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Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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Download TWiV 608 (35 MB .mp3, 57 min)
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Intro music is by Ronald Jenkees.

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CoV_bank

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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Download TWiV 607 (41 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees.

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CoV_bank

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin

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Download TWiV 606 (69 MB .mp3, 114 min)
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Intro music is by Ronald Jenkees.

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Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric, Mark Heise, and Nat Moorman

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Download TWiV 605 (32 MB .mp3, 53 min)
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Intro music is by Ronald Jenkees.

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Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Download TWiV 604 (39 MB .mp3, 64 min)
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  • Nonpathogenic enteroviruses to prevent human disease (pdf) 6:13
  • OPV for COVID-19 (pdf) 17:56
  • Enteroviruses to prevent human infections (pdf) 7:08
  • Image credit
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

CoV_bank

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 603 (70 MB .mp3, 116 min)
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Intro music is by Ronald Jenkees.

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Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

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Download TWiV 602 (45 MB .mp3, 74 min)
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Intro music is by Ronald Jenkees.

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Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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Download TWiV 601 (34 MB .mp3, 56 min)
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Intro music is by Ronald Jenkees.

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Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 600 (69 MB .mp3, 113 min)
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Intro music is by Ronald Jenkees.

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Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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Download TWiV 599 (77 MB .mp3, 128 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv