Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

Click arrow to play
Download TWiN 015  (30 MB .mp3, 50 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

Click arrow to play
Download TWiN 014  (43 MB .mp3, 71 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

Click arrow to play
Download TWiN 013  (41 MB .mp3, 68 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd

Click arrow to play
Download TWiN 012  (44 MB .mp3, 73 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

Click arrow to play
Download TWiN 011  (40 MB .mp3, 66 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

Click arrow to play
Download TWiN 010  (40 MB .mp3, 67 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

  • IL-33 promotes synaptic plasticity (Cell) 4:51, 12:25
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

Click arrow to play
Download TWiN 009  (40 MB .mp3, 67 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

Click arrow to play
Download TWiN 008  (43 MB .mp3, 71 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racaniello

Click arrow to play
Download TWiN 007  (51 MB .mp3, 84 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for the episode

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, and Jason Shepherd

Guest: Nirao Shah

Click arrow to play
Download TWiN 006 (38 MB .mp3, 64 min)
Subscribe (free): iTunesGoogle PodcastsRSS, email

Become a patron of TWiN!

Links for this episode

Intro music is by Ronald Jenkees.

Send your neuroscience questions and comments to twin@microbe.tv