TWiN 39: Virus-like capsids trigger paraneoplastic disease

Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu

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Download TWiN 039 (39 MB .mp3, 65 min)
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Music is by Ronald Jenkees

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TWiN 38: Bacterial immunity heals sensory neurons

TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.

Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Download TWiN 038 (39 MB .mp3, 65 min)
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Music is by Ronald Jenkees

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TWiN 37: Microglia at the crossroads

TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 036 (45 MB .mp3, 75 min)
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Music is by Ronald Jenkees

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TWiN 36: Unbearable neurologists

TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 036 (35 MB .mp3, 58 min)
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Music is by Ronald Jenkees

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TWiN 35: Neuromodulation in treatment-resistant depression

Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. 

Hosts: Jason Shepherd and Timothy Cheung

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Download TWiN 035 (35 MB .mp3, 58 min)
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  • Closed-loop neuromodulation for depression (Nat Med) 2:37, 32:15
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 34: Microglia vital after spinal cord injury

TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 034 (35 MB .mp3, 58 min)
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Music is by Ronald Jenkees

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TWiN 33: Viruses leaving the brain

TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung

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Download TWiN 033 (35 MB .mp3, 58 min)
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Music is by Ronald Jenkees

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TWiN 32: Relearning how to move after stroke

TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.

Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Download TWiN 032 (36 MB .mp3, 60 min)
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Music is by Ronald Jenkees

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TWiN 31: HIV-1 co-receptor shapes window for memory linking

TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 031 (43 MB .mp3, 72 min)
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Music is by Ronald Jenkees

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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson’s disease

TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Download TWiN 030 (44 MB .mp3, 74 min)
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Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv