TWiV 740: Complementation will get you everywhere

April 8, 2021

The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:20:38

DicksonLet us now praise tiny ants
BrianneSmall-school science
RichSmallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
KathyThe Transcontinental Burrito Tunnel
VincentGlass music by Robert Tiso

Intro music is by Ronald Jenkees

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2 comments on “TWiV 740: Complementation will get you everywhere

  1. Walker Apr 9, 2021

    Hi,
    nice podcast! Did you know what’s going on beside, the handling of Covid-19? For example in Germany, where Drosten was artifically made a big player? Where his Test creates huge false positve results, where death certificats (accident, cancer, heart attact…) are rewritten to Corona? Where influenca cases are relabeld to Corona?
    It is the same Business Project like 2009 with the Swine Flu.

    Greetings out of the Lockdown-Area,
    where no one in quantity is sick as written,
    Dr. Walker

  2. Janet Apr 9, 2021

    It is an experiment, just really badly planned.
    The paper from the Norwegians, including cases:
    https://www.nejm.org/doi/full/10.1056/NEJMoa2104882
    On VIPIT/VITT
    The references 9,10 would seem to point to a loss of tolerance triggered by the immune stimulation (very effective by vaccine- after all somuch work went into guaranteeing this). Candidate antibodies widely present but regulated as norm.
    Obviously continuing to gather data through continued vaccination of the more susceptible will clarify true risk/benefit eventually- so UK data, not EU, Phillipines, South Korea etc. Data on effectiveness of diagnostic/treatment protocol need to be published too. Also making the experiment official by recruiting people actively for pre- and post- vaccination blood sampling would be a good idea?
    I guess this is a sort of vaccine nationalism/heroism.
    A vaccine is not like a drug, which you can stop taking and the effects are better known, idem remedies for these effects. Less flippancy please, the extent of the pathology, beyond these acute presentations, is also as yet undefined. Probably not a worry to you in the US, where from the vantage-point of the Pfizer/Moderna vaccinee, generic prevention of vaccine hesitancy is seen as more of a priority.