Immune - Part 8

Immune

Immune 31: Immunology of COVID-19, part three

May 8, 2020
Tagged as: antibody, BCG, COVID-19, immune, immunology, OPV, SARS-CoV-2, vaccine

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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How long will a vaccine really take? (NYTimes) 37:15
Humoral immunity in NYC COVID-19 patients (medRxiv) 43:13
D614G is just a SNP (TWiEVO 55) 32:54
Letters read on Immune 31 37:15
Image credit
Transcript of this episode (html, pdf)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 30: Immunology of COVID-19, part two

April 17, 2020
Tagged as: antibody, coagulation, coronavirus, COVID-19, cytokine storm, IL6, immune, immunology, SARS-CoV-2, steroids

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 29: Immunology of COVID-19

March 31, 2020
Tagged as: coronavirus, COVID-19, immune, immunology, immunopathology, pandemic, SARS-CoV-2, viral, virology, virus

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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ACE2 in oral mucosa (I J Oral Sci) 13:32
IL6 predictor of COVID-19 death (Int Care Med) 41:38
Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) 1:19:18
Antibody to SARS-CoV wanes (J Immunol)
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 28: Fish immunology

February 8, 2020
Tagged as: IgT, immune, immunology, microbiome, mucosal antibody, pathogen control, rainbow trout, teleost

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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Evolution of mucosal Ig in rainbow trout (Sci Immunol) 19:12
Fish olfactory neurons mediate rapid immune response (PNAS) 39:32
Image credit
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 27: Trained immunity

January 11, 2020
Tagged as: enhancer, H3K4Me1, immune, immune memory, immunology, innate immunity, LPS, methylation, NK cells, sepsis

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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H3K4me1 mark on memory-like NK cells (Cell Rep) 14:42
Letters read on Immune 27 1:08:37
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:22:07

Steph – Rotavirus & polio vaccines should be separated (article, paper)
Cindy – Diversify Immunology
Vincent – No winter break from publish or perish

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 26: Measles erases immune memory

November 28, 2019
Tagged as: immune, immunology, immunosuppression, lymphocytes, measles virus, MMR vaccine, plasma cells, viral, VirScan, virus

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

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Measles virus infection diminishes pre-existing antibodies (Science) 21:33
Public epitope #1 (TWiV 342) 33:12, 1:11:35
Incomplete reconstitution of B cell pools after measles (Sci Immunol) 1:14:15, 1:21:59
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 25: Remembrance of antigen encounters past

November 1, 2019
Tagged as: antigen presentation, CD8+ T cells, glycolysis, high fiber diet, immune, immunology, microbiome, oxidative phosphorylation, short chain fatty acids, T cell memory, TCA cycle

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Download Immune 25 (50 MB .mp3, 82 min)
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