TWiV 818: Thor’s hammer

The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson –  John Clease
Brianne – Astronomy Picture of the Day: Swirl in the Southern Sky
Kathy – Lise Meitner  Statue is at the Humboldt University
Rich – Google has the cleanest cloud. Now it’s helping other companies go green
Vincent – Discovery of reverse transcriptase by Baltimore and Temin

Listener Picks

Sam – Air Travel Packing List
Justin – PFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 817: COVID-19 clinical update #84 with Dr. Daniel Griffin

In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 816: Long COVID and ME/CFS with David Tuller

David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees

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TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler

Guests: Moshe Arditi and Ivet Behar

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Weekly Picks 1:39:30

Dickson –  Mel Brooks
Kathy – Dickson’s art show at Fordham
Rich – Saildrone captures footage from inside Hurricane Sam
Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman

Listener Picks

Kathryn – Project Drawdown and the book
Charles – Arrowsmith by Sinclair Lewis

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 814: COVID-19 clinical update #83 with Dr. Daniel Griffin

In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 813: COVID-19 at the European Society for Clinical Virology

From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one.

Host: Vincent Racaniello

Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore

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Intro music is by Ronald Jenkees

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TWiV 812: Bespoke capsids delivered

TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker

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Weekly Picks 1:23:38

Dickson –  Sid Caesar – The German General
Brianne – These Sea Slugs Break a Cardinal Rule of Animal Life
Rich – Seek by iNaturalist
Alan – The hard part of making a game is … everything
Vincent – Columbia Pledges That All Future Campus Construction Will Be Fossil Free

Listener Picks

Bruce – Bat Superpowers
Gary – We’re Already Barreling Toward the Next Pandemic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 811: COVID-19 clinical update #82 with Dr. Daniel Griffin

In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 810: Opening Pandora’s box

TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:45:22

Brianne –  PhD Comics: Words Said By No Academic Ever
Kathy – Bach Cello Suite #1 visualization
Rich – Hypnagogia
Vincent – Landsat 9 and Wiki

Listener Picks

Lori – Project Hail Mary by Andy Weir
Kevin – Oak Savannahs

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 809: Vampire vax

TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld

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Weekly Picks 1:19:48

Dickson –  George Carlin: “Stuff”
Amy – The best of me by David Sedaris
Rich – You could have a secret twin (but not the way you think)
Alan – Nuclear powered Gameboy
Vincent – No, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer

Listener Picks

Michael – The tangled history mRNA vaccines
Fernando – 1493 by Charles Mann

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

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