies

Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera

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Download TWiV 893 (65 MB .mp3, 108 min)
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Weekly Picks 1:13:29

Dickson – Earth Day and Earth Day History
Brianne – XKCD: Family Reunion
Vincent – Tokaido: A Journey (DVD)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

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