Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.
TWiV 756: Precluding problematic polio prophylaxis
- May 16, 2021
- Tagged as: coronavirus, COVID-19, gain of function, H5N1, nOPV2, OPV, pandemic, Polio, poliovirus, Sabin vaccine, SARS-CoV-2, transmission, viral, virology, virus, viruses
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.
TWiV 753: The ferret nose where the virus goes
- May 9, 2021
- Tagged as: aerosol, airborne transmission, coronavirus, COVID-19, droplet transmission, ferret, Gamaleya, H5N1, influenza virus, IPV, OPV, pandemic, polio eradication, poliomyelitis, poliovirus, sputnik, Vaccine, viral, virology, virus, viruses
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection
- April 21, 2020
- Tagged as: coronavirus, COVID-19, OPV, pandemic, poliovirus, SARS-CoV-2, viral, virology, virus, viruses
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.
TWiV 572: Your EV-D68th nervous breakdown
- November 3, 2019
- Tagged as: acute flaccid myelitis, AFM, astrocytes, cerebrospinal fluid, CSF, enterovirus D68, neurons, neurotropic, poliovirus, serology, viral, virology, virus, viruses
Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property.
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.
TWiV 567: Outbreaks and a breakout
- September 29, 2019
- Tagged as: ALIX, alphavirus, CCL2, chemokine, cytoskeleton, eastern equine encephalitis virus, EEE, ESCRT, hiv-1, IPV, OPV, outbreak, poliovirus, togavirus, Vaccine, viral, virology, virus, virus budding, viruses
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells.
From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses.
Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines.
Inside a BSL-4
