TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression.
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin.
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain.
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.
