TWiV 687: Peter Hotez sticks to the vax

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Peter Hotez

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Weekly Science Picks 2:06:06

Dickson – The World’s First Energy-Positive Hotel to Open in Norway
Brianne – The Food Lab: Better Home Cooking Through Science
Alan – ACIP’s ethical principles for COVID-19 vaccine allocation
Rich – The Mandolorian
Vincent – T. rex and the Crater of Doom by Walter Alvarez

Intro music is by Ronald Jenkees

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TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV 685: Pandemicky

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:40:35

Brianne – Types of Scientists Coloring Book
Kathy – South Pole video
Rich – Steve Jobs by Walter Isaacson
Vincent – Screenology (I interviewed Deb Sklut here)

Listener Pick

Mona – Ad5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

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TWiV 684: Persistence of SARS-CoV-2 immune memory

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Shane Crotty

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Weekly Science Picks 2:44:51

Dickson – Benoit Mandlebrot’s 96 birthday
Brianne – #BlackinImmunoWeek
Rich – GoISSWatch ISS Tracking; Spot The Station (NASA)
Vincent – Microbes Rule

Listener Pick

Agda – Sandwalk

Intro music is by Ronald Jenkees

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TWiV 683: Two COVID-19 mRNA vaccines

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:43:25

Brianne – Picture a Scientist
Kathy – Colors of the Moon and Word that hasn’t changed
Rich – NASA YouTube channel
Vincent – Laura Splan science art

Listener Pick

Mona – Ad5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

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TWiV 682: Kate Rubins from the International Space Station

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.

Hosts: Vincent Racaniello and Rich Condit

Guest: Kate Rubins

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Intro music is by Ronald Jenkees

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TWiV 681: Crowley, coats, and cross-reactive antibodies

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Kathleen A. Crowley

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Weekly Science Picks 2:33:04

Dickson – OSIRIS-REx | NASA
Brianne – Virtual Science Museum Tours
Alan – Ring Fit Adventure
Rich – BUGSS Baltimore Underground Science Space
Vincent – Trilobite glassworks

Listener Pick

Gina and Joe – COVID Fan Tutte

Intro music is by Ronald Jenkees

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TWiV 680: Long-term COVID and ME/CFS

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guests: Mady Hornig, Fiona Lowenstein, and David Tuller

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Intro music is by Ronald Jenkees

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TWiV 679: Mink, mutation, and myocytes

Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Amy Rosenfeld

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Weekly Science Picks 2:14:46

Dickson – CNN News
Amy – I voted and Grace for President
Alan – The Story of More by Hope Jahren
Rich – OSIRIS-REx and 101955 Bennu
Vincent – The Vexed Muddler

Intro music is by Ronald Jenkees

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TWiV 678: Fishing for viruses with Nels Elde

Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Nels Elde

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Download TWiV 678 (67 MB .mp3, 111 min)
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Weekly Science Picks 58:37, 1:42:57

Kathy –  Why art is important and Tagging an asteroid
Rich – Vendee Globe
Vincent – PrePubMed

Intro music is by Ronald Jenkees

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