Immune - Part 4

Immune

Immune 48: Environmental enteric dysfunction with Timothy Hand

September 13, 2021
Tagged as: environmental enteric dysfunction, immune, immunology, mouse model, oral vaccine failure, regulatory T cells, RORgammaT+FOXP3+ cells, Treg cells

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Timothy Hand

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Mouse model for EED (Immunity) 19:02
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 47: Trapping viruses in NETs

August 23, 2021
Tagged as: antibody, Fc receptor, IgA, immune, immunology, influenza virus, NETosis, neutrophil, neutrophil extracellular trap

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Antiviral IgA potentiates NETosis (PNAS) 7:03
Letters read on Immune 47 58:26
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 46: Bats don’t STING like a bee

July 27, 2021
Tagged as: bat, cGAS, DNA sensing, immune, immunology, interferon, STING, virus reservoir, zoonosis

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Dampened STING in bats (Cell Host Micr) 26:38
Lessons from bat defenses (Nature)
Bat immune systems (Front Immune)
Bats protected from genotoxic compounds (Nat Comm) 11:05
Letters read on Immune 46 53:27
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 45: Immune messages

June 16, 2021
Tagged as: antibody, B cells, complement, COVID-19, germinal centers, immune, immunology, macrophages, T cells, vaccine

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Letters read on Immune 45 2:45
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 44: Got IgA on the brain

May 17, 2021
Tagged as: antibody, EAE, IgA, immune, immunology, immunosuppression, multiple sclerosis, neuroinflammation, plasma cell

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Intestinal IgA regulates neuroinflammation (Cell) 9:56
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box

March 24, 2021
Tagged as: cancer, CAR-MAC, CAR-NK, CAR-T cell therapy, immune, immunology, macrophage, NK cell, tumor

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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CAR-T cell therapy on Immune 4 7:48
Recent CAR-T cell advances (Nat Rev Cancer)
Status of CAR-T cell therapy (CancerConnect)
CAR-MAC for cancer (Nat Biotech) 48:37
CAR-MAC for COVID-19 (bioRxiv) 1:04:06
Letters read on Immune 43 1:08:34
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler

February 13, 2021
Tagged as: antibody, B cells, coronavirus, COVID-19, immune, immunology, memory B cells, pandemic, SARS-CoV-2

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Christian Gaebler

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Evolution of antibody immunity to SARS-CoV-2 (Nature) 10:18
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 41: Zebrafish immunology with Madina Wane

January 25, 2021
Tagged as: anosmia, COVID-19, fish, gills, immune, immunology, pandemic, SARS-CoV-2, zebrafish

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Madina Wane

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Black in Immuno (YouTube) 9:39
Cytokines and gill homeostasis (J Immune) 1:16:44
Zebrafish model of COVID-19 olfactory loss (bioRxiv) 32:00
Overview of fish vaccination (pdf)
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune

Immune 40: COVID-19 nuances

December 30, 2020
Tagged as: antibody, coronavirus, COVID-19, immune, immunity, immunology, pandemic, SARS-CoV-2, T cell, T cell exhaustion, vaccine

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Immune response during common cold CoV infection (Epidem Infect) 53:26
Summary of diagnostic tests (NAS) 1:27:06
Letters read on Immune 40 47:59
Time stamps by Jolene. Thanks!

Music by Steve Neal.
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Immune

Immune 39: A Tonka Truck full of salt

December 1, 2020
Tagged as: coronavirus, COVID-19, cross reactive memory, immune, immunodominant epitopes, immunology, long-term COVID, mucosal surface, pandemic, peptide megapolis, SARS-CoV-2, T cell epitopes, T cell receptor

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Reflections of a COVID-19 long hauler (JAMA) 4:27
Not a cytokine storm in COVID-19 (JCIO) 56:52
Letters read on Immune 39 2:41
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

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