TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. 

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 050 (46 MB .mp3, 64 min)
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Music is by Ronald Jenkees

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TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. 

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Download TWiN 049 (66 MB .mp3, 91 min)
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Music is by Ronald Jenkees

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TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 048 (37 MB .mp3, 51 min)
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Music is by Ronald Jenkees

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TWiN reviews an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 047 (40 MB .mp3, 55 min)
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Music is by Ronald Jenkees

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TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 046 (37 MB .mp3, 51 min)
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Music is by Ronald Jenkees

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TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 045 (38 MB .mp3, 52 min)
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Music is by Ronald Jenkees

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TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 044 (44 MB .mp3, 61 min)
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Music is by Ronald Jenkees

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TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 043 (45 MB .mp3, 63 min)
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Music is by Ronald Jenkees

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TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 042 (34 MB .mp3, 57 min)
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Music is by Ronald Jenkees

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Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 041 (39 MB .mp3, 64 min)
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Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv