Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Download Public Health with Laurie Garrett (37 MB .mp3, 61 min)
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Intro music is by Ronald Jenkees

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Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

Guest: Paul Offit

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Download TWiV 942 (68 MB .mp3, 114 min)
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Weekly Picks

Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.

Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.

Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System
Kathy – Durable antimicrobial coating
RichOne Health
Vincent – The works of Dashiell Hammett

Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.

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Download TWiV 941 (30 MB .mp3, 50 min)
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Intro music is by Ronald Jenkees

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Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Eddie Holmes

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Download TWiV 940 (73 MB .mp3, 121 min)
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Intro music is by Ronald Jenkees

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Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Tom Monath

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Download TWiV 939 (73 MB .mp3, 121 min)
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Weekly Picks

Dickson – Jazz – Small Group #3:  Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
RichWilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
VincentRaymond Chandler and his protagonist Philip Marlowe.

Listener Picks

PhilipStudents bitten by bats inside college residence hall

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In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer’s disease.

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Download TWiV 938 (32 MB .mp3, 53 min)
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Intro music is by Ronald Jenkees

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From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.

Hosts: Vincent Racaniello

Guest: Emma Thomson

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Download TWiV 937 (50 MB .mp3, 83 min)
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Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,  resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.

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Download TWiV 936 (31 MB .mp3, 52 min)
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Intro music is by Ronald Jenkees

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Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.

Hosts: Vincent Racaniello

Guest: Cedric Feschotte

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Download TWiV 935 (50 MB .mp3, 83 min)
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Intro music is by Ronald Jenkees

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In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.

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Download TWiV 934 (32 MB .mp3, 52 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv