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Tag: neuron

  • This Week in Neuroscience

TWiN 36: Unbearable neurologists

  • January 3, 2023
  • Tagged as: Alzheimer's disease, brain, nervous system, neurobiology, neurology, neuron, neuroscience

TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.

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  • This Week in Neuroscience

TWiN 35: Neuromodulation in treatment-resistant depression

  • December 6, 2022
  • Tagged as: brain, close-loop neuromodulation, depression, major depressive disorder, nervous system, neurobiology, neurology, neuron, neuroscience, psychiatric disorder

Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. 

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  • This Week in Neuroscience

TWiN 31: HIV-1 co-receptor shapes window for memory linking

  • June 29, 2022
  • Tagged as: CCR5, maraviroc, memory, memory linking, neurobiology, neuron, neuroscience

TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.

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  • This Week in Neuroscience

TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson’s disease

  • May 24, 2022
  • Tagged as: alpha-synuclein, Braak hypothesis, Lewy body, neurobiology, neurodegenerative disease, neuron, neuroscience, vagus nerve

TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.

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  • This Week in Neuroscience

TWiN 25: Thanks for listening

  • December 28, 2021
  • Tagged as: memory, neurology, neuron, neuroscience, odorant receptor, sex

TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.

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  • This Week in Neuroscience

TWiN 16: Neuronal depolarization with Stefano Brigidi

  • March 17, 2021
  • Tagged as: astrocyte, memory, nervous system, neurology, neuron, neuronal depolarization, neuroscience, podcast, transcription factor NPAS4

Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.

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  • This Week in Neuroscience

TWiN 14: Reducing Alzheimer-like pathology in mice

  • January 14, 2021
  • Tagged as: Alzheimer disease, amyloid beta, amyloid plaque, neurology, neuron, neuroscience

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

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  • This Week in Neuroscience

TWiN 13: mRNAs for long-term memory

  • December 16, 2020
  • Tagged as: astrocyte, contextual fear memory, engrams, inflammation, learning, long-term memory, membrane fusion, memory, memory consolidation, microglia, neuron, neuroscience

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

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  • This Week in Neuroscience

TWiN 11: A dollar per neuron

  • October 14, 2020
  • Tagged as: astrocyte, brain cortex, evolution, interneuron, mammals, neuron, neuroscience, reptiles, single cell transcriptomics

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

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  • This Week in Neuroscience

TWiN 10: Remodeling synapses with a cytokine

  • September 29, 2020
  • Tagged as: cytokine, hippocampus, IL-33, microglia, neurology, neuron, neuronal circuit, neuroscience, spine plasticity, synapse remodeling

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

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