This Week in Neuroscience

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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Download TWiN 014 (43 MB .mp3, 71 min)
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Reducing Alzheimer-like pathology in mice (Nat Neurosci) 2:56, 25:43
Letters read on TWiN 13 57:25
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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This Week in Neuroscience

TWiN 13: mRNAs for long-term memory

December 16, 2020
Tagged as: astrocyte, contextual fear memory, engrams, inflammation, learning, long-term memory, membrane fusion, memory, memory consolidation, microglia, neuron, neuroscience

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Transcriptional programs associated with long-term memory (Nature) 4:01
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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This Week in Neuroscience

TWiN 12: A gene for short-term memory

November 11, 2020
Tagged as: brain, collaborative cross mice, diversity outbred mice, nerve, neurology, neuroscience, orphan receptor, short term memory, spinal cord, thalamus, working memory

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd

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Thalamic orphan receptor in short term memory (Cell) 13:45
Anosmia in SARS-CoV-2 infected mice (Nature) 45:20
Letters read on TWiN 12 58:56
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

This Week in Neuroscience

TWiN 11: A dollar per neuron

October 14, 2020
Tagged as: astrocyte, brain cortex, evolution, interneuron, mammals, neuron, neuroscience, reptiles, single cell transcriptomics

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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Single-cell transcriptomics of reptile cortex (Science) 18:29
Innovations in primate interneurons (Nature) 9:09
Human versus mouse cortex (Nature) 43:55
Letters read on TWiN 11 55:12
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

This Week in Neuroscience

TWiN 10: Remodeling synapses with a cytokine

September 29, 2020
Tagged as: cytokine, hippocampus, IL-33, microglia, neurology, neuron, neuronal circuit, neuroscience, spine plasticity, synapse remodeling

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

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IL-33 promotes synaptic plasticity (Cell) 4:51, 12:25
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

This Week in Neuroscience

TWiN 9: COVID-19 neurology with Genna Waldman

August 11, 2020
Tagged as: cognitive defect, coma, COVID-19, hypoxia, neurobiology, neuroinvasion, neurological symptoms, neurology, neuropathology, neuroscience, pandemic, SARS-CoV-2, stroke, thrombosis

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

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Preparing a neurology department for COVID-19 (Neurology) 14:53
Managing comatose COVID-19 patients (Ann Neurol) 21:12
Neuropathology of COVID-19 (NEJM) 47:41
Letters read on TWiN 9 51:55
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

This Week in Neuroscience

TWiN 8: Replacing lost neurons

July 7, 2020
Tagged as: astrocytes, CRISPR, dopamine, gene editing, glial cells, neurology, neurons, neuroscience, neurotransmitter

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.