TWiV 784: Virtually live from ASV

Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker

Guests: Joseph Hyzer and Moriah Szpara

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Weekly Picks

Dickson – Inside of Mars is not like Earth
Brianne – AlphaFold
Rich – Tesla motors
Alan – Diving for antique beer
Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle

Intro music is by Ronald Jenkees

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TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin

In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV 782: An antibody for all sarbecoviruses

On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Intro music is by Ronald Jenkees

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TWiV 781: My genome is left to tell the tale

The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Download TWiV 781 (64 MB .mp3, 107 min)
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Weekly Picks 1:30:44

Dickson – Current Map | U.S. Drought Monitor
Brianne – A comic strip about immune responses
Alan – Superliminal game
Vincent – Birds are dying in NJ

Listener Picks

2listening1 – Renewal
Em – Cognitive Surplus

Intro music is by Ronald Jenkees

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TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin

In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 780 (22 MB .mp3, 37 min)
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Intro music is by Ronald Jenkees

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TWiV 779: Evolving boosterism

TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Weekly Picks 1:18:36

Brianne – The Science of Chocolate Chip Cookies
Alan – Keeping Black students in STEM
Vincent – Antiviral Program for Pandemics

Listener Pick

Mark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin

In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 778 (22 MB .mp3, 37 min)
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Intro music is by Ronald Jenkees

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TWiV 777: SARS-CoV-2 fitness with Ron Fouchier

Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Ron Fouchier

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Weekly Picks 1:29:02

Brianne – The Science News Cycle
Kathy – mRNA Day Kariko & Weissman lectures and Q&A
Vincent – Just Planes

Intro music is by Ronald Jenkees

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TWiV 776: Yes! We have no pangolins

TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Weekly Picks 1:36:14

Brianne – You Know You’ve Worked Too Long in a Lab When…
Alan – Massachusetts vaccine lottery
Vincent – Coonhound paralysis

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin

In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 775 (27 MB .mp3, 44 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

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