Immune - Part 6

Immune

Immune 28: Fish immunology

February 8, 2020
Tagged as: IgT, immune, immunology, microbiome, mucosal antibody, pathogen control, rainbow trout, teleost

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

Click arrow to play
Download Immune 28 (35 MB .mp3, 56 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Evolution of mucosal Ig in rainbow trout (Sci Immunol) 19:12
Fish olfactory neurons mediate rapid immune response (PNAS) 39:32
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 27: Trained immunity

January 11, 2020
Tagged as: enhancer, H3K4Me1, immune, immune memory, immunology, innate immunity, LPS, methylation, NK cells, sepsis

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 27 (57 MB .mp3, 94 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

H3K4me1 mark on memory-like NK cells (Cell Rep) 14:42
Letters read on Immune 27 1:08:37
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:22:07

Steph – Rotavirus & polio vaccines should be separated (article, paper)
Cindy – Diversify Immunology
Vincent – No winter break from publish or perish

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 26: Measles erases immune memory

November 28, 2019
Tagged as: immune, immunology, immunosuppression, lymphocytes, measles virus, MMR vaccine, plasma cells, viral, VirScan, virus

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

Click arrow to play
Download Immune 26 (59 MB .mp3, 98 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Measles virus infection diminishes pre-existing antibodies (Science) 21:33
Public epitope #1 (TWiV 342) 33:12, 1:11:35
Incomplete reconstitution of B cell pools after measles (Sci Immunol) 1:14:15, 1:21:59
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 25: Remembrance of antigen encounters past

November 1, 2019
Tagged as: antigen presentation, CD8+ T cells, glycolysis, high fiber diet, immune, immunology, microbiome, oxidative phosphorylation, short chain fatty acids, T cell memory, TCA cycle

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 25 (50 MB .mp3, 82 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

CD8+ T cell memory needs microbiome derived fatty acids (Immune) 2:46
Image credit: Principles of Virology 4e
Time stamps by Jolene. Thanks!
Letters read on Immune 25 1:01:52

Weekly Science Picks 1:09:20

Stephanie – This Week in Neuroscience
Cindy – Graduate Abuse by Derek Lowe
Vincent – Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 24: Unlucky IL-13

September 19, 2019
Tagged as: allergic responses, anaphylaxis, follicular T cell, IgE, immune, immunology, mast cells, T helper cell

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 24 (54 MB .mp3, 89 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

New type of T helper cell drives anaphylaxis (Science) 2:41, 32:50
Image credit
Time stamps by Jolene. Thanks!
Letters read on Immune 24 1:12:56

Weekly Science Picks 1:22:54

Cindy – Lasker Award 2019
Vincent – Eleanor’s Breakthrough video

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 23: How to tell a mouse from a mouse

August 14, 2019
Tagged as: backcrossed, congenial, immune, immunology, inbred mice, laboratory mouse, RNA-seq

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 23 (53 MB .mp3, 87 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Genetic variation in laboratory mice (Immunity) 11:02
Time stamps by Jolene. Thanks!
Vaccines and Your Child 1:09:11
Letters read on Immune 23 1:05:33

Weekly Science Picks 1:19:10

Steph – University of Alaska budget crisis
Cindy – 90% survival following new Ebolavirus treatments
Vincent – Immunology videos at Blausen Medical

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 22: Engineering B cells

July 31, 2019
Tagged as: allelic exclusion, antibody, B cell, CRISPR/Cas, heavy chain, immune, immunology, light chain, vaccine

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 22 (48 MB .mp3, 78 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Engineering B cells to produce antiviral antibodies (Sci Immun) 5:45
Time stamps by Jolene. Thanks!
Letters read on Immune 22 4:18, 55:14

Weekly Science Picks 1:07:59

Steph – Breath of fresh air
Cindy – Biologist found dead
Vincent – Nobel Prizes and Nature’s Surprises by Erling Norrby

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 21: Islets of Langelhans

June 12, 2019
Tagged as: autoimmunity, B cells, BCR, dual expressing lymphocytes, immune, immunology, public BCR, T cells, TCR, type I diabetes

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 21 (53 MB .mp3, 87 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Dual receptor lymphocytes and type I diabetes (Cell) 29:47
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:18:43

Steph – Unique Scientists
Cindy – Researcher app
Vincent – STLR Conversations Podcast

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 20: In defense of death

May 29, 2019
Tagged as: blood clotting, gasdermin, immune, immunology, inflammasome, inflammation, pyroptosis, thrombosis, tissue factor

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 20 (54 MB .mp3, 88 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Inflammasome activation triggers blood clotting (Immunity) 4:06
Rotavirus and Nlrp9b inflammasome (Nature) 53:55
Societal Amnesia and vaccines by Cindy Leifer 1:20:22
Image credit
Letters read on Immune 20 58:01
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:13:56

Steph – iBiology Immunology Course
Cindy – Changing vaccine hesitancy
Vincent – Bad Advice by Paul Offit (and Vaccines and Your Child)

Listener Pick

Steve – An Elegant Defense

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 19: Mom’s the word

April 17, 2019
Tagged as: antibody, herpes simplex virus, immune, immunology, neonatal herpes, neurotropic, placental antibody transfer, vaccination, vaccine, virus

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Click arrow to play
Download Immune 19 (47 MB .mp3, 76 min)
Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

Maternal immunization protects offspring (Sci Trans Med) 5:42
Diversity of herpesvirus in neonates (TWiV 540) 4:48
Mariana Mazzucato on Freakonomics 1:05:09
Letters read on Immune 19 57:02
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:10:05

Steph – iNaturalist
Cindy – Taking a break is also hard work
Vincent – Immunology Wall Posters

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

« Previous 1 … 4 5 6 7 8 Next »

Links for this episode

Links for this episode

Weekly Science Picks 1:22:07

Links for this episode

Links for this episode

Weekly Science Picks 1:09:20

Links for this episode

Weekly Science Picks 1:22:54

Links for this episode

Weekly Science Picks 1:19:10

Links for this episode

Weekly Science Picks 1:07:59

Links for this episode

Weekly Science Picks 1:18:43

Links for this episode

Weekly Science Picks 1:13:56

Listener Pick

Links for this episode

Weekly Science Picks 1:10:05

Contribute