TWiV 165: The email zone

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

Click the arrow above to play, or right-click to download TWiV 165 (61 MB .mp3, 102 minutes).

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Links for this episode:

Weekly Science Picks

Dickson – Creation
Rich – America’s Science Decline
Alan – Out of context science
Vincent – The Scientist Top 10 Innovations 2011

Listener Pick of the Week

Jim – Christoph Adami: Finding life we can’t imagine (TED)
Tim – Patient Zero (Radiolab)
Mary – Natural Obsessions by Natalie Angier
Jimmy – Science Exchange

Send your virology questions and comments to [email protected].

TWiV 164: Six steps forward, four steps back

xmrvHosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

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Ten virology stories of 2011:

  1. XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
  2. Influenza H5N1, ferrets, and the NSABB (TWiV 159)
  3. The Panic Virus (TWiV 117)
  4. Polio eradication (TWiV 127, 149)
  5. Viral oncotherapy (TWiV 124, 131, 142, 156)
  6. Hepatitis C virus (TWiV 130, 137, 141)
  7. Zinc finger nuclease and HIV therapy (TWiV 144)
  8. Bacteria help viruses (TWiV 154)
  9. Human papillomaviruses (TWiV 126)
  10. Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

Weekly Science Picks

Rich – Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

Send your virology questions and comments to [email protected].

TWiV 163: What Rous wrought

fungal christmas treeHosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

Click the arrow above to play, or right-click to download TWiV 163 (61 MB .mp3, 102 minutes).

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Links for this episode:

Weekly Science Picks

Rich – The Log from the Sea of Cortez by John Steinbeck
Alan – Comet rise
Vincent – TWiV iPhone case

Listener Pick of the Week

Ronnie – How fungi celebrate Christmas
Kevin – EcoCyc app
Gabriel – ImmGen app

Send your virology questions and comments to [email protected].

TWiV 162: Transcription

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.



Click the arrow above to play, or right-click to download TWiV 162 (56 MB .mp3, 93 minutes).

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Links for this episode:

Weekly Science Picks

Rich – 3D vaccinia virion
Alan – Happy Holidays from NOAA (YouTube)
Vincent – 17 year old wins $100,000 science prize

Listener Pick of the Week

Sarah – Critical Thinking (pdf),  diagnosing respiratory infections by gene signature (Cell Host Micro), and One Health Initiative (CDC page)

Send your virology questions and comments to [email protected].

transcription

TWiV 161: Concerto in B

antibodyHosts: Vincent Racaniello, Rich Condit, Alan Dove, and Gabriel Victora

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

Click the arrow above to play, or right-click to download TWiV 161 (71 MB .mp3, 118 minutes).

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Links for this episode:

Weekly Science Picks

Gabriel – Antibody-based protection against HIV (Nature)
Rich – Contact
Alan – Flu shot dystonia (YouTube)
Vincent – Sciflies and RocketHub

Listener Pick of the Week

Neva – Virus and retrovirus
Ayesha – The Life Scientific (BBC)

Send your virology questions and comments to [email protected].

TWiV 160: Moore tumor viruses

merkel carcinomaHosts: Vincent Racaniello, Rich Condit, Alan Dove, Dickson Despommier, and Patrick Moore

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi’s sarcoma herpesvirus and Merkel cell polyomavirus.

Click the arrow above to play, or right-click to download TWiV 160 (66 MB .mp3, 109 minutes).

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Links for this episode:

Weekly Science Picks

Patrick – The Theory That Would Not Die by Sharon Bertsch McGrayne
Dickson – Foodborne illness acquired in the US (Emerging Inf Dis)
Rich – GATTACA
Alan – Cutting for Stone by Abraham Verghese
Vincent – Boxwave capacitative stylus

Listener Pick of the Week

Neva – 10+1 top science apps
Ricardo – Where’s the outrage?

Send your virology questions and comments to [email protected].

TWiV 159: Flu gets the REDD light

ferretHosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.

Click the arrow above to play, or right-click to download TWiV 159 (48 MB .mp3, 80 minutes).

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Links for this episode:

Weekly Science Picks

Rich – Livescribe Smartpen
Alan – Royal Society journal archive
 Vincent – Chronic fatigue syndrome and the CDC by Dave Tuller

Listener Pick of the Week

Judi – Top 7 in Microbiology

Send your virology questions and comments to [email protected].

TWiV 158: Wolverines go viral

poliovirus + CD155Hosts: Vincent Racaniello, Rich Condit, Alice Telesnitsky, and Kathy Spindler

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

Model of poliovirus bound to CD155 made by Stefan Taube.

Click the arrow above to play, or right-click to download TWiV 158 (52 MB .mp3, 87 minutes).

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Links for this episode:

Weekly Science Picks

Alice – Banvard’s Folly by Paul S. Collins
Kathy – The world at seven billion
Rich – The Princess Bride
 Vincent – Center for the history of microbiology

Listener Pick of the Week

Tim – Dead Ends to Somewhere by Richard L. Ward
Don – Ben Goldacre: Battling bad science (TED)

Send your virology questions and comments to [email protected].

TWiV 157: Better innate than never

dendritic cellHosts: Vincent Racaniello, Rich Condit, Alan Dove, Dickson Despommier, Jeremy Luban, and Gabriel Victora

A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.

Photograph of a dendritic cell (green) interacting with T cells (cyan) near a blood vessel by Gabriel Victora.

Click the arrow above to play, or right-click to download TWiV 157 (90 MB .mp3, 125 minutes).

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Links for this episode:

Weekly Science Picks

Dickson – Eats, Shoots & Leaves by Lynne Truss
Rich – Battlestar Galactica
Alan – Coleman LED quad lantern
Gabriel – A History of Immunology by Arthur M. Silverstein
Jeremy – Principles of Virology by Flint, Enquist, Racaniello, Skalka
Vincent – Principles of Molecular Virology by AJ Cann

Listener Pick of the Week

David – Carl Sagan’s Pale Blue Dot (YouTube)

Send your virology questions and comments to [email protected].

TWiV 156: Armed and targeted killer meta-analysis

jx-594Hosts: Vincent Racaniello, Rich Condit, and Dickson Despommier

Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.

Click the arrow above to play, or right-click to download TWiV 156 (57 MB .mp3, 94 minutes).

Subscribe (free): iTunes, RSS, email

Links for this episode:

Weekly Science Picks

Rich – Google’s self-driving car (story one and two)
Dickson – Wild Russia and Wild China TV series
Vincent – Baculovirus molecular biology by George Rohrmann (free)

Listener Pick of the Week

Jim – Lee Cronin: Making matter come alive (TED)

Send your virology questions and comments to [email protected].

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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