TWiN 53: Slowing time by cooling the brain

Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Joseph J. Paton and Felipe Rodrigues

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Download TWiN 053 (50 MB .mp3, 70 min)
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Music is by Ronald Jenkees

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TWiN 52: Probiotic improves social behavior in children with ASD

Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.

Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Download TWiN 052 (47 MB .mp3, 66 min)
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Music is by Ronald Jenkees

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TWiN 51: Sensory processing dysfunction in autism spectrum disorders

TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. 

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 051 (51 MB .mp3, 71 min)
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Music is by Ronald Jenkees

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TWiN 50: Neurological sequelae after COVID-19

TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. 

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 050 (46 MB .mp3, 64 min)
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Music is by Ronald Jenkees

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TWiN 49: Mirror, mirror on the wall, who’s the fairest mouse of all?

TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. 

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Download TWiN 049 (66 MB .mp3, 91 min)
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Music is by Ronald Jenkees

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TWiN 48: Traumatic brain injury and retroviruses

TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 048 (37 MB .mp3, 51 min)
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Music is by Ronald Jenkees

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TWiN 47: Walking after spinal cord injury

TWiN reviews an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 047 (40 MB .mp3, 55 min)
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Music is by Ronald Jenkees

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TWiN 46: Neuronal activity promotes glioma progression

TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 046 (37 MB .mp3, 51 min)
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Music is by Ronald Jenkees

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TWiN 45: Acupuncture modulates the immune system

TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 045 (38 MB .mp3, 52 min)
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Music is by Ronald Jenkees

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TWiN 44: ADHD and persistent pain

TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 044 (44 MB .mp3, 61 min)
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Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv