The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:33:45

Dickson – Jazz Project: Vocals
Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter
Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett
BrianneASV Curriculum Guidelines for Virology Courses
KathyThe Snow Cruiser
Alan Rescuing bats in Ukraine
VincentWoodpeckers: The Hole Story PBS

Listener Picks

FlorenciaWorld of Viruses
MiguelFoldscope

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.

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Download TWiV 957 (26 MB .mp3, 43 min)
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Intro music is by Ronald Jenkees

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Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Cedric Feschotte and John Anthony Frank

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  • Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV 6:41
  • Cedric on TWiV 935 1:24
  • Antiviral retroviral protein (Science) 8:24
  • Stealing genes, facing consequences (Science) 47:37
  • Letters read on TWiV 956 1:04:42
  • Timestamps by Jolene. Thanks!

Weekly Picks 1:27:05

KathyWastewater Dashboard
Rich Artemis I MissionArtemis I launch; Artemis I Map
VincentPasta Grammar

Listener Picks

RichWatch a virus in the moments before it attacks
JustinRespiratory syncytial virus

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.

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Download TWiV 955 (28 MB .mp3, 47 min)
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Intro music is by Ronald Jenkees

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Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Michael Letko

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  • Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV 4:55
  • Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) 17:32
  • ACE2-dependent sarbecovirus in Russian bats (PLoS Path) 21:37
  • Letters read on TWiV 954 1:14:04
  • Timestamps by Jolene. Thanks!

Weekly Picks 1:31:26

BrianneSometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs  JupiterLunar Eclipse Blood Moon, Ice Giant
Rich Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
VincentThe 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1

Listener Pick

DebbyCelebrate Bob McDonald’s 30 years as host of Quirks & Quarks

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Download TWiV 953 (33 MB .mp3, 55 min)
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Intro music is by Ronald Jenkees

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Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

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Download TWiV 952 (63 MB .mp3, 104 min)
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Weekly Picks 1:30:22

Kathy10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich Wilderness Safaris Photographic Competition 2022
AlanMassachusetts Science Education Leadership Association, and the talk I gave to them last week
VincentAndrea Camillieri and his protagonist Inspector Montalbano

Listener Pick

FrankEconomics for the Future: Beyond the Superorganism
DebbyAs routine vaccination rates fall, polio survivor hopes her story reverses urgent trend

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Download TWiV 951 (30 MB .mp3, 50 min)
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Intro music is by Ronald Jenkees

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From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Download TWiV 950 (68 MB .mp3, 114 min)
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Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Download TWiV 949 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv