TWiV 1139: Long COVID with Dr. Judith Bruchfeld

Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.

Hosts: Vincent Racaniello

Guest: Judith Bruchfeld

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Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

TWiV 1138: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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Intro music is by Ronald Jenkees

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TWiV 1137: Dengue is not BANAL

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:16:33

Kathy – Using big data to improve traffic light timing
Rich – Dillo Dirt
Alan – Dueling Banjos on banjo and kora
Vincent – The world’s most expensive dinosaur and more

Listener Pick

Mike – Science through a glass darkly
Lisa – “On A Mission“ Season Four

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1136: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have affected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.

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  • In physicians and hospitals, we trust (JAMA Network) 2:50
  • Are there benefits for delaying seasonal influenza vaccine selections (JID) 9:05
  • Personal protective effect for wearing surgical face masks in public spaces (the BMJ) 14:02
  • COVID-19 national trend (CDC) 16:28
  • COVID-19 deaths (CDC)
  • Cardiovascular safety of different COVID-19 vaccination (Nature Comm) 18:12
  • Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) 20:11
  • Where to get pemgarda (Pemgarda)
  • CDC Quarantine guidelines (CDC)
  • Early phase of SARs-CoV-2 infection (COVID.gov)
  • NIH COVID-19 treatment guidelines (NIH)
  • Infectious Disease Society guidelines for treatment and management (ID Society)
  • Drug interaction checker (University of Liverpool)
  • Molnupiravir safety and efficacy (JMV)
  • Convalescent plasma recommendation for immunocompromised (ID Society)
  • Managing healthcare staffing shortages (CDC)
  • Steroids, dexamethasone at the right time (OFID)
  • Anticoagulation guidelines (hematology.org)
  • Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology) 23:30
  • Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health) 25:49
  • Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine) 28:44
  • The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports) 31:05
  • Contribute to our Floating Doctors fundraiser 32:58
  • Letters read on TWiV 1136 33:38
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1135: Resistance is not always futile

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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Weekly Picks 1:35:36

Angela – Animal research is not always king
Brianne – Why the US has more tornadoes than any other country
Dickson – Earth’s core has slowed so much it’s moving backward
Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove
Vincent – Seventh patient ‘cured’ of HIV: why scientists are excited

Listener Pick

Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1134: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.

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Intro music is by Ronald Jenkees

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TWiV 1133: Gain of function makes us safer

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:36:40

Dickson – Elemental sulfur found on Mars
Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024
Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?)
Alan – Nature sent an investigative reporter to a predatory conference
Vincent – Coal-filled trains are likely sending people to the hospital

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1132: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.

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Intro music is by Ronald Jenkees

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TWiV 1131: Mootant influenza H5N1 virus

TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

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Weekly Picks 1:32:57

Dickson – Stockholm Wood City
Rich – “The Wide Wide Sea” by Hampton Sides
Vincent – Tour de France stage 12

Listener Picks

Amy – Earth Forced from the Protective Heliosphere: What Do We know?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1130: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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