Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.
TWiN 36: Unbearable neurologists
- January 3, 2023
- Tagged as: Alzheimer's disease, brain, nervous system, neurobiology, neurology, neuron, neuroscience
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression.
TWiN 31: HIV-1 co-receptor shapes window for memory linking
- June 29, 2022
- Tagged as: CCR5, maraviroc, memory, memory linking, neurobiology, neuron, neuroscience
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.
TWiN 25: Thanks for listening
- December 28, 2021
- Tagged as: memory, neurology, neuron, neuroscience, odorant receptor, sex
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.
Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.
TWiN 14: Reducing Alzheimer-like pathology in mice
- January 14, 2021
- Tagged as: Alzheimer disease, amyloid beta, amyloid plaque, neurology, neuron, neuroscience
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.