Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses.
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more.