Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Weekly Picks

DicksonNASA ingenuity helicopter ride
BrianneVaccine Efficacy Animation
KathyAirglow over the Azores
VincentGisaid

Intro music is by Ronald Jenkees

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Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

Guest: Nadine Lamberski

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Download TWiV 745 (65 MB .mp3, 108 min)
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Weekly Picks 1:37:12

BrianneThe Dream Vaccine
AlanTaking vaccines to Smith Island
KathyDaily Overviews Subscribe Tulips
VincentNextstrain

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:44:48

DicksonA tiny particle’s wobble could upend the laws of physics
RichCOVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy
AmyVaccine Anthems
VincentDarkNet Diaries Ep. 86

Listener Picks

SteveCover Your Freakin’ Face

Intro music is by Ronald Jenkees

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TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Download TWiV 742 (65 MB .mp3, 108 min)
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Weekly Picks 1:33:41

BrianneCOVID-19: a disaster five years in the making
AlanThe Tyranny of Merit
RichRacism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
VincentTrudy Rey’s YouTube Channel

Listener Picks

JeffRebecca Lee Smith on Left Right and Center
RyanPerfect Strangers (clip)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 741 (26 MB .mp3, 43 min)
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Intro music is by Ronald Jenkees

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The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:20:38

DicksonLet us now praise tiny ants
BrianneSmall-school science
RichSmallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

Intro music is by Ronald Jenkees

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Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Arturo Casadevall

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Download TWiV 739 (68 MB .mp3, 113 min)
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Weekly Picks 1:42:35

BrianneThe Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan7 Billion Humans
Rich15 Fascinating Animal X-Rays From the Oregon Zoo
VincentRespiratory pathogen trends

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #56, Daniel Griffin notes increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 738 (21 MB .mp3, 35 min)
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Intro music is by Ronald Jenkees

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John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: John Dennehy, Davida Smyth, and Monica Trujillo

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Weekly Picks 1:45:00

Dickson250,000 Dominoes
BrianneUsing RT-PCR in COVID-19 Testing
RichBeaded Lacewings Can Take Down Six Termites With A Single Fart
KathyTracking the COVID code
VincentAdministering vaccines to adults

Intro music is by Ronald Jenkees

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