Immune - Part 8

Immune

Immune 36: Aberrant immunity in COVID-19

October 21, 2020
Tagged as: antibody, coronavirus, COVID-19, germinal center, herd immunity, humoral immunity, immune, immune memory, immunology, pandemic, SARS-CoV-2, somatic hypermutation

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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Loss of germinal centers in severe COVID-19 patients (Cell) 11:01
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 35: SARS-CoV-2 antibodies

September 23, 2020
Tagged as: antibodies, coronavirus, correlates of protection, COVID-19, immune, immunology, pandemic, SARS-CoV-2, spike protein

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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COVID-19 severity linked to antibody levels (bioRxiv) 7:12
Review of antibody mediated immunity to coronaviruses (Nat Comm) 45:51
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 34: Coronavirus cross-reacting T cells

August 25, 2020
Tagged as: CD4 T cell, coronavirus, COVID-19, epitope, MHC molecule, pandemic, peptide, SARS-CoV-2, T cell, T cell epitope, T cell receptor, viral, virology, virus, viruses

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Cross-reactive coronavirus CD4+ T cells (Science) 5:46
Immune misfiring in severe COVID-19 (Nature) 50:05
A COVID-19 riddle for the immune system (Nature) 52:06
Letters read on Immune 34 59:57
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 33: COVID-19 immunotypes

July 28, 2020
Tagged as: antibody, B cells, CD4 cells, CD8 cells, cell sorting, COVID-19, cytokines, FACS profiling, immune, immunology, immunotypes, lymphocytes, pandemic, SARS-CoV-2, T cells

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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CD8 cells defend against SARS-CoV (J Virol) 3:36
Deep immune profiling of COVID-19 patients (Science) 8:30
Letters read on Immune 33 1:11:05
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 32: Immunology of COVID-19, part four

June 5, 2020
Tagged as: antibody, COVID-19, cytokine signature, cytokine storm, immune, immunology, immunopathology, SARS-CoV-2, T cell

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Keep CoV off campus (NY Times) 10:17
Inflammatory cytokines predict COVID-19 death (medRxiv) 16:36
Imbalanced host response drives COVID-19 (Cell) 23:57
Convergent antibody responses in COVID-19 patients (bioRxiv) 32:53
Cross neutralization of SARS-CoV-2 by SARS-CoV mAb (Nature) 45:56
Human T-cell responses to SARS-CoV-2 (Cell) 36:12, 41:11
DNA vaccine protects rhesus macaques (Science) 47:02
Replicon RNA vaccine protects macaques (bioRxiv) 47:03
Letters read on Immune 32 1:04:37
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 31: Immunology of COVID-19, part three

May 8, 2020
Tagged as: antibody, BCG, COVID-19, immune, immunology, OPV, SARS-CoV-2, vaccine

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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How long will a vaccine really take? (NYTimes) 37:15
Humoral immunity in NYC COVID-19 patients (medRxiv) 43:13
D614G is just a SNP (TWiEVO 55) 32:54
Letters read on Immune 31 37:15
Image credit
Transcript of this episode (html, pdf)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 30: Immunology of COVID-19, part two

April 17, 2020
Tagged as: antibody, coagulation, coronavirus, COVID-19, cytokine storm, IL6, immune, immunology, SARS-CoV-2, steroids

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 29: Immunology of COVID-19

March 31, 2020
Tagged as: coronavirus, COVID-19, immune, immunology, immunopathology, pandemic, SARS-CoV-2, viral, virology, virus

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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ACE2 in oral mucosa (I J Oral Sci) 13:32
IL6 predictor of COVID-19 death (Int Care Med) 41:38
Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) 1:19:18
Antibody to SARS-CoV wanes (J Immunol)
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 28: Fish immunology

February 8, 2020
Tagged as: IgT, immune, immunology, microbiome, mucosal antibody, pathogen control, rainbow trout, teleost

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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Evolution of mucosal Ig in rainbow trout (Sci Immunol) 19:12
Fish olfactory neurons mediate rapid immune response (PNAS) 39:32
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 27: Trained immunity

January 11, 2020
Tagged as: enhancer, H3K4Me1, immune, immune memory, immunology, innate immunity, LPS, methylation, NK cells, sepsis

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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H3K4me1 mark on memory-like NK cells (Cell Rep) 14:42
Letters read on Immune 27 1:08:37
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:22:07

Steph – Rotavirus & polio vaccines should be separated (article, paper)
Cindy – Diversify Immunology
Vincent – No winter break from publish or perish

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

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Immune 36: Aberrant immunity in COVID-19

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Immune 35: SARS-CoV-2 antibodies

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Immune 34: Coronavirus cross-reacting T cells

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Immune 33: COVID-19 immunotypes

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Immune 32: Immunology of COVID-19, part four

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Immune 31: Immunology of COVID-19, part three

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Immune 30: Immunology of COVID-19, part two

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Immune 29: Immunology of COVID-19

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Immune 28: Fish immunology

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Immune 27: Trained immunity

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Weekly Science Picks 1:22:07

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