Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello
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Links for this episode
- Reducing Alzheimer-like pathology in mice (Nat Neurosci) 2:56, 25:43
- Letters read on TWiN 13 57:25
- Timestamps by Jolene. Thanks!
Music is by Ronald Jenkees
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I think this is the review of current therapeutics mentioned @ 24:30 mark: See Table 1
Long and Holtzman, Alzheimer Disease: An Update on Pathobiology and Treatment Strategies, Cell (2019),
https://doi.org/10.1016/j.cell.2019.09.001