The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
TWiV 371: Sympathy for the devil
- January 10, 2016
- Tagged as: attenuation, circulating vaccine-derived poliovirus, eradication, inactivated poliovaccine, IPV, microsatellite DNA, neurovirulence, OPV, oral poliovaccine, poliovirus, reversion, Tasmanian devil, Tasmanian devil facial tumor, transmissible cancer, vaccine seed strain, viral, virology, virus, viruses
The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.