Immune - Part 9

Immune

Immune 21: Islets of Langelhans

June 12, 2019
Tagged as: autoimmunity, B cells, BCR, dual expressing lymphocytes, immune, immunology, public BCR, T cells, TCR, type I diabetes

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Dual receptor lymphocytes and type I diabetes (Cell) 29:47
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:18:43

Steph – Unique Scientists
Cindy – Researcher app
Vincent – STLR Conversations Podcast

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 20: In defense of death

May 29, 2019
Tagged as: blood clotting, gasdermin, immune, immunology, inflammasome, inflammation, pyroptosis, thrombosis, tissue factor

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Inflammasome activation triggers blood clotting (Immunity) 4:06
Rotavirus and Nlrp9b inflammasome (Nature) 53:55
Societal Amnesia and vaccines by Cindy Leifer 1:20:22
Image credit
Letters read on Immune 20 58:01
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:13:56

Steph – iBiology Immunology Course
Cindy – Changing vaccine hesitancy
Vincent – Bad Advice by Paul Offit (and Vaccines and Your Child)

Listener Pick

Steve – An Elegant Defense

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 19: Mom’s the word

April 17, 2019
Tagged as: antibody, herpes simplex virus, immune, immunology, neonatal herpes, neurotropic, placental antibody transfer, vaccination, vaccine, virus

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Maternal immunization protects offspring (Sci Trans Med) 5:42
Diversity of herpesvirus in neonates (TWiV 540) 4:48
Mariana Mazzucato on Freakonomics 1:05:09
Letters read on Immune 19 57:02
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:10:05

Steph – iNaturalist
Cindy – Taking a break is also hard work
Vincent – Immunology Wall Posters

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 18: Biting off more TCR than you can chew

March 27, 2019
Tagged as: immune, immunology, MHC I, MHC II, peptide, T cell receptor, trogocytosis

The immunophiles discuss T cell antigen discovery by trogocytosis – the transfer of membrane patches among cells in close contact.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Trogocytosis for T cell antigen discovery (Nat Methods) 25:02
Trogocytosis (J Immunol)
Orphan T cell receptors (Cell)
Trogocytosis video (YouTube) 17:21
Image credit
Letters read on Immune 18 1:01:50
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:07:15

Steph – Scientists rise up against statistical significance
Cindy – Why I quit my PhD and returned
Vincent – The Law and Vaccine Resistance

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune

Immune 17: Feed a macrophage, starve a tumor

February 13, 2019
Tagged as: cancer, CD47, CpG, glycolysis, immune, immunology, Krebs cycle, Tlr9, tumor

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Darwin Day 1:17
Metabolic rewiring of macrophages by CpG (Nat Immunol) 2:27, 26:39
Letters read on Immune 17 52:52
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:01:30

Steph – Pregnant Scholar
Cindy – Anti-vaxxers vaccinating against measles
Vincent – Center for Science in the Public Interest

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 16: B is for Bursa

January 19, 2019
Tagged as: B cells, Bursa, gene knockout, herpesvirus, immune, immunology, Marek's disease, pathogenesis

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek’s disease herpesvirus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Role of B cells in Marek’s disease pathogenesis (PNAS) 5:09
In ovo vaccination (YouTube) 11:47
First chickens lacking B cells (PNAS) 19:00
Letters read on Immune 16 45:30
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:01:20

Steph – 7 Days Out
Cindy – Watson PBS documentary and Cold Spring Harbor Laboratory response
Vincent – Dads can donate mitochondrial DNA and Chicken puns

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 15: Happy neu-trophil year

December 22, 2018
Tagged as: diapedesis, immune, immunology, leukocyte, neutrophil, neutrophil net, neutrophil rolling, tether and sling

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Slings enable neutrophil rolling (Nature) 33:20
Sling video (La Jolla Inst Allergy Immunol) 32:43
Neutrophil extracellular traps kill bacteria (Science) 50:45
Neutrophil review (Sci Immunol)
Image credit
Letters read on Immune 15 1:04:06
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:14:01

Steph – Should reviewers remain anonymous?
Cindy – Breast Cancer Research Foundation
Vincent – Initiative to End Paywalls (The Scientist)

Listener Pick

Jim – Eat to Live (YouTube)

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 14: Braking bad

November 14, 2018
Tagged as: cancer immunotherapy, CTLA-4, immune, immune checkpoint inhibitor, immunology, immunotherapy, James Allison Tasuku Honjo, Nobel Prize, PD-1, PDL-1, T cell

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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2018 Nobel Prize in Medicine 5:53
2018 Nobel Prize in Medicine (pdf)
What’s in a name? (Can Res Inst) 38:19
Checkpoint inhibitor failures (Nature) 1:03:06
Image credit
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:13:25

Steph – Immunobites
Cindy – List of immunology Nobels
Vincent – Prof. Barker’s Immunology lectures

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 13: Do no harm

October 20, 2018
Tagged as: IFN, immune, immunology, innate immunity, innate sensor, interferon, lncRNA, long noncoding RNA, RIG-I, toll-like receptor

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Host lncRNA binds RIG-I (Cell) 18:16
Microbe Art at virology blog 1:09:40
Letters read on Immune 13 50:59
Time stamps by Jolene. Thanks!

Weekly Science Picks 1:07:18

Steph – That’s Pediatrics Podcast
Cindy – Trilobite Glassworks
Vincent – Research!America

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Immune

Immune 12: Systems immunology

September 19, 2018
Tagged as: cell sorting, cord blood, CyTOF, FACS, immune, immune system, immunology, microbiome, newborn children, postnatal immunity, RNAseq, systems immunology

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Immune system development in newborns (Cell) 25:15
Dead parrots and live wildcats (TWiV 185) 1:00:35
Pathogenesis card game (JAMA) 1:04:06
Letters read on Immune 12 55:33

Weekly Science Picks 1:04:07

Steph – Kaleidoscopean
Cindy – 500 women scientists
Vincent – NIH budget increase 2019

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

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Immune 21: Islets of Langelhans

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Weekly Science Picks 1:18:43

Immune 20: In defense of death

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Weekly Science Picks 1:13:56

Listener Pick

Immune 19: Mom’s the word

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Weekly Science Picks 1:10:05

Immune 18: Biting off more TCR than you can chew

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Weekly Science Picks 1:07:15

Immune 17: Feed a macrophage, starve a tumor

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Weekly Science Picks 1:01:30

Immune 16: B is for Bursa

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Weekly Science Picks 1:01:20

Immune 15: Happy neu-trophil year

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Weekly Science Picks 1:14:01

Listener Pick

Immune 14: Braking bad

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Weekly Science Picks 1:13:25

Immune 13: Do no harm

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Weekly Science Picks 1:07:18

Immune 12: Systems immunology

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Weekly Science Picks 1:04:07

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