Immune - Part 9

Immune

Immune 26: Measles erases immune memory

November 28, 2019
Tagged as: immune, immunology, immunosuppression, lymphocytes, measles virus, MMR vaccine, plasma cells, viral, VirScan, virus

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

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Measles virus infection diminishes pre-existing antibodies (Science) 21:33
Public epitope #1 (TWiV 342) 33:12, 1:11:35
Incomplete reconstitution of B cell pools after measles (Sci Immunol) 1:14:15, 1:21:59
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 25: Remembrance of antigen encounters past

November 1, 2019
Tagged as: antigen presentation, CD8+ T cells, glycolysis, high fiber diet, immune, immunology, microbiome, oxidative phosphorylation, short chain fatty acids, T cell memory, TCA cycle

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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CD8+ T cell memory needs microbiome derived fatty acids (Immune) 2:46
Image credit: Principles of Virology 4e
Time stamps by Jolene. Thanks!
Letters read on Immune 25 1:01:52

Weekly Science Picks 1:09:20

Stephanie – This Week in Neuroscience
Cindy – Graduate Abuse by Derek Lowe
Vincent – Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 24: Unlucky IL-13

September 19, 2019
Tagged as: allergic responses, anaphylaxis, follicular T cell, IgE, immune, immunology, mast cells, T helper cell

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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New type of T helper cell drives anaphylaxis (Science) 2:41, 32:50
Image credit
Time stamps by Jolene. Thanks!
Letters read on Immune 24 1:12:56

Weekly Science Picks 1:22:54

Cindy – Lasker Award 2019
Vincent – Eleanor’s Breakthrough video

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 23: How to tell a mouse from a mouse

August 14, 2019
Tagged as: backcrossed, congenial, immune, immunology, inbred mice, laboratory mouse, RNA-seq

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Genetic variation in laboratory mice (Immunity) 11:02
Time stamps by Jolene. Thanks!
Vaccines and Your Child 1:09:11
Letters read on Immune 23 1:05:33

Weekly Science Picks 1:19:10

Steph – University of Alaska budget crisis
Cindy – 90% survival following new Ebolavirus treatments
Vincent – Immunology videos at Blausen Medical

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 22: Engineering B cells

July 31, 2019
Tagged as: allelic exclusion, antibody, B cell, CRISPR/Cas, heavy chain, immune, immunology, light chain, vaccine

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Engineering B cells to produce antiviral antibodies (Sci Immun) 5:45
Time stamps by Jolene. Thanks!
Letters read on Immune 22 4:18, 55:14

Weekly Science Picks 1:07:59

Steph – Breath of fresh air
Cindy – Biologist found dead
Vincent – Nobel Prizes and Nature’s Surprises by Erling Norrby

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 21: Islets of Langelhans

June 12, 2019
Tagged as: autoimmunity, B cells, BCR, dual expressing lymphocytes, immune, immunology, public BCR, T cells, TCR, type I diabetes

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Dual receptor lymphocytes and type I diabetes (Cell) 29:47
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:18:43

Steph – Unique Scientists
Cindy – Researcher app
Vincent – STLR Conversations Podcast

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Immune

Immune 20: In defense of death

May 29, 2019
Tagged as: blood clotting, gasdermin, immune, immunology, inflammasome, inflammation, pyroptosis, thrombosis, tissue factor

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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