Immune - Part 8

Immune

Immune 15: Happy neu-trophil year

December 22, 2018
Tagged as: diapedesis, immune, immunology, leukocyte, neutrophil, neutrophil net, neutrophil rolling, tether and sling

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Slings enable neutrophil rolling (Nature) 33:20
Sling video (La Jolla Inst Allergy Immunol) 32:43
Neutrophil extracellular traps kill bacteria (Science) 50:45
Neutrophil review (Sci Immunol)
Image credit
Letters read on Immune 15 1:04:06
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:14:01

Steph – Should reviewers remain anonymous?
Cindy – Breast Cancer Research Foundation
Vincent – Initiative to End Paywalls (The Scientist)

Listener Pick

Jim – Eat to Live (YouTube)

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 14: Braking bad

November 14, 2018
Tagged as: cancer immunotherapy, CTLA-4, immune, immune checkpoint inhibitor, immunology, immunotherapy, James Allison Tasuku Honjo, Nobel Prize, PD-1, PDL-1, T cell

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

2018 Nobel Prize in Medicine 5:53
2018 Nobel Prize in Medicine (pdf)
What’s in a name? (Can Res Inst) 38:19
Checkpoint inhibitor failures (Nature) 1:03:06
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:13:25

Steph – Immunobites
Cindy – List of immunology Nobels
Vincent – Prof. Barker’s Immunology lectures

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 13: Do no harm

October 20, 2018
Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;amp;amp;gt;

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Links for this episode

Host lncRNA binds RIG-I (Cell) 18:16
Microbe Art at virology blog 1:09:40
Letters read on Immune 13 50:59
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:07:18

Steph – That’s Pediatrics Podcast
Cindy – Trilobite Glassworks
Vincent – Research!America

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 12: Systems immunology

September 19, 2018
Tagged as: cell sorting, cord blood, CyTOF, FACS, immune, immune system, immunology, microbiome, newborn children, postnatal immunity, RNAseq, systems immunology

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;amp;gt;

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Links for this episode

Immune system development in newborns (Cell) 25:15
Dead parrots and live wildcats (TWiV 185) 1:00:35
Pathogenesis card game (JAMA) 1:04:06
Letters read on Immune 12 55:33

Weekly Science Picks 1:04:07

Steph – Kaleidoscopean
Cindy – 500 women scientists
Vincent – NIH budget increase 2019

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 11: Immunomimetic designer cells

August 18, 2018
Tagged as: biofilm, gene network, immune, immunology, immunomimetic, implant infection, inflammation, innate immune response, lysostaphin, MRSA, Staphylococcus aureus

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.

Hosts: Vincent Racaniello and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Immunomimetic designer cells (Cell) 1:58, 26:46
Antimicrobial drug resistance (NIH) 4:40, 13:51
Image credit 36:45
Letters read on Immune 11 46:59

Science Picks 1:01:59

Cindy – No Tdap link to autism
Vincent – Unpaywall

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 10: Immune goes viral

July 21, 2018
Tagged as: antibodies, antibody escape mutants, broadly neutralizing antibodies, HIV-1, immune, immunology, Rebecca Lynch

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Rebecca Lynch

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 9: Neither mice nor lamprey lie

June 20, 2018
Tagged as: antibodies, hagfish, immune, immunity, immunoglobulins, jawed vertebrates, jawless vertebrates, lamprey, leucine rich repeat, variable lymphocyte receptor, VLR

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Lamprey VLR response to influenza virus (eLife) 34:14
VLR-based immunity (Ann Rev Immunol)
How the Immune System Works 1:13:11
A Commotion in the Blood 1:13:35
Immune merchandise 1:05:34
Image credit 34:53
Letters read on Immune 9 51:27

Weekly Science Picks 1:20:05

Steph – Jon Yewdell on TWiV (208, 467)
Cindy – No polio in Venezuela
Vincent – Is gaming addiction a thing?

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Uncategorized

Immune 8: Staying warm with γδ T cells

May 25, 2018
Tagged as: homeostasis, IL-17A, immune, immunology, T cells, thermogenesis, γδT cells

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) 5:40
γδ17 T cells cells at epithelial barriers (Nat Rev Immunol) 23:35
Image credit
Letters read on Immune 8 59:14

Weekly Science Picks 1:10:45

Steph – Polycystic ovary syndrome and anti-Mullerian hormone
Cindy – Foldscope (Ted talk)
Vincent – Virology Lectures 2018

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 7: Contradictory complements in Alzheimer’s Disease

April 18, 2018
Tagged as: AD, Alzheimer's disease, C1q, complement, immune, immunology, MAC, mouse model, synapse, synaptic pruning

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer’s disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Complement and microglia cause synapse loss in Alzheimer’s (Science) 28:42
Superresolution structured illumination microscopy 48:31, 1:07:33
Image credit

Weekly Science Picks 1:06:50

Steph – Social Media for Social Change in Science and Structured Illumination Microscopy video
Cindy – 314 Action
Vincent – Making American great again requires acting on scientific knowledge

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 6: Potent antiviral antibodies without somatic mutation

March 16, 2018
Tagged as: antibody, B cell, epitope, F protein, IgG, IgM, immune, immune response, immunology, lymph node, respiratory syncytial virus, somatic hypermutation, V(D)J recombination, vaccine enhanced disease

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Potent anti-RSV antibodies without somatic hypermutation (Immunity) 3:38, 33:43
History of vaccine enhanced RSV disease (Clin Vacc Immunol) 9:41
Image credit
Letters read on Immune #6 61:45

Weekly Science Picks 78:56

Steph – REACTOME project (free icons)
Cindy – Gender Imbalance in Stories
Vincent – Trump, Tell Us About Your Flu Shot

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

« Previous 1 … 6 7 8 9 Next »

Immune 15: Happy neu-trophil year

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Weekly Science Picks 1:14:01

Listener Pick

Immune 14: Braking bad

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Weekly Science Picks 1:13:25

Immune 13: Do no harm

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Weekly Science Picks 1:07:18

Immune 12: Systems immunology

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Weekly Science Picks 1:04:07

Immune 11: Immunomimetic designer cells

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Science Picks 1:01:59

Immune 10: Immune goes viral

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Immune 9: Neither mice nor lamprey lie

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Weekly Science Picks 1:20:05

Immune 8: Staying warm with γδ T cells

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Weekly Science Picks 1:10:45

Immune 7: Contradictory complements in Alzheimer’s Disease

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Weekly Science Picks 1:06:50

Immune 6: Potent antiviral antibodies without somatic mutation

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Weekly Science Picks 78:56

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