ImmuneImmuneImmuneImmune

Tag: immune

  • Immune

Immune 13: Do no harm

  • October 20, 2018
  • Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

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  • Immune

Immune 12: Systems immunology

  • September 19, 2018
  • Tagged as: cell sorting, cord blood, CyTOF, FACS, immune, immune system, immunology, microbiome, newborn children, postnatal immunity, RNAseq, systems immunology

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

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  • Immune

Immune 11: Immunomimetic designer cells

  • August 18, 2018
  • Tagged as: biofilm, gene network, immune, immunology, immunomimetic, implant infection, inflammation, innate immune response, lysostaphin, MRSA, Staphylococcus aureus

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.

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  • Immune

Immune 10: Immune goes viral

  • July 21, 2018
  • Tagged as: antibodies, antibody escape mutants, broadly neutralizing antibodies, HIV-1, immune, immunology, Rebecca Lynch

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

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  • Immune

Immune 9: Neither mice nor lamprey lie

  • June 20, 2018
  • Tagged as: antibodies, hagfish, immune, immunity, immunoglobulins, jawed vertebrates, jawless vertebrates, lamprey, leucine rich repeat, variable lymphocyte receptor, VLR

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

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  • Uncategorized

Immune 8: Staying warm with γδ T cells

  • May 25, 2018
  • Tagged as: homeostasis, IL-17A, immune, immunology, T cells, thermogenesis, γδT cells

The Immune team reveals how γδT cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

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  • Immune

Immune 7: Contradictory complements in Alzheimer’s Disease

  • April 18, 2018
  • Tagged as: AD, Alzheimer's disease, C1q, complement, immune, immunology, MAC, mouse model, synapse, synaptic pruning

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer’s disease.

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  • Immune

Immune 6: Potent antiviral antibodies without somatic mutation

  • March 16, 2018
  • Tagged as: antibody, B cell, epitope, F protein, IgG, IgM, immune, immune response, immunology, lymph node, respiratory syncytial virus, somatic hypermutation, V(D)J recombination, vaccine enhanced disease

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

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  • Immune

Immune 5: Mother knows best about food allergies

  • February 22, 2018
  • Tagged as: allergic reactions, atopy, breast milk, food allergy, immune, immunology, mucosal defenses, mucosal immunology, tolerance

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.

3 Replies
  • Immune

Immune 4: Putting the immunotherapy CAR T before the cancer

  • January 23, 2018
  • Tagged as: B cell, cancer immunotherapy, CAR T cell, checkpoint inhibitor, chimeric antigen receptor, CTLA4, immune, immunology, immunotherapy, oncology, PD-1, T cell, Tisagenlecleucel

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.

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