Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche
Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses.
Click the arrow above to play, or right-click to download TWiV 191 (71 MB .mp3, 99 minutes).
Subscribe (free): iTunes, RSS, email
Links for this episode:
- Outbreak in Cambodia (CNN)
- Pathogen mix in Cambodian illness (ProMedMail)
- Undiagnosed illness in Cambodia (WHO)
- Enterovirus 71 (virology blog)
- Recombination among attenuated vaccines (Science)
- An outbreak of irony (Ed Yong)
- Infectious laryngotracheitis
- Gallid herpesvirus 1 (Wikipedia)
- Iltovirus (ViralZone)
- TWiV on Facebook
- Letters read on TWiV 191
Weekly Science Picks
Alan – H5N1 genetic changes inventory
Rich – Mythbusters: Diet Coke and Mentos (YouTube channel)
Nissin – The Pox and the Covenant by Tony Williams, and Tereza Batista, Tired of War by Jorge Amado
Vincent – FAQ: The ‘snake bite’ portion of your thesis defense
Listener Pick of the Week
Gopal – All’s not fair in science and publishing
Luis – The Origin of AIDS by Jacques Pepin (Nature review)
Sven – Visualizing information flow in science
Send your virology questions and comments to twiv@microbe.tv.
I’ve been looking at the genome sequences of Enterovirus-71 (EV-71). Plenty of them are available on NCBI, most from Chinese outbreaks. It’s an impressive virus and so many strains are out there, likely makes a vaccine problematic. There is a nice mouse-adapted strain of EV-71 and a few infectious clones reported in the literature. Vincent, you bring up good points about EV-71, it may be more informative to look at the genomes of the host children. Finally, just like H5N1 we only hear about the cases that end up in the emergency room. I hope the press doesn’t start saying the virus kills 80% of the people it infects 🙂
Does anyone have a good reference that gets at the infection control doc’s email concerning the different modes of transmission for different pathogens? I would love to throw some data for some different pathogens at my allied health micro class for them to interpret… I know its out there but it I am stymied every time I search pubmed for something so broad.