In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.

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TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 919 (61 MB .mp3, 102 min)
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Weekly Picks 1:20:34

BrianneRedactle
KathyKirigami paper replacing plastic bubble wrap
RichFirst Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent Spotted lanternfly

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AnnNASA Engineer Who Made the James Webb Space Telescope Work
SonrisaAloft – the pleasures and risks of flying

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.

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Download TWiV 918 (24 MB .mp3, 41 min)
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Intro music is by Ronald Jenkees

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Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Paul Offit

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Download TWiV 917 (70 MB .mp3, 117 min)
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Weekly Picks 1:20:41

Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
KathySolargraphic analemmas
Rich – Windy (desktop; app)
Vincent Why monkeypox is mostly hitting men who have sex with men

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MarkHand Wash Dance – NHK WORLD-JAPAN

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In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection.

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Download TWiV 916 (22 MB .mp3, 37 min)
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Intro music is by Ronald Jenkees

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TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker.

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Download TWiV 915 (70 MB .mp3, 117 min)
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Weekly Picks 1:31:57

Dickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild
BrianneOrigami antibody and virus
KathyTurbines resistant to high winds
RichObi-Wan Kenobi (TV Series)
Vincent The next epidemic may be here. The US isn’t ready for it.

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David: DALL E 2
DouglasJazz Online

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In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity.

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Download TWiV 914 (22MB .mp3, 37 min)
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Intro music is by Ronald Jenkees

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TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler.

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Weekly Picks 1:32:46

Dickson – Count Basie: April in Paris
Kathy – Bird aerodynamics & inertia: lay article, video, Nature
RichNASA Gateway (Thanks Ellis)
AlanPolio Eradication in Nigeria
Vincent The Tyranny of Merit by Michael J. Sandel

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In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants.

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Download TWiV 912 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

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TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 911 (76 MB .mp3, 127 min)
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Weekly Picks 1:41:20

BrianneA Frog So Small, It Could Not Frog
KathyA Grand Night In: The Story of Aardman
RichArchive
Vincent Bandwagoning by Heran Darwin

Intro music is by Ronald Jenkees

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