TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Download TWiN 008  (43 MB .mp3, 71 min)
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Intro music is by Ronald Jenkees

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The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racaniello

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Download TWiN 007  (51 MB .mp3, 84 min)
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Intro music is by Ronald Jenkees

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Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, and Jason Shepherd

Guest: Nirao Shah

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Download TWiN 006 (38 MB .mp3, 64 min)
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Intro music is by Ronald Jenkees.

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Olfactory epithelium

Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello

Guest: Bob Datta

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Download TWiN 005 (36 MB .mp3, 59 min)
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Intro music is by Ronald Jenkees.

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Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.

Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello

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Download TWiN 004 (42 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees.

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Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.

Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello

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Download TWiN 003 (49 MB .mp3, 81 min)
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Intro music is by Ronald Jenkees.

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The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing.

Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent Racaniello

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Download TWiN 002 (52 MB .mp3, 86 min)
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Intro music is by Ronald Jenkees.

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The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Download TWiN 001 (27 MB .mp3, 43 min)
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Intro music is by Ronald Jenkees.

Send your neuroscience questions and comments to twin@microbe.tv