Hosts: Vincent Racaniello and Kathy Spindler
Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.
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Links for this episode:
- Celsius vs Centigrade
- Neuropathogenesis during polymicrobial infection (PLoS Pathogens)
- Tetramer staining (pdf)
- One
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- Letters read on TWiV 172
Weekly Science Picks
Kathy – Science prize for inquiry-based instruction (Alberts editorial, second winner)
Vincent – The long and winding road to a Ph.D.
Listener Pick of the Week
Greg – Correlation
Send your virology questions and comments to twiv@microbe.tv.
Great pick of the week vinc!
Very interesting point about mumps, one I don’t think I’ve seen anyone consider in the literature. We’ve always really come at it from the point of the virus as some strains are thought to be more neurovirulent than others but nobody is really certain as to why this is the case. The virus certainly has no trouble entering your CNS – the figure of 50% you quoted is probably the upper limit though (lower limit is 4%). But lots of other people have gone back and tried to repeat that work buts it’s very difficult to do a lumbar puncture on children for something like mumps so it could even be an underestimate.
These adverse events (meningitis [<15%] and encephalitis [<0.5%]) usual happen in adults more so than kids and more often in males than females. So if it were to have a 'polymicrobial' aspect it would have to take into consideration these points. I'm all for trying it though!
very informative from one who lives with ME Thanks
“I have it in my car, my dashboard set on Celsius and it drives everybody crazy.”
I have my car set to Celsius too. What are the alternatives? Kelvin?
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(Just a euro-centric joke of mine…
Which reminds me:
Professor: “… and the temperature on the sun is 1 Million degrees.”
Student: “Celsius or Kelvin?”)
If I could set the car dash readout to Kelvin I would, just to drive everyone even more crazy.