TWiV 1013: Bird flu around the world

TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli

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Weekly Picks 1:29:31

Angela – May’s best science images – Nature
Kathy – Historical reasons for resistance to recognizing airborne transmission
Rich – Scan of Titanic reveals wreck as never seen before – BBC News
Alan – Science Education in an Age of Misinformation
Vincent – Equity, Diversity and Inclusion: When communication all changed

Intro music is by Ronald Jenkees

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TWiV 1012: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients.

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  • Potential for recurrent Mpox outbreaks among men who have sex with men (CDC) 3:31
  • Association between SARS-CoV-2 variants and frequency of acute symptoms (OFID) 8:19
  • Key correlates for household transmission of SARS-CoV-2 (OFID) 10:54
  • PAXLOVID receiving FDA approval for patients at high risk of severe COVID-19 (Pfizer) 12:35
  • Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients with COVID-19 (The Lancet) 14:44
  • Development of a definition of postacute sequelae of SARS-CoV-2 (JAMA) 17:46
  • COVID-19 and risk for mental disorders among adults in Denmark (JAMA) 25:40
  • Risk of new post-COVID mental disorders higher only in older patients (CIDRAP) 25:50
  • Contribute to our FIMRC fundraiser at PWB 29:21
  • Letters read on TWiV 1012 29:54
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1011: Aquatic viruses

Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities.

Host: Vincent Racaniello

Guests: Frank Aylward and Jed Fuhrman

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Intro music is by Ronald Jenkees

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TWiV 1010: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1009: Nidovirus on the water

Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.

Host: Vincent Racaniello

Guests: Kanta Subbarao and Maria von Kerkhove

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Intro music is by Ronald Jenkees

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TWiV 1008: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1007: Fragile DNA, viruses, cancer

TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

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Weekly Picks 1:19:21

Angela – Night Science
Kathy – Kermit, Jim Henson, Rainbow Connection
Rich – Alexander Skarsgård Explains the Answer to Everything
Vincent – Beyond the Noise with Dr. Paul Offit

Intro music is by Ronald Jenkees

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TWiV 1006: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19.

Click arrow to play Download TWiV 1006 (26 MB .mp3, 43 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1005: COVID T vax and a virus from the blue

TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:26:42

Brianne – Immune #67: Can T cells Live Forever?
Kathy – Hazel Scott, Trinidad Jazz star
Alan – The Last Navigator, Steve Thomas
Vincent – Nasal Spray Covid Vaccines: Hope or Hype?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1004: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.

Click arrow to play Download TWiV 1004 (32 MB .mp3, 53 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

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