In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.

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Intro music is by Ronald Jenkees

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TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks 1:25:27

Brianne The Search for a Model Octopus That Won’t Die After Laying Its Eggs
RichVaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White)  and The Cutter Incident by Paul Offit
Vincent Simply Put: Vaccines Save Lives

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Rich‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag
NevaElin Thomas, UK textile artist
VikiHistory of English Podcast

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Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.

Hosts: Vincent Racaniello and Amy Rosenfeld

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Weekly Picks 1:37:40

Amy Ben Franklin by Ken Burns
Vincent – Thoughts on a second booster: Offit and Krause/Borio

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PhilipHistory of Clemson Blue Cheese
JackPipeline and A Special Report on Polio

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in hamsters, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.

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Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Picks 1:37:33

Brianne Covid restrictions prevented dengue in hundreds of thousands of people in 2020
Vincent Scotch Dual Lock 250 Reclosable Fastener

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ErinJWT Preparation and Xploration Outer Space

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TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:35:55

Dickson World’s tallest wooden building
Amy Virus hunter in the Wuhan market
RichWorldPop (example)
Vincent Karst Stone Paper

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NevaCan we vaccinate against EBV? and Paul Sutter reading a science paper

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In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.

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TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:21:44

BrianneNSURP 2022
Kathy Virology Jobs
Rich10 Steps from Seed to Cup (Graphic)
AlanFathoms: The World in The Whale, by Rebecca Giggs
Vincent Worldwaterday.org

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JeremyArchaeology of Light

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TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:30:35, 1:39:29

DicksonJames Webb Space Telescope and Nature Conservancy Photo Contest
Amy A new strategy for staying one step ahead of the virus
RichSearching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis
Vincent Blacktail Studio

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RichardWater Structure and Science

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In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv