Immune - Part 7

Immune

Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box

March 24, 2021
Tagged as: cancer, CAR-MAC, CAR-NK, CAR-T cell therapy, immune, immunology, macrophage, NK cell, tumor

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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CAR-T cell therapy on Immune 4 7:48
Recent CAR-T cell advances (Nat Rev Cancer)
Status of CAR-T cell therapy (CancerConnect)
CAR-MAC for cancer (Nat Biotech) 48:37
CAR-MAC for COVID-19 (bioRxiv) 1:04:06
Letters read on Immune 43 1:08:34
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler

February 13, 2021
Tagged as: antibody, B cells, coronavirus, COVID-19, immune, immunology, memory B cells, pandemic, SARS-CoV-2

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Christian Gaebler

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Download Immune 42 (43 MB .mp3, 71 min)
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Evolution of antibody immunity to SARS-CoV-2 (Nature) 10:18
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 41: Zebrafish immunology with Madina Wane

January 25, 2021
Tagged as: anosmia, COVID-19, fish, gills, immune, immunology, pandemic, SARS-CoV-2, zebrafish

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Madina Wane

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Download Immune 41 (50 MB .mp3, 93 min)
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Black in Immuno (YouTube) 9:39
Cytokines and gill homeostasis (J Immune) 1:16:44
Zebrafish model of COVID-19 olfactory loss (bioRxiv) 32:00
Overview of fish vaccination (pdf)
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 40: COVID-19 nuances

December 30, 2020
Tagged as: antibody, coronavirus, COVID-19, immune, immunity, immunology, pandemic, SARS-CoV-2, T cell, T cell exhaustion, vaccine

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 40 (57 MB .mp3, 95 min)
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Immune response during common cold CoV infection (Epidem Infect) 53:26
Summary of diagnostic tests (NAS) 1:27:06
Letters read on Immune 40 47:59
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 39: A Tonka Truck full of salt

December 1, 2020
Tagged as: coronavirus, COVID-19, cross reactive memory, immune, immunodominant epitopes, immunology, long-term COVID, mucosal surface, pandemic, peptide megapolis, SARS-CoV-2, T cell epitopes, T cell receptor

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Reflections of a COVID-19 long hauler (JAMA) 4:27
Not a cytokine storm in COVID-19 (JCIO) 56:52
Letters read on Immune 39 2:41
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 38: COVID-19 and kids with Sallie Permar

November 28, 2020
Tagged as: CMV, COVID-19, HIV/AIDS, immune, immunology, mother to child transmission, mucosal immunity, pandemic, SARS-CoV-2, vaccine

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Sallie Permar

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Download Immune 38 (43 MB .mp3, 71 min)
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Immune correlates of protection against CMV (J Inf Dis) 32:36, 36:35
Placental IgG transfer in HIV-1-infected women (Cell) 34:53
Immunization leads to HIV-1 antibody in breast milk (J Virology) 31:38
Lessons from COVID-19 in children (Clin Inf Dis) 46:51
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 37: Black in Immuno

November 16, 2020
Tagged as: black in immune, Black voices in immunology, dendritic cell, diversity, immune, immunology, macrophage, NK cell, systemic racism, T cell

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean

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Black in Immuno 3:59, 1:28:30, 1:31:03
Black in Immuno week schedule 1:29:10
Systemic racism in higher education (Science)
Black in Microbiology (TWiM 228) 1:56:08
Black in Virology (TWiV 672) 1:56:09
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 36: Aberrant immunity in COVID-19

October 21, 2020
Tagged as: antibody, coronavirus, COVID-19, germinal center, herd immunity, humoral immunity, immune, immune memory, immunology, pandemic, SARS-CoV-2, somatic hypermutation

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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Download Immune 36 (53 MB .mp3, 88 min)
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Links for this episode

Loss of germinal centers in severe COVID-19 patients (Cell) 11:01
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 35: SARS-CoV-2 antibodies

September 23, 2020
Tagged as: antibodies, coronavirus, correlates of protection, COVID-19, immune, immunology, pandemic, SARS-CoV-2, spike protein

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 35 (48 MB .mp3, 80 min)
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Links for this episode

COVID-19 severity linked to antibody levels (bioRxiv) 7:12
Review of antibody mediated immunity to coronaviruses (Nat Comm) 45:51
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune

Immune 34: Coronavirus cross-reacting T cells

August 25, 2020
Tagged as: CD4 T cell, coronavirus, COVID-19, epitope, MHC molecule, pandemic, peptide, SARS-CoV-2, T cell, T cell epitope, T cell receptor, viral, virology, virus, viruses

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 34 (52 MB .mp3, 87 min)
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Links for this episode

Cross-reactive coronavirus CD4+ T cells (Science) 5:46
Immune misfiring in severe COVID-19 (Nature) 50:05
A COVID-19 riddle for the immune system (Nature) 52:06
Letters read on Immune 34 59:57
Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

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Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box

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Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler

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Immune 41: Zebrafish immunology with Madina Wane

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Immune 40: COVID-19 nuances

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Immune 39: A Tonka Truck full of salt

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Immune 38: COVID-19 and kids with Sallie Permar

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Immune 37: Black in Immuno

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Immune 36: Aberrant immunity in COVID-19

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Immune 35: SARS-CoV-2 antibodies

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Immune 34: Coronavirus cross-reacting T cells

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