Immune 58: Gut B cells awry in ulcerative colitis

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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Immune 57: Bacteria, the new cure for wounds?

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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Immune 56: Flip flops on the thymic beach with Al Singer

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Al Singer

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Music by Steve Neal.
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Immune 55: Cells that suck at their job

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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Immune 54: Asthma and aging

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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Immune 53: Dendritic cell robbers

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
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Immune 52: B cell boot camp with Gabriel Victora

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Gabriel Victora

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Music by Steve Neal.
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Immune 51: Teenage NINJA mice with Nikhil Joshi

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Nikhil Joshi

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  • Creation of NINJA mice (Nature Biotech) 10:00
  • Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune 50: Red blood cells are immune sentinels

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
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Immune 49: I fell in love with worms with Keke Fairfax

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Keke Fairfax

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Music by Steve Neal.
Immune logo image by Blausen Medical

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