Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Picks 1:37:33

Brianne Covid restrictions prevented dengue in hundreds of thousands of people in 2020
Vincent Scotch Dual Lock 250 Reclosable Fastener

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ErinJWT Preparation and Xploration Outer Space

Intro music is by Ronald Jenkees

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TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:35:55

Dickson World’s tallest wooden building
Amy Virus hunter in the Wuhan market
RichWorldPop (example)
Vincent Karst Stone Paper

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NevaCan we vaccinate against EBV? and Paul Sutter reading a science paper

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.

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Intro music is by Ronald Jenkees

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TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:21:44

BrianneNSURP 2022
Kathy Virology Jobs
Rich10 Steps from Seed to Cup (Graphic)
AlanFathoms: The World in The Whale, by Rebecca Giggs
Vincent Worldwaterday.org

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JeremyArchaeology of Light

Intro music is by Ronald Jenkees

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TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:30:35, 1:39:29

DicksonJames Webb Space Telescope and Nature Conservancy Photo Contest
Amy A new strategy for staying one step ahead of the virus
RichSearching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis
Vincent Blacktail Studio

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RichardWater Structure and Science

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.

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Intro music is by Ronald Jenkees

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Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Michael Worobey

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Weekly Picks 1:26:55

BrianneKartchner Caverns (info from Wikipedia here)
Kathy Laminar flow and turbulent flow
RichWikipedia
Vincent The Human Lake by Carl Zimmer

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BradNASASpaceflight

Intro music is by Ronald Jenkees

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TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

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Weekly Picks 1:13:59

DicksonShip found at the bottom of the sea
Amy Vaccinating kids has never been easy
Vincent State data and CDC data on children and COVID-19

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Andrew – Books by Randall Munroe

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In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.

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Intro music is by Ronald Jenkees

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TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks 1:38:46

BrianneThe Dinosaur Age May Have Ended in Springtime
Alan The Track of the Typhoon, and me reading it.
Rich 12 Monkeys
Vincent Anna Mason’s Art Channel

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RichardSARS-CoV-2 in animals: Situation report #9
JasonCounting App and CountThings from Photos

Intro music is by Ronald Jenkees

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