Immune - Part 7

Immune

Immune 18: Biting off more TCR than you can chew

March 27, 2019
Tagged as: immune, immunology, MHC I, MHC II, peptide, T cell receptor, trogocytosis

The immunophiles discuss T cell antigen discovery by trogocytosis – the transfer of membrane patches among cells in close contact.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Trogocytosis for T cell antigen discovery (Nat Methods) 25:02
Trogocytosis (J Immunol)
Orphan T cell receptors (Cell)
Trogocytosis video (YouTube) 17:21
Image credit
Letters read on Immune 18 1:01:50
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:07:15

Steph – Scientists rise up against statistical significance
Cindy – Why I quit my PhD and returned
Vincent – The Law and Vaccine Resistance

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 17: Feed a macrophage, starve a tumor

February 13, 2019
Tagged as: cancer, CD47, CpG, glycolysis, immune, immunology, Krebs cycle, Tlr9, tumor

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Darwin Day 1:17
Metabolic rewiring of macrophages by CpG (Nat Immunol) 2:27, 26:39
Letters read on Immune 17 52:52
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:01:30

Steph – Pregnant Scholar
Cindy – Anti-vaxxers vaccinating against measles
Vincent – Center for Science in the Public Interest

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 16: B is for Bursa

January 19, 2019
Tagged as: B cells, Bursa, gene knockout, herpesvirus, immune, immunology, Marek's disease, pathogenesis

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek’s disease herpesvirus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Role of B cells in Marek’s disease pathogenesis (PNAS) 5:09
In ovo vaccination (YouTube) 11:47
First chickens lacking B cells (PNAS) 19:00
Letters read on Immune 16 45:30
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:01:20

Steph – 7 Days Out
Cindy – Watson PBS documentary and Cold Spring Harbor Laboratory response
Vincent – Dads can donate mitochondrial DNA and Chicken puns

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 15: Happy neu-trophil year

December 22, 2018
Tagged as: diapedesis, immune, immunology, leukocyte, neutrophil, neutrophil net, neutrophil rolling, tether and sling

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Slings enable neutrophil rolling (Nature) 33:20
Sling video (La Jolla Inst Allergy Immunol) 32:43
Neutrophil extracellular traps kill bacteria (Science) 50:45
Neutrophil review (Sci Immunol)
Image credit
Letters read on Immune 15 1:04:06
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:14:01

Steph – Should reviewers remain anonymous?
Cindy – Breast Cancer Research Foundation
Vincent – Initiative to End Paywalls (The Scientist)

Listener Pick

Jim – Eat to Live (YouTube)

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 14: Braking bad

November 14, 2018
Tagged as: cancer immunotherapy, CTLA-4, immune, immune checkpoint inhibitor, immunology, immunotherapy, James Allison Tasuku Honjo, Nobel Prize, PD-1, PDL-1, T cell

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

2018 Nobel Prize in Medicine 5:53
2018 Nobel Prize in Medicine (pdf)
What’s in a name? (Can Res Inst) 38:19
Checkpoint inhibitor failures (Nature) 1:03:06
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:13:25

Steph – Immunobites
Cindy – List of immunology Nobels
Vincent – Prof. Barker’s Immunology lectures

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 13: Do no harm

October 20, 2018
Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;amp;amp;gt;

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Links for this episode

Host lncRNA binds RIG-I (Cell) 18:16
Microbe Art at virology blog 1:09:40
Letters read on Immune 13 50:59
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:07:18

Steph – That’s Pediatrics Podcast
Cindy – Trilobite Glassworks
Vincent – Research!America

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 12: Systems immunology

September 19, 2018
Tagged as: cell sorting, cord blood, CyTOF, FACS, immune, immune system, immunology, microbiome, newborn children, postnatal immunity, RNAseq, systems immunology

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

Immune system development in newborns (Cell) 25:15
Dead parrots and live wildcats (TWiV 185) 1:00:35
Pathogenesis card game (JAMA) 1:04:06
Letters read on Immune 12 55:33

Weekly Science Picks 1:04:07

Steph – Kaleidoscopean
Cindy – 500 women scientists
Vincent – NIH budget increase 2019

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 11: Immunomimetic designer cells

August 18, 2018
Tagged as: biofilm, gene network, immune, immunology, immunomimetic, implant infection, inflammation, innate immune response, lysostaphin, MRSA, Staphylococcus aureus

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.

Hosts: Vincent Racaniello and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Links for this episode

Immunomimetic designer cells (Cell) 1:58, 26:46
Antimicrobial drug resistance (NIH) 4:40, 13:51
Image credit 36:45
Letters read on Immune 11 46:59

Science Picks 1:01:59

Cindy – No Tdap link to autism
Vincent – Unpaywall

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 10: Immune goes viral

July 21, 2018
Tagged as: antibodies, antibody escape mutants, broadly neutralizing antibodies, HIV-1, immune, immunology, Rebecca Lynch

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Rebecca Lynch

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 9: Neither mice nor lamprey lie

June 20, 2018
Tagged as: antibodies, hagfish, immune, immunity, immunoglobulins, jawed vertebrates, jawless vertebrates, lamprey, leucine rich repeat, variable lymphocyte receptor, VLR

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;gt;&amp;lt;/span&amp;gt;&amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;gt;&amp;amp;lt;/span&amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;gt;&amp;amp;amp;lt;/span&amp;amp;amp;gt;&amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;lt;/span&amp;amp;amp;amp;amp;gt;

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Lamprey VLR response to influenza virus (eLife) 34:14
VLR-based immunity (Ann Rev Immunol)
How the Immune System Works 1:13:11
A Commotion in the Blood 1:13:35
Immune merchandise 1:05:34
Image credit 34:53
Letters read on Immune 9 51:27

Weekly Science Picks 1:20:05

Steph – Jon Yewdell on TWiV (208, 467)
Cindy – No polio in Venezuela
Vincent – Is gaming addiction a thing?

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

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