Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker

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Download Immune 71 (53 MB .mp3, 73 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Download Immune 70 (42 MB .mp3, 70 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Kevin Ng

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Download Immune 69 (42 MB .mp3, 70 min)
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Music by Steve Neal.
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Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

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Download Immune 66 (41 MB .mp3, 68 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Download Immune 67 (45 MB .mp3, 76 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Download Immune 66 (45 MB .mp3, 76 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Cindy, Steph, Brianne, and Vincent do a rapid review of 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Download Immune 64 (66 MB .mp3, 110 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv