TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson’s disease

TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 29: Astrocytes close the critical period

TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 028 (44 MB .mp3, 74 min)
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Music is by Ronald Jenkees

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TWiN 28: Oligodendrocyte performance enhancing exosomes

TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 27: Eyes wired to the auditory cortex

TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.

Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 26: Immunological memory in the brain

TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 026 (75 MB .mp3, 63 min)
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Music is by Ronald Jenkees

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TWiN 25: Thanks for listening

TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke

Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin.

Hosts: Vincent Racaniello and Timothy Cheung

Guests: Ioana Carcea and Robert Froemke

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Music is by Ronald Jenkees

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TWiN 23: Peripheral nervous system with Bruce Carter

Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

Guest: Bruce Carter

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Download TWiN 023  (41 MB .mp3, 68 min)
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Music is by Ronald Jenkees

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TWiN 22: It’s never lupus

TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 21: How do we know if a mouse is hallucinating?

TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.

Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung

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Download TWiN 021  (53 MB .mp3, 88 min)
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Music is by Ronald Jenkees

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