TWiV 145: The inVinceable TWiV

twortHosts: Alan Dove and Rich Condit

Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.

Click the arrow above to play, or right-click to download TWiV 145 (63 MB .mp3, 87 minutes).

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Links for this episode:

Weekly Science Picks

Alan – AT&T Tech Channel
Rich – Smallpox and its eradication (pdf)

Listener Pick of the Week

Asif – Science Photo Library

Send your virology questions and comments to [email protected].

TWiV 144: HIV gets the (zinc) finger

zinc finger nucleaseHosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.

Click the arrow above to play, or right-click to download TWiV 144 (75 MB .mp3, 104 minutes).

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Links for this episode:

Weekly Science Picks

Alan – Bugscope
Rich – Vaccine adverse events: Causal or coincidental? (Lancet)
 Vincent – West Nile Story by Dickson Despommier (Kindle edition)

Send your virology questions and comments to [email protected].

TWiV 143: Live at ASV in Minneapolis

asv minneapolisHosts: Vincent Racaniello, Rich Condit, Julie Overbaugh, and Stacey Schultz-Cherry

Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.

Click the arrow above to play, or right-click to download TWiV 143 (48 MB .mp3, 66 minutes).

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Links for this episode:

Weekly Science Picks

Rich – Iter – building a fusion reactor
 Vincent – American girls sweep at Google science fair (NY Times)

Listener Pick of the Week

Jing – Bees by Rudolph Steiner

Send your virology questions and comments [email protected].

TWiV 142: Viral oinkotherapy

seneca valley virusHosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.

Click the arrow above to play, or right-click to download TWiV 142 (69 MB .mp3, 95 minutes).

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Links for this episode:

Weekly Science Picks

Alan – Germlines podcast
Rich – science360
 Vincent – Google+

Listener Pick of the Week

Angus – Science Weekly with Alok Jha

Send your virology questions and comments to [email protected].

TWiV 141: Mickey gets HCV

hcv miceHosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Matt Evans

Matt Evans joins Vincent, Rich, Dickson, and Alan to deconstruct a mouse model for hepatitis C virus infection.

Click the arrow above to play, or right-click to download TWiV #141 (117 MB .mp3, 97 minutes).

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Links for this episode:

Weekly Science Picks

Matt – Benezra letter to NIH (pdf); (NIH response and Nature commentary)
Dickson – The Big Thirst by Charles Fishman
Alan – Earth’s First Steps by Jerry MacDonald
Rich – Final space shuttle launch and NIAID paylines
 Vincent – Hertog Global Strategy Initiative

Send your virology questions and comments to [email protected].

TWiV 140: An aptitude for microbicides

cd4 aptamer

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

Click the arrow above to play, or right-click to download TWiV #140 (110 MB .mp3, 92 minutes).

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Links for this episode:

Weekly Science Picks

Alan – Inside insides
Rich – Rock stars of science
 Vincent – A new open-access journal, and Francis Collins on NIH budget

Listener Pick of the Week

Kathy – Scientists and musicians compare notes (NPR)

Send your virology questions and comments to [email protected].

TWiV 139: Honey, I shrunk the virus

mimivirusHosts: Vincent Racaniello, Alan Dove, and Dickson Despommier

Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.

Click the arrow above to play, or right-click to download TWiV #139 (96 MB .mp3, 80 minutes).

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Links for this episode:

Weekly Science Picks

Alan – Life Before the Dinosaurs by ABC
Dickson – Inside Jokes by Matthew M. Hurley
 Vincent – The Tree of Life by Jonathan Eisen

Listener Pick of the Week

Lance – A History of the World since 9/11 by Dominic Streatfeild

Send your virology questions and comments to [email protected].

TWiV 138: RISCy business with Raul Andino

Drosophila melanogasterHosts: Vincent Racaniello and Raul Andino

Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.

Click the arrow above to play, or right-click to download TWiV #138 (53 MB .mp3, 73 minutes).

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Send your virology questions and comments to [email protected].

TWiV 137: Look what the dog dragged in

dog_humanHosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Amit Kapoor, and Ian Lipkin

The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.

Click the arrow above to play, or right-click to download TWiV #137 (69 MB .mp3, 96 minutes).

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Links for this episode:

Weekly Science Picks

Alan – What do marine mammals eat? (YouTube)
Rich – NIH rocket boys
Dickson – Cytomegalovirus needs an antiviral protein (Science)
 Vincent – All pdfs free at National Academy of Science Press

Listener Pick of the Week

Adriana and Ye Jung  – The man who was cured of AIDS (article one and two)

Send your virology questions and comments to [email protected].

TWiV 136: Exit XMRV

nude mouseHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Stephen Goff

Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.

Click the arrow above to play, or right-click to download TWiV #136 (61 MB .mp3, 84 minutes).

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Links for this episode:

Weekly Science Picks

Alan – The Demon-Haunted World by Carl Sagan
Rich – Trends in annual rates of death (pdf)
Stephen – Unexpected inheritance (PLoS Pathogens)
 Vincent – Beyond the human eye

Listener Pick of the Week

Raihan  – Bruce Aylward: How we’ll stop polio for good (YouTube)

Send your virology questions and comments to [email protected].

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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