In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld

Guest: Susan Weiss

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Download TWiV 734 (79 MB .mp3, 131 min)
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Weekly Picks 1:55:18

BrianneTiktok of How mRNA Vaccines Work
AlanDark
RichUnmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
AmyMOMA Calder exhibit, reviewed in NYTimes
VincentRipple Training (free YouTube channel)

Listener Picks

Ruth100 million year old seafloor bacteria resuscitated
IradisLinda Zall, CIA spy for science

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 733 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

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Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 732 (67 MB .mp3, 112 min)
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Weekly Picks 1:34:05

Dickson10 amazing science tricks with liquids
BrianneHow Do Blind Worms See the Color Blue?
RichStatewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children
KathyDark side of the moon as it crosses Earth
VincentWasdkeyboards and Novelkeys

Listener Pick

BronwenCOVID Performance Index

Intro music is by Ronald Jenkees

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On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker

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Download TWiV 731 (69 MB .mp3, 115 min)
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Weekly Picks 1:35:36

BrianneWho Would Kidnap a Space Telescope?
AlanRadio Garden
RichCountries with more obesity have had  more covid deaths on average
VincentConcord Aerospace

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 730 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

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Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Matt Frieman

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Download TWiV 729 (70 MB .mp3, 117 min)
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Weekly Picks 1:43:29

DicksonCovid-19 deaths per million ranked by average income
BrianneKFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard
RichThe Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’ (wiki)
KathyQuadrantid meteor (Quadrantids)
VincentHigher Superstition by Paul Gross and Norman Levitt

Intro music is by Ronald Jenkees

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TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Download TWiV 728 (79 MB .mp3, 132 min)
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Weekly Picks 1:53:57

DicksonWild animal photos
BrianneGreater than COVID
AlanWHO report on infodemic response
RichReference Guide to the International Space Station
Vincent3D Molecular Designs

Listener Picks

LisbethHave the new jab
KarenCholera exhibit at Museum of Trades and Crafts

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 727 (21 MB .mp3, 35 min)
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Intro music is by Ronald Jenkees

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Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.

Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler

Guest: Janet Iwasa

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Download TWiV 726 (68 MB .mp3, 113 min)
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  • The Animation Lab 45:04, 1:16:38
  • SARS-CoV-2 animation 51:46
  • Documents for J&J COVID-19 vaccine review (FDA) 1:17:51
    • Phase III data (pdf) 1:18:39
    • Slide presentation of data (pdf) 1:22:08
    • Addendum (pdf) 1:29:41
    • Summary of v-Safe data (pdf) 1:34;50
  • Timestamps by Jolene. Thanks!

Weekly Picks 1:39:07

BrianneHow T cells see SARS-CoV2
RichIce bubbles in Lago Bianco, Switzerland
KathyMusic in COVID-19 control tents
VincentPerseverance runs on processors used in 1990s iMacs

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv