Immune 53: Dendritic cell robbers

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune 52: B cell boot camp with Gabriel Victora

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Gabriel Victora

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 51: Teenage NINJA mice with Nikhil Joshi

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Nikhil Joshi

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  • Creation of NINJA mice (Nature Biotech) 10:00
  • Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 50: Red blood cells are immune sentinels

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 49: I fell in love with worms with Keke Fairfax

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Keke Fairfax

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 48: Environmental enteric dysfunction with Timothy Hand

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Timothy Hand

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 47: Trapping viruses in NETs

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 46: Bats don’t STING like a bee

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 45: Immune messages

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 45 (50 MB .mp3, 84 min)
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Links for this episode

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune 44: Got IgA on the brain

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Download Immune 44 (47 MB .mp3, 79 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

The Hosts of IMMUNE

Brianne Barker, Ph.D.


Stephanie Langel, Ph.D.


Cindy Leifer, Ph.D.


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