TWiV 995: Viral origin stories

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli

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Download TWiV 995 (74 MB .mp3, 123 min)
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•Register for ASV 2023
•MicrobeTV Discord Server
• More evidence for SARS-CoV-2 spillover (Zenodo)
•Polio cases linked to nOPV2 (Science; GPEI statement)
•nOPV2 on TWiV 756
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe)
•Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology)
•HBV shifts from naked to enveloped (Nat Comm)
•Letters read on TWiV 995
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World
Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

Gary – Tony Fauci on PBS
Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 994: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 993: COVID-19 drives autoimmunity

TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.

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•Register for ASV 2023 2:20
•MicrobeTV Discord Server
•Janet Sinsheimer on TWiV 653 5:05
•Clearance of chronic poliovirus infection by remdesivir (Front Immunol) 7:47
•Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) 33:08
•Letters read on TWiV 993 1:07:23
•Timestamps by Jolene. Thanks!

Weekly Picks 1:35:41

Brianne – Xkcd: Lymphocytes
Kathy – A brief history of Parafilm with video
Alan – Mapping and exploring the USS Monitor wreck
Vincent – Skype a Scientist

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 992: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment.

Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 991: The cancer mRNA shot

On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice.

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•Register for ASV 2023 2:56
•MicrobeTV Discord Server
•1918 influenza virus not lethal in nonhuman primates (J Virol) 10:33
•mRNA vaccines control HPV-associated tumors (Sci Trans Med) 40:19
•Letters read on TWiV 991 1:16:52
•Timestamps by Jolene. Thanks!

Weekly Picks 1:42:39

Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington
Rich – Protein synthesis: an epic on the cellular level
Alan – Thomas Was Alone
Vincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out

Listener Pick

Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 990: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19.

Click arrow to play Download TWiV 990 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 989: Antibody cross-reactivity is metal

TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses.

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•Register for ASV 2023 2:11
•MicrobeTV Discord Server
•Paul Berg obituary 3:44
•Spike mRNA in blood (J Path Micro Imm) 12:21
•Spike mRNA in blood (Biomedicine) 27:37
•Cross-protective mAbs against respiratory viruses (Nat Comm) 31:21
•RSV prefusion F protein vaccine in older adults (NEJM) 1:06:31
•Ad26.RSV.preF–RSV preF protein vaccine (NEJM) 1:09:16
•Letters read on TWiV 989 1:17:33
•Timestamps by Jolene. Thanks!

Weekly Picks 1:32:08

Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet).
Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic
Kathy – “That’s What They Say” podcast about pronunciation of “primer.”
Rich – Slow motion art:  1 and 2
Vincent – Grammarly

Listener Pick

Charles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 988: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.

Click arrow to play Download TWiV 988 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 987: Convalescing with Casadevall

Arturo Casadevall returns to TWiV to explain the use of convalescent plasma to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Arturo Casadevall

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Download TWiV 987 (70 MB .mp3, 116 min)
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Weekly Picks 1:40:30

Rich – Flammarion engraving
Alan – What Remains of Edith Finch
Vincent – The CDC’s Long-Covid Deception

Listener Pick

Bill – General Relativity For Babies

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 986: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.

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Download TWiV 986 (26 MB .mp3, 43 min)
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Become a patron of TWiV!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

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