TWiN 20: Drifting aromas in the brain

While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 19: Glia 101

On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli

Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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TWiN 17: Worms see the light with Michael Nitabach

Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Michael Nitabach

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TWiN 16: Neuronal depolarization with Stefano Brigidi

Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.

Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung

Guest: Stefano Brigidi

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TWiN 15: Microbiome and neurodevelopment with Helen Vuong

Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

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TWiN 14: Reducing Alzheimer-like pathology in mice

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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TWiN 13: mRNAs for long-term memory

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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TWiN 12: A gene for short-term memory

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd

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TWiN 11: A dollar per neuron

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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Music is by Ronald Jenkees

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