In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.

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Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi

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Weekly Picks 1:11:01

BrianneAPod Stars and Globules in the Running Chicken Nebula
KathyBioRender Poster Builder
RichThe Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
Vincent Baumgartner Restoration

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JTime, Einstein, and the coolest stuff in the Universe

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This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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DicksonWebb Telescope’s coldest instrument reaches operating temperature
BrianneVideo of a CTL killing a tumor cell
RichOur Unfinished Pandemic (On the Media Podcast)
Vincent Lý Thị Ca

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In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.

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Intro music is by Ronald Jenkees

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Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Richard Plemper

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BrianneBioRender Poster Builder
AlanHexbug cat toys
Vincent US Mint 2019 American Innovation Coin – PA – Polio Vaccine

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SueAmerican Visionary Art Museum
FrazerVaccine trial for killer elephant virus

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TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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DicksonKetanji Brown Jackson confirmed to US Supreme Court
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Rich Lady Bird Johnson Wildflower Center
Vincent Martijn Doolaard

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AnnImmunological memory to SARS-CoV-2 infection and vaccines
ChrisIsoplexis

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In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.

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Intro music is by Ronald Jenkees

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TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks 1:25:27

Brianne The Search for a Model Octopus That Won’t Die After Laying Its Eggs
RichVaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White)  and The Cutter Incident by Paul Offit
Vincent Simply Put: Vaccines Save Lives

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Rich‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag
NevaElin Thomas, UK textile artist
VikiHistory of English Podcast

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Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Amy Ben Franklin by Ken Burns
Vincent – Thoughts on a second booster: Offit and Krause/Borio

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PhilipHistory of Clemson Blue Cheese
JackPipeline and A Special Report on Polio

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In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in hamsters, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.

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Download TWiV 883 (27 MB .mp3, 45 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv