TWiV 1047: Long COVID and avian flu in ferrets

TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks 1:31:20

Dickson – UN Climate Action and California sues oil companies for exacerbating climate change
Brianne – COVID Drugs are a Miracle Cure for Cats
Rich – American Prometheus by Kai Bird and Martin J. Sherwin
Vincent – Free Carl Zimmer writings

Listener Pick

Anne – She wrote to a scientist about her fatigue. It inspired a breakthrough.
Alan – This Tiny Parasitic Wasp Can Drill Through Plastic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1046: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID.

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Download TWiV 1046 (34 MB .mp3, 47 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1045: Less Lassa, CRISPR RNA viruses

TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli

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Weekly Picks 1:25:59

Angela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot (journal article)
Brianne – The story of our universe may be starting to unravel
Rich – Sunlight Changes Unequally All Year Long
Alan – Arm swing asymmetry in overground walking
Vincent – The Farm at the Javits Center

Listener Pick

Asal – Ig Nobel Prizes honor zombie spiders, rock-licking scientists, and a clever commode

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1044: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children <5 years of age, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, safety and immunogenicity of XBB.1.5-containing mRNA vaccines, optimal duration of systemic corticosteroids in COVID-19 treatment, timing and predictors of loss of infectivity among healthcare workers with mild primary and recurrent COVID-19, and effects of famotidine on cognitive and behavioral dysfunctions induced in post-COVID-19 infection.

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Download TWiV 1044 (31 MB .mp3, 43 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1043: Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics.

Host: Vincent Racaniello

Guest: Marion Koopmans

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Download TWiV 1043 (45 MB .mp3, 62 min)
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Intro music is by Ronald Jenkees

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TWiV 1042: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1041: Novel oral polio vaccine? with Raul Andino and Kostya Chumakov

Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis.

Host: Vincent Racaniello

Guests: Raul Andino and Kostya Chumakov

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Download TWiV 1041 (64 MB .mp3, 89 min)
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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1040: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech receive positive CHMP opinion for Omicron XBB.1.5-adapted COVID-19 vaccine in the European Union, clinical antiviral efficacy of Remdesivir in COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, clinical outcomes associated with overestimation of oxygen saturation by pulse oximetry in patients hospitalized with COVID-19, risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination.

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Download TWiV 1040 (19 MB .mp3, 27 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1039: Landmines for phages, a mouthful of redondoviruses

TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey

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Download TWiV 1039 (87 MB .mp3, 121 min)
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Weekly Picks 1:44:56

Dickson – “Cosmic Time Machine” Netflix documentary
Kathy – Antarctican accents
Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites
Jolene – Perspective article on best practices for improving graduate admissions
Vincent – Why Chandrayaan-3 landed near the moon’s south pole — and why everyone else wants to get there too

Listener Picks

Douglas – On Climate Change and (Active) Climate Management
Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1038: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and virological treatment failure, incidence of new-onset hypertension post–COVID-19: comparison with influenza, and post-acute sequelae of COVID-19 at 2 years.

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Download TWiV 1038 (19 MB .mp3, 27 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

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Inside a BSL-4 laboratory

TWiV visits the NEIDL