Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 665 (106 MB .mp3, 177 min)
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Intro music is by Ronald Jenkees

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On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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  • Coronavirus is mutating (Nature) 9:29
  • Seasonal CoV immunity is short (Nat Med) 18:16
  • Sorry, no link to the fake science document! 40:44
  • Letters read on TWiV 664 1:08:02
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.

The British people can face any misfortune with fortitude & buoyancy as long as they are convinced that those in charge of their affairs are not deceiving them, or are not dwelling in a fool’s paradise.
— Winston Churchill

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 663 (94 MB .mp3, 157 min)
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Intro music is by Ronald Jenkees

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The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.

Host: Vincent Racaniello

Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou

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Download TWiV 662 (31 MB .mp3, 52 min)
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  • Purchase PoV 5e Volumes 1 + 2 (link)
  • Purchase PoV 5e Volume 1 (link)
  • Purchase PoV 5e Volume 2 (link)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ralph Baric

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Download TWiV 661 (70 MB .mp3, 116 min)
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Intro music is by Ronald Jenkees

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Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 660 (95 MB .mp3, 159 min)
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Intro music is by Ronald Jenkees

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Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Christian Drosten

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Download TWiV 659 (72 MB .mp3, 120 min)
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Intro music is by Ronald Jenkees

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Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott’s $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Guest: Daniel Griffin

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Download TWiV 658 (85 MB .mp3, 141 min)
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Intro music is by Ronald Jenkees

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Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Shane Crotty

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Download TWiV 657 (80 MB .mp3, 133 min)
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Intro music is by Ronald Jenkees

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Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.

Hosts: Vincent Racaniello, Dickson DespommierRich Condit, and Brianne Barker

Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce

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Download TWiV 656 (85 MB .mp3, 141 min)
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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv