In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Download TWiV 528 (77 MB .mp3, 128 min)
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Links for this episode
- Please take the TWiV listener survey 4:40
- ASV 2019 Satellite Symposia
- Crowdfunding for EV-D68 research 10:37
- TWiV World Tour 2018 t-shirt (Amazon) 20:58
- Cool virology from 2018 22:42
- Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two 22:52
- Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program 27:53
- Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 32:43
- Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 35:47
- Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 40:42
- Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 52:49
- Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraine and Europe 59:54
- Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 1:07:20
- Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 1:09:32
- Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 1:16:32
- Image credit
- Letters read on TWiV 528 1:25:14
- Timestamps by Jolene. Thanks!
Weekly Science Picks 1:39:10
Alan – Pandemic Trail game
Rich – On a Bat’s Wing and a Prayer
Dickson – Decoding Watson
Kathy – Phenotypic variation in outbred and inbred mice
Vincent – Trump County Confronts the Administration Amid Rash of Child Cancers
Listener Pick
Anne – Peter Hotez interview
Islam – Letter from Crick to Watson (pdf)
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Prof. V
Happy New Year and Belated Birthday to us!!!!!
Johnye Ballenger
PS I check rhododendron leaves as well for a qualitative temp reading. Currently, -3 C in Boston.
Wow, I complete the TWiV listener survey asking for a review/retrospective/overview of RNA, and what do I find?
You folks are psychic too! Who could ask for anything more? Well, maybe an immortalized TWiV podcast cell line.
Thank you.
Johnye
Vincent, You are Route 66 and a sexagenarian! Enjoy.
Johnye, also a Jan 2 birth person.
Sorry about all the comments tonight.
Realized it was the evolutionary hx of RNA viruses, not RNAs. Oh well.
Abstract
Little is known about the origin and long-term evolutionary mode of retroviruses. Retroviruses can integrate into their hosts’ genomes, providing a molecular fossil record for studying their deep history. Here we report the discovery of an endogenous foamy virus-like element, which we designate ‘coelacanth endogenous foamy-like virus’ (CoeEFV), within the genome of the coelacanth (Latimeria chalumnae). Phylogenetic analyses place CoeEFV basal to all known foamy viruses, strongly suggesting an ancient ocean origin of this major retroviral lineage, which had previously been known to infect only land mammals. The discovery of CoeEFV reveals the presence of foamy-like viruses in species outside the Mammalia. We show that foamy-like viruses have likely codiverged with their vertebrate hosts for more than 407 million years and underwent an evolutionary transition from water to land with their vertebrate hosts. These findings suggest an ancient marine origin of retroviruses and have important implications in understanding foamy virus biology.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002790