This Week in Virology

TWiV 619: Recombination led to emergence of SARS-CoV-2

May 27, 2020

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Rabadan Laboratory
Understanding Coronavirus (Amazon)
Topological Data Analysis for Genomics and Evolution (Amazon)
Recombination and mutation shaped SARS-CoV-2 (bioRxiv)
Bat CoV with cleavage site insertion (Curr Biol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 618: Nipah virus at 20

May 26, 2020

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Download TWiV 615 (35 MB .mp3, 58 min)
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Intro music is by Ronald Jenkees.

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TWiV 617: Coronavirus Times

May 24, 2020

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 617 (91 MB .mp3, 152 min)
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Playing tennis safely (USTA) 48:03
Scientists denounce end to CoV grant (NY Times) 50:17
ASMBMB denounces end to CoV grant (pdf) 51:01
For TETRIS, turn to Paterson NJ (NY Times) 53:49
NJ Dept of Health (image credit) 55:31
Differential effects of intervention timing (medRxiv and NY Times) 58:50
Texas to stop combining test results (Statesman) 1:02:43
How could CDC make that mistake? (Atlantic) 1:03:22
The Pandemic and Information Network (Columbia Journ Rev) 1:12:21
Helmet and tent (Science) 1:15:24
New song, old melody (Cell Host Microbe) 1:17:43
Letters read on TWiV 617 34:21, 53:27, 1:24:43
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 616: Singing about coronavirus

May 21, 2020

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna’s mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 616 (62 MB .mp3, 103 min)
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Intro music is by Ronald Jenkees.

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TWiV 615: Peter Daszak of EcoHealth Alliance

May 19, 2020

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Download TWiV 615 (22 MB .mp3, 36 min)
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Intro music is by Ronald Jenkees.

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TWiV 614: COVID Tetris – Test, trace, isolate

May 17, 2020

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 614 (100 MB .mp3, 167 min)
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Triple therapy for COVID-19 (Lancet) 33:47
Virology podcast goes viral (Thalia Gigerenzer) 45:22
Paul Stays Home (pdf) 48:30
Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) 51:01
Mumbai engulfed by CoV (NY Times) 58:13
All must be vaccinated (Stat) 1:00:23
FDA concerns with Abbott test (FDA) 1:03:11
How US lost 6 weeks (BBC) 1:11:26
Letters read on TWiV 614 26:35, 40:21, 1:12:22
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 613: Jenner, vaccines, and COVID-19

May 14, 2020

Vincent, Kathy and Rich explain the Jenner Institute’s SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Download TWiV 613 (63 MB .mp3, 106 min)
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COVID-19 brings out dark side of science (Mother Jones, Wired) 1:34
Jenner Institute COVID-19 vaccine (BioSpace) 11:11
Recombineering (Nucleic Acids Res) 13:48
Vaccines lecture (YouTube) 52:58
ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) 28:28
Chimpanzee adenovirus vector (PLoS One) 33:34
Ad-MERS vaccine protects monkeys (NIH) 28:08
Rapid COVID-19 vaccine development (Science) 43:56
Strategic approach to COVID-19 vaccines (Science) 48:19
NIH decision to stop remdesivir study (Stat) 53:16
80,000 flu deaths this winter (Stat) 55:09
Science and singing (YouTube) 1:16:55
COVID-19 at choir practice (Emerg Inf Dis) 1:22:00
Letters read on TWiV 613 36:56, 55:52
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 612: CEPI, preventing the next pandemic

May 12, 2020

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Download TWiV 612 (87 MB .mp3, 143 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 611: Corona and crowns

May 10, 2020

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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Download TWiV 611 (87 MB .mp3, 143 min)
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OSHA guidance for dentistry 33:16
COVID0-19 challenges for dentistry (J Dent Res) 45:20
COVID-19 and dentistry (Int J Env Res Pub Health)
Mouthrinses for dentistry (J Clin Med) 48:50, 54:08
Disingenuous plandemic documentary (Big Think) 1:29:32
Letters read on TWiV 611: 26:41, 1:12:18, 1:16:50
- Plain language talking points on virus origins 1:17:00, 1:20:40
Image credit
Kiki’s comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 610: Coronavirus FAQ

May 7, 2020

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 610 (60 MB .mp3, 99 min)
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FDA revises statement on antibody tests (FDA) 3:20
Serology-based tests for SARS-CoV-2 (Center for Health Security) 5:32
ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) 14:40
Global COVID-19 CFR (CEBM) 23:27
Debunking transmission mutation: TWiEVO 55 1:36:01
Letters read on TWiV 610 27:58
- Plain language answers to listener questions 1:10:42-1:34:16
- Question 1 – 1:14:55
- Question 2 – 1:28:19
- More on TWiV 611
Image credit
Kiki’s Comments
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 619: Recombination led to emergence of SARS-CoV-2

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TWiV 618: Nipah virus at 20

TWiV 617: Coronavirus Times

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TWiV 616: Singing about coronavirus

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TWiV 615: Peter Daszak of EcoHealth Alliance

TWiV 614: COVID Tetris – Test, trace, isolate

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TWiV 613: Jenner, vaccines, and COVID-19

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TWiV 612: CEPI, preventing the next pandemic

TWiV 611: Corona and crowns

Links for this episode

TWiV 610: Coronavirus FAQ

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