Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast.