TWiV 519: Fishing for viruses in senile

The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Download TWiV 519 (58 MB .mp3, 96 min)
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Links for this episode

• Virology Comics on sale (Amazon) 5:06
• Clinical Trial: antiviral for AD 5:30
• HHV6 and HHV7 transcripts in AD brain (TWiV 505) 14:46
• HSV1 in AD (Front Ag Neuro) 15:52
• Taiwan cohort study on antivirals and AD (Neurother) 25:47
• HSV1 antibodies in CSF (J Med Virol) 38:04
• HSV1 induces amyloid-beta fibrillization (Neuron) 54:36
• Image credit
• Letters read on TWiV 519 32:25, 1:05:28
• Timestamps by Jolene. Thanks!

Weekly Science Picks 1:17:24

Brianne – Pandemic (board game)
Alan – The Shortwave Radio Audio Archive (site and blog)
Rich – James Cook’s First Pacific Voyage, 1768-1771 (interactive map)
Dickson – The Scientist on Instagram
Vincent – State of the World’s Fungi

Listener Pick

David – Bruno LaTour

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv