Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.
From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.
Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.
Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.
Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.
