In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Weekly Picks 1:31:33

Kathy Flat pasta that turns into shapes here and here
RichAd Fontes Media Bias Chart (wiki)
VincentMartin Beck police mysteries

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GregStewart Lee on Loch Ness monster

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Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Robert Garry

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Weekly Picks 48:43, 1:36:35

Dickson 143 Optical Illusions and Visual Phenomena
Brianne The Arcane Research that Prepared Us for COVID-19
RichHidden Brain podcast
AlanA scientific theory of gist communication
VincentDivisive COVID ‘lab leak’ debate prompts dire warnings from researchers

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JonModerna Science Day

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In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans

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Weekly Picks 1:17:55

Kathy My Octopus Teacher
Rich John Wyndam classic Sci Fi: The Chrysalids, The Day of the Triffids
VincentSARS-CoV-2 Phylogeny and Spatiotemporal Spread (paper)

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TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:44:02

DicksonAnts: workers of the world
AmyLet The Record Show by Sarah Schulman
RichQAnon resembles the games I design
AlanLibrivox
VincentStratechery

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Fernando The 60-year old scientific screwup that helped COVID kill

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In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection.

Hosts: Daniel Griffin and Vincent Racaniello

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TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:47:47

BrianneDarwin’s Arch Collapses
Kathy The woman who discovered the first coronavirus
Rich “Richard Feynman: The pleasure of finding things out”
VincentCORONA Project

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JHFungus kills cicadas
AlanLiftoff by Eric Berger

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TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:50:53

DicksonFive Deeps
AmyPremonition by Michael Lewis
AlanThe Secret Life of Groceries by Benjamin Lorr
RichThe Way Ferrofluid Floats Above a Superconductor Is Unreal
VincentThreading the NEIDL

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Iradis SN15 Launch and Landing
Blue PilgrimHowland Garden Tools

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In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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