TWiV 995: Viral origin stories

March 26, 2023

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

Hosts: Hosts: Vincent RacanielloDickson Despommier, Brianne Barker, and Angela Mingarelli

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Download TWiV 995 (74 MB .mp3, 123 min)
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•Register for ASV 2023
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• More evidence for SARS-CoV-2 spillover (Zenodo) 6:54
•Polio cases linked to nOPV2 (Science; GPEI statement) 26:08
•nOPV2 on TWiV 756 30:17
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) 30:17
Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology) 41:01
•HBV shifts from naked to enveloped (Nat Comm) 54:03
Letters read on TWiV 995 1:24:14
•Timestamps by Jolene. Thanks!

Weekly Picks 1:42:18

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
AngelaThe nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
BrianneScience Museums Take Stock of 1.1 Billion Objects from Around the World
Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

GaryTony Fauci on PBS
StefanieWhat Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

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