A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.

Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld

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Weekly Picks 1:37:48

AmyA relic from the Jurassic era
AlanWorld of Wonders, by Aimee Nezhukumatathil
VincentTom Buck’s YouTube Channel

Listener Pick

VictorVaccines: A measured response

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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38 MB .mp3, 39 min)
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Intro music is by Ronald Jenkees

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On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:38:36

Brianne Pandemics for Babies, Germ Theory for Babies, and Vaccines for Babies
KathyPlaying with Time
VincentA Top Virologist in China, at Center of a Pandemic Storm, Speaks Out

Intro music is by Ronald Jenkees

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TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Weekly Picks 1:29:12

Dickson Hotel Magdalena
Brianne Antibody Song by Raven the Science Maven
AlanHow to play Magic: the Gathering
VincentSteve Gibson’s rant on Security Now

Listener Pick

DavidCoronavirus set to music

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: David Fajgenbaum

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Weekly Picks 1:19:28

Brianne How Giraffes Beat High Blood Pressure
KathyOrangutan optical illusion
Vincent – Two quotes from Chasing My Cure by David Fajgenbaum

John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.

David: Never stop questioning and always follow the data.

Listener Picks

GregStewart Lee on Loch Ness monster

Intro music is by Ronald Jenkees

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TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks 1:33:28

Dickson NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede
Brianne Send in the Bugs. The Michelangelos Need Cleaning.
RichAll landers and rovers on Mars  animated in video with human scale
AlanWeird case cluster reported in MMWR 40 years ago; update on disease
VincentVirus isolates, strains, variants – what are they?

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Weekly Picks 1:31:33

Kathy Flat pasta that turns into shapes here and here
RichAd Fontes Media Bias Chart (wiki)
VincentMartin Beck police mysteries

Listener Picks

GregStewart Lee on Loch Ness monster

Intro music is by Ronald Jenkees

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Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Robert Garry

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Weekly Picks 48:43, 1:36:35

Dickson 143 Optical Illusions and Visual Phenomena
Brianne The Arcane Research that Prepared Us for COVID-19
RichHidden Brain podcast
AlanA scientific theory of gist communication
VincentDivisive COVID ‘lab leak’ debate prompts dire warnings from researchers

Listener Picks

JonModerna Science Day

Intro music is by Ronald Jenkees

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