Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Download TWiN 018  (43 MB .mp3, 71 min)
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Music is by Ronald Jenkees

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Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Michael Nitabach

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Download TWiN 017  (49 MB .mp3, 82 min)
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Music is by Ronald Jenkees

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Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.

Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung

Guest: Stefano Brigidi

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Download TWiN 016  (41 MB .mp3, 68 min)
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Music is by Ronald Jenkees

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Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

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Download TWiN 015  (30 MB .mp3, 50 min)
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Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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Download TWiN 014  (43 MB .mp3, 71 min)
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Music is by Ronald Jenkees

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Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Download TWiN 013  (41 MB .mp3, 68 min)
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Music is by Ronald Jenkees

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Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd

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Download TWiN 012  (44 MB .mp3, 73 min)
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Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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Download TWiN 011  (40 MB .mp3, 66 min)
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Music is by Ronald Jenkees

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TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Download TWiN 010  (40 MB .mp3, 67 min)
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  • IL-33 promotes synaptic plasticity (Cell) 4:51, 12:25
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

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Download TWiN 009  (40 MB .mp3, 67 min)
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Intro music is by Ronald Jenkees

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