The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Click arrow to play
Download TWiV 818 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Weekly Picks

Dickson –  John Clease
BrianneAstronomy Picture of the Day: Swirl in the Southern Sky
Kathy – Lise Meitner  Statue is at the Humboldt University
RichGoogle has the cleanest cloud. Now it’s helping other companies go green
Vincent – Discovery of reverse transcriptase by Baltimore and Temin

Listener Picks

SamAir Travel Packing List
JustinPFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

Click arrow to play
Download TWiV 817 (30 MB .mp3, 50 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.

Host: Vincent Racaniello

Guest: David Tuller

Click arrow to play
Download TWiV 816 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler

Guests: Moshe Arditi and Ivet Behar

Click arrow to play
Download TWiV 815 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Weekly Picks 1:39:30

Dickson –  Mel Brooks
Kathy – Dickson’s art show at Fordham
RichSaildrone captures footage from inside Hurricane Sam
VincentA Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman

Listener Picks

KathrynProject Drawdown and the book
CharlesArrowsmith by Sinclair Lewis

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

Click arrow to play
Download TWiV 814 (30 MB .mp3, 50 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one.

Host: Vincent Racaniello

Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore

Click arrow to play
Download TWiV 813 (72 MB .mp3, 120 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker

Click arrow to play
Download TWiV 812 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Weekly Picks 1:23:38

Dickson –  Sid Caesar – The German General
Brianne – These Sea Slugs Break a Cardinal Rule of Animal Life
RichSeek by iNaturalist
AlanThe hard part of making a game is … everything
VincentColumbia Pledges That All Future Campus Construction Will Be Fossil Free

Listener Picks

BruceBat Superpowers
GaryWe’re Already Barreling Toward the Next Pandemic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

Click arrow to play
Download TWiV 811 (24 MB .mp3, 40 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Click arrow to play
Download TWiV 810 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Weekly Picks 1:45:22

Brianne –  PhD Comics: Words Said By No Academic Ever
Kathy – Bach Cello Suite #1 visualization
RichHypnagogia
VincentLandsat 9 and Wiki

Listener Picks

LoriProject Hail Mary by Andy Weir
KevinOak Savannahs

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld

Click arrow to play
Download TWiV 809 (70 MB .mp3, 117 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Weekly Picks 1:19:48

Dickson –  George Carlin: “Stuff”
Amy – The best of me by David Sedaris
RichYou could have a secret twin (but not the way you think)
AlanNuclear powered Gameboy
VincentNo, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer

Listener Picks

MichaelThe tangled history mRNA vaccines
Fernando1493 by Charles Mann

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv