Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.