TWiV 847: On Dasher, on Dancer, on Corona and Lassa

For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:27:39

Dickson – EO Wilson (Ants and The Conversation)
Brianne – The Best Fun Science Stories of 2021
Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story
Alan – Owls of the Easern Ice, by Jonathan Slaght
Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars

Listener Picks

Larry – Immunity
Jeff – Daily Hospital Surveillance Report

Intro music is by Ronald Jenkees

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TWiV 848: COVID-19 clinical update #95 with Dr. Daniel Griffin

In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor’s COVID vaccine, and COVID-OUT for ivermectin.

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Intro music is by Ronald Jenkees

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TWiV 846: Beta was stirring, and now in a mouse

TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:21:08

Brianne – XKCD on Immune Responses and Immunity
Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore
Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment
Alan – Sokobond puzzle game
Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts

Intro music is by Ronald Jenkees

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TWiV 845: COVID-19 clinical update #94 with Dr. Daniel Griffin

In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients.

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Intro music is by Ronald Jenkees

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TWiV 844: Paul Offit on children, COVID, and boosters

Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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Weekly Picks 1:28:48

Brianne – Virus snowflakes
Dickson – The Year in Pictures 2021
Vincent – Our Life is Plasticized

Listener Picks

Gerry – Dan Barouch: COVID-19 Vaccine Development
Louise – Pandora’s Lab by Paul Offit

Intro music is by Ronald Jenkees

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TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin

In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV 842: The clot thickens

TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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Weekly Picks 58:41

Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year
Kathy – Snake dietary diversity
Vincent – Alfred Wegener Institute on Instagram

Listener Picks

Niclas – Once upon a time… Life

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 841: Unmasking immunity

TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Weekly Picks 1:22:29

Dickson – Cities at Night
Amy – I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds
Rich – International Dark Sky Association
Vincent – SARS-CoV-2 variants

Listener Picks

Keith – Ventusky

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin

In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 839: The long and the short of it: get vaccinated

TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:24:27

Kathy – CDC U-M flu report (lay version, MMWR)
Rich – Thagomizer
Alan – Descent into Darkness by Edward Raymer
Vincent – Funding: Blinding peer review

Listener Picks

Lynne – ACE2 in chewing gum

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Rich Condit, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


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