TWiN 14: Reducing Alzheimer-like pathology in mice

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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Music is by Ronald Jenkees

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TWiN 13: mRNAs for long-term memory

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Music is by Ronald Jenkees

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TWiN 12: A gene for short-term memory

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd

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Music is by Ronald Jenkees

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TWiN 11: A dollar per neuron

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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TWiN 10: Remodeling synapses with a cytokine

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

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  • IL-33 promotes synaptic plasticity (Cell) 4:51, 12:25
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 9: COVID-19 neurology with Genna Waldman

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

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Intro music is by Ronald Jenkees

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TWiN 8: Replacing lost neurons

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiN 7: Stress, the good, bad and beautiful

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiN 6: Neural control of sexual behavior

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, and Jason Shepherd

Guest: Nirao Shah

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Intro music is by Ronald Jenkees.

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TWiN 5: Anosmia and COVID-19

Olfactory epithelium

Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello

Guest: Bob Datta

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Intro music is by Ronald Jenkees.

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