Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Download Immune 55 (42 MB .mp3, 69 min)
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Music by Steve Neal.
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Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Download Immune 54 (97 MB .mp3, 80 min)
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Music by Steve Neal.
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Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Download Immune 53 (97 MB .mp3, 80 min)
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Music by Steve Neal.
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Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Gabriel Victora

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Download Immune 52 (76 MB .mp3, 63 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Nikhil Joshi

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Download Immune 51 (76 MB .mp3, 63 min)
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  • Creation of NINJA mice (Nature Biotech) 10:00
  • Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 50 (57 MB .mp3, 94 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Keke Fairfax

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Download Immune 49 (57 MB .mp3, 94 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Timothy Hand

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Download Immune 48 (45 MB .mp3, 75 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 47 (43 MB .mp3, 71 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 46 (50 MB .mp3, 84 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv