TWiV 135: Live in the Big Easy

ASM GM New OrleansHosts: Vincent Racaniello, Roger Hendrix, Rachel Katzenellenbogen, and Harmit Malik

Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.

Click the arrow above to play, or right-click to download TWiV #135 (63 MB .mp3, 97 minutes).

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Weekly Science Picks

Roger – Atomic structure of adenovirus by cry0-EM (Science)
Harmit – Syncytin knockout mice show role for endogenous retroviral gene (PNAS)
 Vincent – Free science, one paper at a time by David Dobbs

Listener Pick of the Week

Mark  – Shot by Shot

Send your virology questions and comments to [email protected].

TWiV 134: Meet Ralph, your cruise director

norovirusHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Stephanie Karst

Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.

Click the arrow above to play, or right-click to download TWiV #134 (68 MB .mp3, 94 minutes).

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Weekly Science Picks

Stephanie – Effectors of the type I interferon response (Nature)
Dickson – Receptor for Ebola virus (PNAS)
Rich – A History of Vaccines
Alan – The Worst Journey in the World by Apsley Cherry-Garrard
Vincent – ASM Live 2011 webcast

Listener Pick of the Week

Sophie  – TED talk app for iPad and iPhone

Send your virology questions and comments to [email protected].

TWiV 133: The HIV hideout

Dr. Kathleen CollinsHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathleen Collins

Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.

Click the arrow above to play, or right-click to download TWiV #133 (42 MB .mp3, 87 minutes).

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Weekly Science Picks

Kathleen – TRIM5 is an innate immune sensor (Nature)
Rich – A Biologist’s Mothers Day Song (YouTube)
Alan – World of Viruses
Vincent – Magnet Balls (Amazon)

Listener Pick of the Week

Chris  – Periodic Tales by Hugh Aldersey-Williams

Send your virology questions and comments to [email protected].

TWiV 132: Virology 911

alfred sacchettiHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Alfred Sacchetti

Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.

Click the arrow above to play, or right-click to download TWiV #132 (48 MB .mp3, 100 minutes).

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Links for this episode:

Weekly Science Picks

Al – The Physics of Superheroes and NKT Watch
Dickson – Fibonacci Fun by Trudi Hammel Garland and Rachel Gage
Rich – Retraction Watch
Alan – Neil deGrasse’s comments on UFOs, argument from ignorance, and scientific method (YouTube)
Destanie – Microcosm by Carl Zimmer
Vincent – The intestinal microbiota and viral susceptibility

Listener Pick of the Week

Jim  – Extraordinary Measures

Send your virology questions and comments to [email protected].

TWiV 131: A REOstat for cancer

reovirus coreHosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Brad Thompson

Vincent, Alan, and Dickson chat with Brad Thompson, CEO of Oncolytics Biotech, about using reovirus to treat cancer.

Click the arrow above to play, or right-click to download TWiV #131 (42 MB .mp3, 97 minutes).

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Links for this episode:

Weekly Science Picks

Dickson – Angels and Insects
Alan – Science Buddies
Vincent – Emerging Diseases: The Importance of Early Warning and Surveillance (YouTube)

Listener Pick of the Week

Josh  – Prof. Racaniello’s Virology course on iTunes

Send your virology questions and comments to [email protected].

TWiV 130: Rhino tracking, wrestling pox, and HCV in the crosshairs

organ culture hrv cHosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication.

Click the arrow above to play, or right-click to download TWiV #130 (45 MB .mp3, 93 minutes).

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Links for this episode:

Weekly Science Picks

Rich – Rock-paper-scissors vs computer (thanks, Megan!)
Alan – WebCite
Vincent – Edward Jenner Museum (EID)

Listener Pick of the Week

Derek Tolly  – A Paralyzing Fear: The Story of Polio in America (IMDb)

Send your virology questions and comments to [email protected].

TWiV 129: We’ve got mail

rich unwindsHosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.

Click the arrow above to play, or right-click to download TWiV #129 (67 MB .mp3, 93 minutes).

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Links for this episode:

Weekly Science Picks

Rich – Polyxeni Potter and EID covers
Dickson – American Museum of Natural History
Alan – Moon Trees (EurekAlert! article)
Vincent – Infection Landscapes

Listener Picks of the Week

Didier  – The Vaccines (MySpace)
/Sven-Urban – The Science of Discworld by Terry Pratchett
Garren – Omega Tau podcast

Send your virology questions and comments to [email protected].

TWiV 128: Virologists in the mist

gorillaHosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Welkin Johnson

Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.

Click the arrow above to play, or right-click to download TWiV #128 (67 MB .mp3, 92 minutes).

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Links for this episode:

Weekly Science Picks

Welkin – Walter Reed Collection, University of Virginia
Dickson – Bacteria-phage antagonistic coevolution in soil (Science)
Alan – The Artful Amoeba
Vincent – Potential bacteriophage applications (Microbe)

Send your virology questions and commentsto [email protected].

TWiV 127: Viruses are no joke

cold chainHosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.

Click the arrow above to play, or right-click to download TWiV #127 (62 MB .mp3, 86 minutes).

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Links for this episode:

Weekly Science Picks

Rich – Should smallpox be destroyed? (Emerging Infectious Diseases)
Alan – Zoology of the Beagle images
Vincent – Vaccines and Your Child by Paul Offit and Charlotte Moser

Send your virology questions and comments to [email protected].

TWiV 126: Wart’s up, doc?

michelle ozbunHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Michelle Ozbun

Virologist Michelle Ozbun and the TWiV team review the biology of human papillomaviruses.

Click the arrow above to play, or right-click to download TWiV #126 (69 MB .mp3, 96 minutes).

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Links for this episode:

Weekly Science Picks

Michelle – HIV-1 utilizes chemokine receptor CXCR4 to enter stem cells (PubMed)
Dickson – Bengladesh bans sale of palm sap (NY Times)
Rich – The Medusa and the Snail by Lewis Thomas (“On Warts” – pdf)
Alan – Planting Science – students, teachers, and scientists collaborate on botany experiments
Vincent – CIDRAP – Center for Disease Research and Policy

Send your virology questions and comments to [email protected].

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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